Coproduction of 16S rRNA methyltransferase RmtD or RmtG with KPC-2 and CTX-M group extended-spectrum βlactamases in Klebsiella pneumoniae

Maria Fernanda C. Bueno, Gabriela R. Francisco, Jessica A. O'Hara, Doroti De Oliveira Garcia, Yohei Doi

Research output: Contribution to journalArticle

57 Citations (Scopus)


Eight Klebsiella pneumoniae clinical strains with high-level aminoglycoside resistance were collected from eight hospitals in São Paulo State Brazil, in 2010 and 2011. Three of them produced an RmtD group 16S rRNA methyltransferase, RmtD1 or RmtD2. Five strains were found to produce a novel 16S rRNA methyltransferase, designated RmtG, which shared 57 to 58% amino acid identity with RmtD1 and RmtD2. Seven strains coproduced KPC-2 with or without various CTX-M group extended-spectrum βlactamases, while the remaining strain coproduced CTX-M-2.

Original languageEnglish
Pages (from-to)2397-2400
Number of pages4
JournalAntimicrobial agents and chemotherapy
Issue number5
Publication statusPublished - 01-05-2013
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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