Contribution of different opioid systems to footshock-induced analgesia and motor suppression

Toshitaka Nabeshima, Kiyofumi Yamada, Tsutomu Kameyama

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Mice, subjected to footschock, showed a significant increase of pain threshold and motor suppression immediately after the footshock and both effects magnitude of footshock-induced analgesia, but not motor suppression, was significantly less in morphine-tolerant mice than in non-tolerant mice. On the other hand, the magnitude of motor suppression, but not analgesia, was significantly less in ethylketocyclazocine- and pentazocine-tolerant mice than in non-tolerant mice. Furthermore, the apparent development of tolerance to both phenomena by successive daily footshocks was strikingly different. Tolerance to footshock-induced analgesia was induced on day 4 by the successive footshocks, while tolerance to motor suppresion was not observed until day 17 of successive daily footshocks. In addition, the antinociceptive effect of morphine was significantly attenuated in mice tolerant to footshock-induced analgesia. These results suggest that different opioid systems may participate in footshock-induced analgesia and motor suppression. In addition, it is suggested that footshock-induced analgesia may be mediated by μ and/or δ receptors and motor suppression may be mediated by κ and/or δ receptors.

Original languageEnglish
Pages (from-to)199-205
Number of pages7
JournalEuropean Journal of Pharmacology
Volume92
Issue number3-4
DOIs
Publication statusPublished - 02-09-1983
Externally publishedYes

Fingerprint

Analgesia
Opioid Analgesics
Morphine
Ethylketocyclazocine
Pentazocine
Pain Threshold

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

@article{5b2936c4a7aa4eb68213da9f29cba226,
title = "Contribution of different opioid systems to footshock-induced analgesia and motor suppression",
abstract = "Mice, subjected to footschock, showed a significant increase of pain threshold and motor suppression immediately after the footshock and both effects magnitude of footshock-induced analgesia, but not motor suppression, was significantly less in morphine-tolerant mice than in non-tolerant mice. On the other hand, the magnitude of motor suppression, but not analgesia, was significantly less in ethylketocyclazocine- and pentazocine-tolerant mice than in non-tolerant mice. Furthermore, the apparent development of tolerance to both phenomena by successive daily footshocks was strikingly different. Tolerance to footshock-induced analgesia was induced on day 4 by the successive footshocks, while tolerance to motor suppresion was not observed until day 17 of successive daily footshocks. In addition, the antinociceptive effect of morphine was significantly attenuated in mice tolerant to footshock-induced analgesia. These results suggest that different opioid systems may participate in footshock-induced analgesia and motor suppression. In addition, it is suggested that footshock-induced analgesia may be mediated by μ and/or δ receptors and motor suppression may be mediated by κ and/or δ receptors.",
author = "Toshitaka Nabeshima and Kiyofumi Yamada and Tsutomu Kameyama",
year = "1983",
month = "9",
day = "2",
doi = "10.1016/0014-2999(83)90287-X",
language = "English",
volume = "92",
pages = "199--205",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
publisher = "Elsevier",
number = "3-4",

}

Contribution of different opioid systems to footshock-induced analgesia and motor suppression. / Nabeshima, Toshitaka; Yamada, Kiyofumi; Kameyama, Tsutomu.

In: European Journal of Pharmacology, Vol. 92, No. 3-4, 02.09.1983, p. 199-205.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Contribution of different opioid systems to footshock-induced analgesia and motor suppression

AU - Nabeshima, Toshitaka

AU - Yamada, Kiyofumi

AU - Kameyama, Tsutomu

PY - 1983/9/2

Y1 - 1983/9/2

N2 - Mice, subjected to footschock, showed a significant increase of pain threshold and motor suppression immediately after the footshock and both effects magnitude of footshock-induced analgesia, but not motor suppression, was significantly less in morphine-tolerant mice than in non-tolerant mice. On the other hand, the magnitude of motor suppression, but not analgesia, was significantly less in ethylketocyclazocine- and pentazocine-tolerant mice than in non-tolerant mice. Furthermore, the apparent development of tolerance to both phenomena by successive daily footshocks was strikingly different. Tolerance to footshock-induced analgesia was induced on day 4 by the successive footshocks, while tolerance to motor suppresion was not observed until day 17 of successive daily footshocks. In addition, the antinociceptive effect of morphine was significantly attenuated in mice tolerant to footshock-induced analgesia. These results suggest that different opioid systems may participate in footshock-induced analgesia and motor suppression. In addition, it is suggested that footshock-induced analgesia may be mediated by μ and/or δ receptors and motor suppression may be mediated by κ and/or δ receptors.

AB - Mice, subjected to footschock, showed a significant increase of pain threshold and motor suppression immediately after the footshock and both effects magnitude of footshock-induced analgesia, but not motor suppression, was significantly less in morphine-tolerant mice than in non-tolerant mice. On the other hand, the magnitude of motor suppression, but not analgesia, was significantly less in ethylketocyclazocine- and pentazocine-tolerant mice than in non-tolerant mice. Furthermore, the apparent development of tolerance to both phenomena by successive daily footshocks was strikingly different. Tolerance to footshock-induced analgesia was induced on day 4 by the successive footshocks, while tolerance to motor suppresion was not observed until day 17 of successive daily footshocks. In addition, the antinociceptive effect of morphine was significantly attenuated in mice tolerant to footshock-induced analgesia. These results suggest that different opioid systems may participate in footshock-induced analgesia and motor suppression. In addition, it is suggested that footshock-induced analgesia may be mediated by μ and/or δ receptors and motor suppression may be mediated by κ and/or δ receptors.

UR - http://www.scopus.com/inward/record.url?scp=0020636394&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020636394&partnerID=8YFLogxK

U2 - 10.1016/0014-2999(83)90287-X

DO - 10.1016/0014-2999(83)90287-X

M3 - Article

C2 - 6138260

AN - SCOPUS:0020636394

VL - 92

SP - 199

EP - 205

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 3-4

ER -