Continuous infusion of β-amyloid protein into the rat cerebral ventricle induces learning impairment and neuronal and morphological degeneration

Atsumi Nitta, Taneo Fukuta, Takaaki Hasegawa, Toshitaka Nabeshima

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Abstract

To investigate the toxicity of β-amyloid protein, a component of the senile plaques in Alzheimer's disease, it was infused into the cerebral ventricle of rats for 14 days by a mini-osmotic pump. Performances in the water maze and passive avoidance tasks in β-amyloid protein-treated rats were impaired. Choline acetyltransferase activity significantly decreased in the hippocampus both immediately and 2 weeks after the cessation of the infusion. However, the learning impairment was recoverable 2 weeks after cessation of the infusion. Both immediately and 2 weeks after the cessation of the infusion, glial fibrillary acidic protein immunoreactivity increased. Furthermore, β-amyloid protein altered the staining in the nuclei of hippocampal cells for only 2 weeks after the cessation. These results suggest that β-amyloid protein produces some damage in the central nervous system in vivo.

Original languageEnglish
Pages (from-to)51-57
Number of pages7
JournalJapanese Journal of Pharmacology
Volume73
Issue number1
DOIs
Publication statusPublished - 01-01-1997

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All Science Journal Classification (ASJC) codes

  • Pharmacology

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