Continuous hepatic arterial infusion chemotherapy for liver metastasis from biliary tract and pancreatic cancers

Yutaro Kato, Akira Tsuyuki, Kiyoshi Kikuchi, Jo Tokuyama, Naoto Kurihara, Yusuke Kumamoto, Yasuo Fujishiro, Hirotoshi Ebinuma

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Background: The efficacy of intrahepatic arterial chemotherapy for liver metastasis from biliary tract or pancreatic cancer remains uncertain. Patients and Methods: Five patients with bilio-pancreatic liver metastasis underwent continuous hepatic arterial infusion chemotherapy. One treatment course basically consisted of a 14-day infusion period during which continuous infusions of 5-fluorouracil and intermittent bolus injections of cisplatin were given, and a subsequent 14-day intermission. After two consecutive courses, these drugs were administered bi-weekly. Results: One complete and three partial responses were observed (response rate, 80%). In responders, the responses persisted until or even after the cessation of chemotherapy. The median survival was 15 months after the start of chemotherapy. The longest survivor has been disease-free for 46 months since a liver tumour remaining despite chemotherapy was eradicated by further treatment. Toxicity was acceptable. Conclusion: 5-Fluorouracil and cisplatin-based continuous hepatic arterial infusion chemotherapy may serve as a promising treatment for bilio-pancreatic liver metastasis.

Original languageEnglish
Pages (from-to)477-482
Number of pages6
JournalAnticancer research
Issue number1 B
Publication statusPublished - 01-2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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