Controlling Firing Point of Microfiber-Shaped Hipsc-Derived Cardiac Tissue with Localized Electrical Stimulation Device

Akari Masuda; Shun Itai; Yuta Kurashina; Shugo Tohyama; Hiroaki Onoe

doi:10.1109/MEMS49605.2023.10052536

Controlling Firing Point of Microfiber-Shaped Hipsc-Derived Cardiac Tissue with Localized Electrical Stimulation Device

Akari Masuda, Shun Itai, Yuta Kurashina, Shugo Tohyama, Hiroaki Onoe

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We propose a device to apply localized electrical stimulation to control cardiac conduction in in vitro cardiac tissue. Our system can initiate the generation of electrical impulses at any location by applying local electrical stimulation to the desired point of the microfiber-shaped cardiac tissue. Our system generated a strong and intense electric field between the electrodes in FEM analysis, indicating only the cardiac tissue between the electrodes was electrically stimulated. We could observe the cardiac conduction optically by visualizing the timing and location of impulses with calcium imaging at any location and time on the tissue. The system enables accurate analysis of cardiac potential and conduction velocity of the heart model, and could contribute to the elucidation of pathological dynamics such as arrhythmia, whose mechanism of occurrence still remains unknown.

Original language	English
Title of host publication	2023 IEEE 36th International Conference on Micro Electro Mechanical Systems, MEMS 2023
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	305-308
Number of pages	4
ISBN (Electronic)	9781665493086
DOIs	https://doi.org/10.1109/MEMS49605.2023.10052536
Publication status	Published - 2023
Externally published	Yes
Event	36th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2023 - Munich, Germany Duration: 15-01-2023 → 19-01-2023

Publication series

Name	Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Volume	2023-January
ISSN (Print)	1084-6999

Conference

Conference	36th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2023
Country/Territory	Germany
City	Munich
Period	15-01-23 → 19-01-23

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Mechanical Engineering
Electrical and Electronic Engineering

Access to Document

10.1109/MEMS49605.2023.10052536

Cite this

Masuda, A., Itai, S., Kurashina, Y., Tohyama, S., & Onoe, H. (2023). Controlling Firing Point of Microfiber-Shaped Hipsc-Derived Cardiac Tissue with Localized Electrical Stimulation Device. In 2023 IEEE 36th International Conference on Micro Electro Mechanical Systems, MEMS 2023 (pp. 305-308). (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); Vol. 2023-January). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MEMS49605.2023.10052536

Masuda, Akari ; Itai, Shun ; Kurashina, Yuta et al. / Controlling Firing Point of Microfiber-Shaped Hipsc-Derived Cardiac Tissue with Localized Electrical Stimulation Device. 2023 IEEE 36th International Conference on Micro Electro Mechanical Systems, MEMS 2023. Institute of Electrical and Electronics Engineers Inc., 2023. pp. 305-308 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

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title = "Controlling Firing Point of Microfiber-Shaped Hipsc-Derived Cardiac Tissue with Localized Electrical Stimulation Device",

abstract = "We propose a device to apply localized electrical stimulation to control cardiac conduction in in vitro cardiac tissue. Our system can initiate the generation of electrical impulses at any location by applying local electrical stimulation to the desired point of the microfiber-shaped cardiac tissue. Our system generated a strong and intense electric field between the electrodes in FEM analysis, indicating only the cardiac tissue between the electrodes was electrically stimulated. We could observe the cardiac conduction optically by visualizing the timing and location of impulses with calcium imaging at any location and time on the tissue. The system enables accurate analysis of cardiac potential and conduction velocity of the heart model, and could contribute to the elucidation of pathological dynamics such as arrhythmia, whose mechanism of occurrence still remains unknown.",

author = "Akari Masuda and Shun Itai and Yuta Kurashina and Shugo Tohyama and Hiroaki Onoe",

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language = "English",

series = "Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)",

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Masuda, A, Itai, S, Kurashina, Y, Tohyama, S & Onoe, H 2023, Controlling Firing Point of Microfiber-Shaped Hipsc-Derived Cardiac Tissue with Localized Electrical Stimulation Device. in 2023 IEEE 36th International Conference on Micro Electro Mechanical Systems, MEMS 2023. Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), vol. 2023-January, Institute of Electrical and Electronics Engineers Inc., pp. 305-308, 36th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2023, Munich, Germany, 15-01-23. https://doi.org/10.1109/MEMS49605.2023.10052536

Controlling Firing Point of Microfiber-Shaped Hipsc-Derived Cardiac Tissue with Localized Electrical Stimulation Device. / Masuda, Akari; Itai, Shun; Kurashina, Yuta et al.
2023 IEEE 36th International Conference on Micro Electro Mechanical Systems, MEMS 2023. Institute of Electrical and Electronics Engineers Inc., 2023. p. 305-308 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); Vol. 2023-January).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AB - We propose a device to apply localized electrical stimulation to control cardiac conduction in in vitro cardiac tissue. Our system can initiate the generation of electrical impulses at any location by applying local electrical stimulation to the desired point of the microfiber-shaped cardiac tissue. Our system generated a strong and intense electric field between the electrodes in FEM analysis, indicating only the cardiac tissue between the electrodes was electrically stimulated. We could observe the cardiac conduction optically by visualizing the timing and location of impulses with calcium imaging at any location and time on the tissue. The system enables accurate analysis of cardiac potential and conduction velocity of the heart model, and could contribute to the elucidation of pathological dynamics such as arrhythmia, whose mechanism of occurrence still remains unknown.

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Masuda A, Itai S, Kurashina Y, Tohyama S, Onoe H. Controlling Firing Point of Microfiber-Shaped Hipsc-Derived Cardiac Tissue with Localized Electrical Stimulation Device. In 2023 IEEE 36th International Conference on Micro Electro Mechanical Systems, MEMS 2023. Institute of Electrical and Electronics Engineers Inc. 2023. p. 305-308. (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). doi: 10.1109/MEMS49605.2023.10052536

Controlling Firing Point of Microfiber-Shaped Hipsc-Derived Cardiac Tissue with Localized Electrical Stimulation Device

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