Contrast-enhanced endoscopic ultrasonography in digestive diseases

Yoshiki Hirooka, Akihiro Itoh, Hiroki Kawashima, Eizaburo Ohno, Yuya Itoh, Yosuke Nakamura, Takeshi Hiramatsu, Hiroyuki Sugimoto, Hajime Sumi, Daijiro Hayashi, Naoki Omiya, Ryoji Miyahara, Masanao Nakamura, Kohei Funasaka, Masatoshi Ishigami, Yoshiaki Katano, Hidemi Goto

Research output: Contribution to journalReview article

33 Citations (Scopus)

Abstract

Contrast-enhanced endoscopic ultrasonography (CE-EUS) was introduced in the early 1990s. The concept of the injection of carbon dioxide microbubbles into the hepatic artery as a contrast material (enhanced ultrasonography) led to endoscopic ultrasonographic angiography. After the arrival of the first-generation contrast agent, high-frequency (12 MHz) EUS brought about the enhancement of EUS images in the diagnosis of pancreatico-biliary diseases, upper gastrointestinal (GI) cancer, and submucosal tumors. The electronic scanning endosonoscope with both radial and linear probes enabled the use of high-end ultrasound machines and depicted the enhancement of both color/power Doppler flow-based imaging and harmonic-based imaging using second-generation contrast agents. Many reports have described the usefulness of the differential diagnosis of pancreatic diseases and other abdominal lesions. Quantitative evaluation of CE-EUS images was an objective method of diagnosis using the time-intensity curve (TIC), but it was limited to the region of interest. Recently developed Inflow Time Mapping™ can be generated from stored clips and used to display the pattern of signal enhancement with time after injection, offering temporal difference of contrast agents and improved tumor characterization. On the other hand, three-dimensional CE-EUS images added new information to the literature, but lacked positional information. Three-dimensional CE-EUS with accurate positional information is awaited. To date, most reports have been related to pancreatic lesions or lymph nodes. Hemodynamic analysis might be of use for diseases in other organs: upper GI cancer diagnosis, submucosal tumors, and biliary disorders, and it might also provide functional information. Studies of CE-EUS in diseases in many other organs will increase in the near future.

Original languageEnglish
Pages (from-to)1063-1072
Number of pages10
JournalJournal of Gastroenterology
Volume47
Issue number10
DOIs
Publication statusPublished - 01-10-2012
Externally publishedYes

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Endosonography
Contrast Media
Gastrointestinal Neoplasms
Image Enhancement
Microbubbles
Neoplasms
Pancreatic Diseases
Injections
Hepatic Artery
Surgical Instruments
Carbon Dioxide
Ultrasonography
Angiography
Differential Diagnosis
Color
Lymph Nodes
Hemodynamics

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Hirooka, Y., Itoh, A., Kawashima, H., Ohno, E., Itoh, Y., Nakamura, Y., ... Goto, H. (2012). Contrast-enhanced endoscopic ultrasonography in digestive diseases. Journal of Gastroenterology, 47(10), 1063-1072. https://doi.org/10.1007/s00535-012-0662-4
Hirooka, Yoshiki ; Itoh, Akihiro ; Kawashima, Hiroki ; Ohno, Eizaburo ; Itoh, Yuya ; Nakamura, Yosuke ; Hiramatsu, Takeshi ; Sugimoto, Hiroyuki ; Sumi, Hajime ; Hayashi, Daijiro ; Omiya, Naoki ; Miyahara, Ryoji ; Nakamura, Masanao ; Funasaka, Kohei ; Ishigami, Masatoshi ; Katano, Yoshiaki ; Goto, Hidemi. / Contrast-enhanced endoscopic ultrasonography in digestive diseases. In: Journal of Gastroenterology. 2012 ; Vol. 47, No. 10. pp. 1063-1072.
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Hirooka, Y, Itoh, A, Kawashima, H, Ohno, E, Itoh, Y, Nakamura, Y, Hiramatsu, T, Sugimoto, H, Sumi, H, Hayashi, D, Omiya, N, Miyahara, R, Nakamura, M, Funasaka, K, Ishigami, M, Katano, Y & Goto, H 2012, 'Contrast-enhanced endoscopic ultrasonography in digestive diseases', Journal of Gastroenterology, vol. 47, no. 10, pp. 1063-1072. https://doi.org/10.1007/s00535-012-0662-4

Contrast-enhanced endoscopic ultrasonography in digestive diseases. / Hirooka, Yoshiki; Itoh, Akihiro; Kawashima, Hiroki; Ohno, Eizaburo; Itoh, Yuya; Nakamura, Yosuke; Hiramatsu, Takeshi; Sugimoto, Hiroyuki; Sumi, Hajime; Hayashi, Daijiro; Omiya, Naoki; Miyahara, Ryoji; Nakamura, Masanao; Funasaka, Kohei; Ishigami, Masatoshi; Katano, Yoshiaki; Goto, Hidemi.

In: Journal of Gastroenterology, Vol. 47, No. 10, 01.10.2012, p. 1063-1072.

Research output: Contribution to journalReview article

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T1 - Contrast-enhanced endoscopic ultrasonography in digestive diseases

AU - Hirooka, Yoshiki

AU - Itoh, Akihiro

AU - Kawashima, Hiroki

AU - Ohno, Eizaburo

AU - Itoh, Yuya

AU - Nakamura, Yosuke

AU - Hiramatsu, Takeshi

AU - Sugimoto, Hiroyuki

AU - Sumi, Hajime

AU - Hayashi, Daijiro

AU - Omiya, Naoki

AU - Miyahara, Ryoji

AU - Nakamura, Masanao

AU - Funasaka, Kohei

AU - Ishigami, Masatoshi

AU - Katano, Yoshiaki

AU - Goto, Hidemi

PY - 2012/10/1

Y1 - 2012/10/1

N2 - Contrast-enhanced endoscopic ultrasonography (CE-EUS) was introduced in the early 1990s. The concept of the injection of carbon dioxide microbubbles into the hepatic artery as a contrast material (enhanced ultrasonography) led to endoscopic ultrasonographic angiography. After the arrival of the first-generation contrast agent, high-frequency (12 MHz) EUS brought about the enhancement of EUS images in the diagnosis of pancreatico-biliary diseases, upper gastrointestinal (GI) cancer, and submucosal tumors. The electronic scanning endosonoscope with both radial and linear probes enabled the use of high-end ultrasound machines and depicted the enhancement of both color/power Doppler flow-based imaging and harmonic-based imaging using second-generation contrast agents. Many reports have described the usefulness of the differential diagnosis of pancreatic diseases and other abdominal lesions. Quantitative evaluation of CE-EUS images was an objective method of diagnosis using the time-intensity curve (TIC), but it was limited to the region of interest. Recently developed Inflow Time Mapping™ can be generated from stored clips and used to display the pattern of signal enhancement with time after injection, offering temporal difference of contrast agents and improved tumor characterization. On the other hand, three-dimensional CE-EUS images added new information to the literature, but lacked positional information. Three-dimensional CE-EUS with accurate positional information is awaited. To date, most reports have been related to pancreatic lesions or lymph nodes. Hemodynamic analysis might be of use for diseases in other organs: upper GI cancer diagnosis, submucosal tumors, and biliary disorders, and it might also provide functional information. Studies of CE-EUS in diseases in many other organs will increase in the near future.

AB - Contrast-enhanced endoscopic ultrasonography (CE-EUS) was introduced in the early 1990s. The concept of the injection of carbon dioxide microbubbles into the hepatic artery as a contrast material (enhanced ultrasonography) led to endoscopic ultrasonographic angiography. After the arrival of the first-generation contrast agent, high-frequency (12 MHz) EUS brought about the enhancement of EUS images in the diagnosis of pancreatico-biliary diseases, upper gastrointestinal (GI) cancer, and submucosal tumors. The electronic scanning endosonoscope with both radial and linear probes enabled the use of high-end ultrasound machines and depicted the enhancement of both color/power Doppler flow-based imaging and harmonic-based imaging using second-generation contrast agents. Many reports have described the usefulness of the differential diagnosis of pancreatic diseases and other abdominal lesions. Quantitative evaluation of CE-EUS images was an objective method of diagnosis using the time-intensity curve (TIC), but it was limited to the region of interest. Recently developed Inflow Time Mapping™ can be generated from stored clips and used to display the pattern of signal enhancement with time after injection, offering temporal difference of contrast agents and improved tumor characterization. On the other hand, three-dimensional CE-EUS images added new information to the literature, but lacked positional information. Three-dimensional CE-EUS with accurate positional information is awaited. To date, most reports have been related to pancreatic lesions or lymph nodes. Hemodynamic analysis might be of use for diseases in other organs: upper GI cancer diagnosis, submucosal tumors, and biliary disorders, and it might also provide functional information. Studies of CE-EUS in diseases in many other organs will increase in the near future.

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Hirooka Y, Itoh A, Kawashima H, Ohno E, Itoh Y, Nakamura Y et al. Contrast-enhanced endoscopic ultrasonography in digestive diseases. Journal of Gastroenterology. 2012 Oct 1;47(10):1063-1072. https://doi.org/10.1007/s00535-012-0662-4