TY - JOUR
T1 - Conventional magnetic resonance imaging key features for distinguishing pathologically confirmed corticobasal degeneration from its mimics
T2 - a retrospective analysis of the J-VAC study
AU - J-VAC study group
AU - Sakurai, Keita
AU - Tokumaru, Aya M.
AU - Yoshida, Mari
AU - Saito, Yuko
AU - Wakabayashi, Koichi
AU - Komori, Takashi
AU - Hasegawa, Masato
AU - Ikeuchi, Takeshi
AU - Hayashi, Yuichi
AU - Shimohata, Takayoshi
AU - Murayama, Shigeo
AU - Iwasaki, Yasushi
AU - Uchihara, Toshiki
AU - Sakai, Motoko
AU - Yabe, Ichiro
AU - Tanikawa, Satoshi
AU - Takigawa, Hiroshi
AU - Adachi, Tadashi
AU - Hanajima, Ritsuko
AU - Fujimura, Harutoshi
AU - Hayashi, Kentaro
AU - Sugaya, Keizo
AU - Hasegawa, Kazuko
AU - Sano, Terunori
AU - Takao, Masaki
AU - Yokota, Osamu
AU - Miki, Tomoko
AU - Kobayashi, Michio
AU - Arai, Nobutaka
AU - Ohkubo, Takuya
AU - Yokota, Takanori
AU - Mori, Keiko
AU - Ito, Masumi
AU - Ishida, Chiho
AU - Idezuka, Jiro
AU - Toyoshima, Yasuko
AU - Kanazawa, Masato
AU - Aoki, Masashi
AU - Hasegawa, Takafumi
AU - Watanabe, Hirohisa
AU - Hashizume, Atsushi
AU - Niwa, Hisayoshi
AU - Yasui, Keizo
AU - Ito, Keita
AU - Washimi, Yukihiko
AU - Kubota, Akatsuki
AU - Toda, Tatsushi
AU - Nakashima, Kenji
AU - Aiba, Ikuko
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/11
Y1 - 2024/11
N2 - Purpose: Due to the indistinguishable clinical features of corticobasal syndrome (CBS), the antemortem differentiation between corticobasal degeneration (CBD) and its mimics remains challenging. However, the utility of conventional magnetic resonance imaging (MRI) for the diagnosis of CBD has not been sufficiently evaluated. This study aimed to investigate the diagnostic performance of conventional MRI findings in differentiating pathologically confirmed CBD from its mimics. Methods: Semiquantitative visual rating scales were employed to assess the degree and distribution of atrophy and asymmetry on conventional T1-weighted and T2-weighted images. Additionally, subcortical white matter hyperintensity (SWMH) on fluid-attenuated inversion recovery images were visually evaluated. Results: In addition to 19 patients with CBD, 16 with CBD mimics (progressive supranuclear palsy (PSP): 9, Alzheimer’s disease (AD): 4, dementia with Lewy bodies (DLB): 1, frontotemporal lobar degeneration with TAR DNA-binding protein of 43 kDa(FTLD-TDP): 1, and globular glial tauopathy (GGT): 1) were investigated. Compared with the CBD group, the PSP-CBS subgroup showed severe midbrain atrophy without SWMH. The non-PSP-CBS subgroup, comprising patients with AD, DLB, FTLD-TDP, and GGT, showed severe temporal atrophy with widespread asymmetry, especially in the temporal lobes. In addition to over half of the patients with CBD, two with FTLD-TDP and GGT showed SWMH, respectively. Conclusion: This study elucidates the distinct structural changes between the CBD and its mimics based on visual rating scales. The evaluation of atrophic distribution and SWMH may serve as imaging biomarkers of conventional MRI for detecting background pathologies.
AB - Purpose: Due to the indistinguishable clinical features of corticobasal syndrome (CBS), the antemortem differentiation between corticobasal degeneration (CBD) and its mimics remains challenging. However, the utility of conventional magnetic resonance imaging (MRI) for the diagnosis of CBD has not been sufficiently evaluated. This study aimed to investigate the diagnostic performance of conventional MRI findings in differentiating pathologically confirmed CBD from its mimics. Methods: Semiquantitative visual rating scales were employed to assess the degree and distribution of atrophy and asymmetry on conventional T1-weighted and T2-weighted images. Additionally, subcortical white matter hyperintensity (SWMH) on fluid-attenuated inversion recovery images were visually evaluated. Results: In addition to 19 patients with CBD, 16 with CBD mimics (progressive supranuclear palsy (PSP): 9, Alzheimer’s disease (AD): 4, dementia with Lewy bodies (DLB): 1, frontotemporal lobar degeneration with TAR DNA-binding protein of 43 kDa(FTLD-TDP): 1, and globular glial tauopathy (GGT): 1) were investigated. Compared with the CBD group, the PSP-CBS subgroup showed severe midbrain atrophy without SWMH. The non-PSP-CBS subgroup, comprising patients with AD, DLB, FTLD-TDP, and GGT, showed severe temporal atrophy with widespread asymmetry, especially in the temporal lobes. In addition to over half of the patients with CBD, two with FTLD-TDP and GGT showed SWMH, respectively. Conclusion: This study elucidates the distinct structural changes between the CBD and its mimics based on visual rating scales. The evaluation of atrophic distribution and SWMH may serve as imaging biomarkers of conventional MRI for detecting background pathologies.
KW - Asymmetry
KW - Corticobasal degeneration
KW - Corticobasal syndrome
KW - Magnetic resonance imaging
KW - Subcortical white matter hyperintensity
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U2 - 10.1007/s00234-024-03432-w
DO - 10.1007/s00234-024-03432-w
M3 - Article
C2 - 39039147
AN - SCOPUS:85199259475
SN - 0028-3940
VL - 66
SP - 1917
EP - 1929
JO - Neuroradiology
JF - Neuroradiology
IS - 11
ER -