Coproduction of KPC-18 and VIM-1 Carbapenemases by Enterobacter cloacae: Implications for Newer β-Lactam'β-Lactamase Inhibitor Combinations

Gina K. Thomson, James W. Snyder, Christi L. McElheny, Kenneth S. Thomson, Yohei Doi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Enterobacter cloacae strain G6809 with reduced susceptibility to carbapenems was identified from a patient in a long-term acute care hospital in Kentucky. G6809 belonged to sequence type (ST) 88 and carried two carbapenemase genes, blaKPC-18 and blaVIM-1. Whole-genome sequencing localized blaKPC-18 to the chromosome and blaVIM-1 to a 58-kb plasmid. The strain was highly resistant to ceftazidime-avibactam. Insidious coproduction of metallo-β-lactamase with KPC-type carbapenemase has implications for the use of next-generation β-lactam'β-lactamase inhibitor combinations.

Original languageEnglish
Pages (from-to)791-794
Number of pages4
JournalJournal of clinical microbiology
Volume54
Issue number3
DOIs
Publication statusPublished - 01-03-2016

Fingerprint

Enterobacter cloacae
Lactams
Carbapenems
Chromosomes, Human, Pair 1
Long-Term Care
Plasmids
Genome
Genes
carbapenemase
ceftazidime drug combination avibactam

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)

Cite this

Thomson, Gina K. ; Snyder, James W. ; McElheny, Christi L. ; Thomson, Kenneth S. ; Doi, Yohei. / Coproduction of KPC-18 and VIM-1 Carbapenemases by Enterobacter cloacae : Implications for Newer β-Lactam'β-Lactamase Inhibitor Combinations. In: Journal of clinical microbiology. 2016 ; Vol. 54, No. 3. pp. 791-794.
@article{6bda28c15f994a7b82e6e6ed511ca8b8,
title = "Coproduction of KPC-18 and VIM-1 Carbapenemases by Enterobacter cloacae: Implications for Newer β-Lactam'β-Lactamase Inhibitor Combinations",
abstract = "Enterobacter cloacae strain G6809 with reduced susceptibility to carbapenems was identified from a patient in a long-term acute care hospital in Kentucky. G6809 belonged to sequence type (ST) 88 and carried two carbapenemase genes, blaKPC-18 and blaVIM-1. Whole-genome sequencing localized blaKPC-18 to the chromosome and blaVIM-1 to a 58-kb plasmid. The strain was highly resistant to ceftazidime-avibactam. Insidious coproduction of metallo-β-lactamase with KPC-type carbapenemase has implications for the use of next-generation β-lactam'β-lactamase inhibitor combinations.",
author = "Thomson, {Gina K.} and Snyder, {James W.} and McElheny, {Christi L.} and Thomson, {Kenneth S.} and Yohei Doi",
year = "2016",
month = "3",
day = "1",
doi = "10.1128/JCM.02739-15",
language = "English",
volume = "54",
pages = "791--794",
journal = "Journal of Clinical Microbiology",
issn = "0095-1137",
publisher = "American Society for Microbiology",
number = "3",

}

Coproduction of KPC-18 and VIM-1 Carbapenemases by Enterobacter cloacae : Implications for Newer β-Lactam'β-Lactamase Inhibitor Combinations. / Thomson, Gina K.; Snyder, James W.; McElheny, Christi L.; Thomson, Kenneth S.; Doi, Yohei.

In: Journal of clinical microbiology, Vol. 54, No. 3, 01.03.2016, p. 791-794.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Coproduction of KPC-18 and VIM-1 Carbapenemases by Enterobacter cloacae

T2 - Implications for Newer β-Lactam'β-Lactamase Inhibitor Combinations

AU - Thomson, Gina K.

AU - Snyder, James W.

AU - McElheny, Christi L.

AU - Thomson, Kenneth S.

AU - Doi, Yohei

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Enterobacter cloacae strain G6809 with reduced susceptibility to carbapenems was identified from a patient in a long-term acute care hospital in Kentucky. G6809 belonged to sequence type (ST) 88 and carried two carbapenemase genes, blaKPC-18 and blaVIM-1. Whole-genome sequencing localized blaKPC-18 to the chromosome and blaVIM-1 to a 58-kb plasmid. The strain was highly resistant to ceftazidime-avibactam. Insidious coproduction of metallo-β-lactamase with KPC-type carbapenemase has implications for the use of next-generation β-lactam'β-lactamase inhibitor combinations.

AB - Enterobacter cloacae strain G6809 with reduced susceptibility to carbapenems was identified from a patient in a long-term acute care hospital in Kentucky. G6809 belonged to sequence type (ST) 88 and carried two carbapenemase genes, blaKPC-18 and blaVIM-1. Whole-genome sequencing localized blaKPC-18 to the chromosome and blaVIM-1 to a 58-kb plasmid. The strain was highly resistant to ceftazidime-avibactam. Insidious coproduction of metallo-β-lactamase with KPC-type carbapenemase has implications for the use of next-generation β-lactam'β-lactamase inhibitor combinations.

UR - http://www.scopus.com/inward/record.url?scp=84959570300&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84959570300&partnerID=8YFLogxK

U2 - 10.1128/JCM.02739-15

DO - 10.1128/JCM.02739-15

M3 - Article

C2 - 26719440

AN - SCOPUS:84959570300

VL - 54

SP - 791

EP - 794

JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

SN - 0095-1137

IS - 3

ER -