Continuous hepatic arterial infusion chemotherapy for liver metastasis from biliary tract and pancreatic cancers

Yutaro Kato, Akira Tsuyuki, Kiyoshi Kikuchi, Jo Tokuyama, Naoto Kurihara, Yusuke Kumamoto, Yasuo Fujishiro, Hirotoshi Ebinuma

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4 Citations (Scopus)

Abstract

Background: The efficacy of intrahepatic arterial chemotherapy for liver metastasis from biliary tract or pancreatic cancer remains uncertain. Patients and Methods: Five patients with bilio-pancreatic liver metastasis underwent continuous hepatic arterial infusion chemotherapy. One treatment course basically consisted of a 14-day infusion period during which continuous infusions of 5-fluorouracil and intermittent bolus injections of cisplatin were given, and a subsequent 14-day intermission. After two consecutive courses, these drugs were administered bi-weekly. Results: One complete and three partial responses were observed (response rate, 80%). In responders, the responses persisted until or even after the cessation of chemotherapy. The median survival was 15 months after the start of chemotherapy. The longest survivor has been disease-free for 46 months since a liver tumour remaining despite chemotherapy was eradicated by further treatment. Toxicity was acceptable. Conclusion: 5-Fluorouracil and cisplatin-based continuous hepatic arterial infusion chemotherapy may serve as a promising treatment for bilio-pancreatic liver metastasis.

Original languageEnglish
Pages (from-to)477-482
Number of pages6
JournalAnticancer research
Volume25
Issue number1 B
Publication statusPublished - 01-01-2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Kato, Y., Tsuyuki, A., Kikuchi, K., Tokuyama, J., Kurihara, N., Kumamoto, Y., Fujishiro, Y., & Ebinuma, H. (2005). Continuous hepatic arterial infusion chemotherapy for liver metastasis from biliary tract and pancreatic cancers. Anticancer research, 25(1 B), 477-482.