TY - JOUR
T1 - Coproduction of KPC-18 and VIM-1 Carbapenemases by Enterobacter cloacae
T2 - Implications for Newer β-Lactam'β-Lactamase Inhibitor Combinations
AU - Thomson, Gina K.
AU - Snyder, James W.
AU - McElheny, Christi L.
AU - Thomson, Kenneth S.
AU - Doi, Yohei
PY - 2016/3
Y1 - 2016/3
N2 - Enterobacter cloacae strain G6809 with reduced susceptibility to carbapenems was identified from a patient in a long-term acute care hospital in Kentucky. G6809 belonged to sequence type (ST) 88 and carried two carbapenemase genes, blaKPC-18 and blaVIM-1. Whole-genome sequencing localized blaKPC-18 to the chromosome and blaVIM-1 to a 58-kb plasmid. The strain was highly resistant to ceftazidime-avibactam. Insidious coproduction of metallo-β-lactamase with KPC-type carbapenemase has implications for the use of next-generation β-lactam'β-lactamase inhibitor combinations.
AB - Enterobacter cloacae strain G6809 with reduced susceptibility to carbapenems was identified from a patient in a long-term acute care hospital in Kentucky. G6809 belonged to sequence type (ST) 88 and carried two carbapenemase genes, blaKPC-18 and blaVIM-1. Whole-genome sequencing localized blaKPC-18 to the chromosome and blaVIM-1 to a 58-kb plasmid. The strain was highly resistant to ceftazidime-avibactam. Insidious coproduction of metallo-β-lactamase with KPC-type carbapenemase has implications for the use of next-generation β-lactam'β-lactamase inhibitor combinations.
UR - http://www.scopus.com/inward/record.url?scp=84959570300&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84959570300&partnerID=8YFLogxK
U2 - 10.1128/JCM.02739-15
DO - 10.1128/JCM.02739-15
M3 - Article
C2 - 26719440
AN - SCOPUS:84959570300
VL - 54
SP - 791
EP - 794
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
SN - 0095-1137
IS - 3
ER -