Abstract
Enterobacter cloacae strain G6809 with reduced susceptibility to carbapenems was identified from a patient in a long-term acute care hospital in Kentucky. G6809 belonged to sequence type (ST) 88 and carried two carbapenemase genes, blaKPC-18 and blaVIM-1. Whole-genome sequencing localized blaKPC-18 to the chromosome and blaVIM-1 to a 58-kb plasmid. The strain was highly resistant to ceftazidime-avibactam. Insidious coproduction of metallo-β-lactamase with KPC-type carbapenemase has implications for the use of next-generation β-lactam'β-lactamase inhibitor combinations.
| Original language | English |
|---|---|
| Pages (from-to) | 791-794 |
| Number of pages | 4 |
| Journal | Journal of clinical microbiology |
| Volume | 54 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 03-2016 |
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All Science Journal Classification (ASJC) codes
- Microbiology (medical)
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Coproduction of KPC-18 and VIM-1 Carbapenemases by Enterobacter cloacae : Implications for Newer β-Lactam'β-Lactamase Inhibitor Combinations. / Thomson, Gina K.; Snyder, James W.; McElheny, Christi L.; Thomson, Kenneth S.; Doi, Yohei.
In: Journal of clinical microbiology, Vol. 54, No. 3, 03.2016, p. 791-794.Research output: Contribution to journal › Article
TY - JOUR
T1 - Coproduction of KPC-18 and VIM-1 Carbapenemases by Enterobacter cloacae
T2 - Implications for Newer β-Lactam'β-Lactamase Inhibitor Combinations
AU - Thomson, Gina K.
AU - Snyder, James W.
AU - McElheny, Christi L.
AU - Thomson, Kenneth S.
AU - Doi, Yohei
PY - 2016/3
Y1 - 2016/3
N2 - Enterobacter cloacae strain G6809 with reduced susceptibility to carbapenems was identified from a patient in a long-term acute care hospital in Kentucky. G6809 belonged to sequence type (ST) 88 and carried two carbapenemase genes, blaKPC-18 and blaVIM-1. Whole-genome sequencing localized blaKPC-18 to the chromosome and blaVIM-1 to a 58-kb plasmid. The strain was highly resistant to ceftazidime-avibactam. Insidious coproduction of metallo-β-lactamase with KPC-type carbapenemase has implications for the use of next-generation β-lactam'β-lactamase inhibitor combinations.
AB - Enterobacter cloacae strain G6809 with reduced susceptibility to carbapenems was identified from a patient in a long-term acute care hospital in Kentucky. G6809 belonged to sequence type (ST) 88 and carried two carbapenemase genes, blaKPC-18 and blaVIM-1. Whole-genome sequencing localized blaKPC-18 to the chromosome and blaVIM-1 to a 58-kb plasmid. The strain was highly resistant to ceftazidime-avibactam. Insidious coproduction of metallo-β-lactamase with KPC-type carbapenemase has implications for the use of next-generation β-lactam'β-lactamase inhibitor combinations.
UR - http://www.scopus.com/inward/record.url?scp=84959570300&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84959570300&partnerID=8YFLogxK
U2 - 10.1128/JCM.02739-15
DO - 10.1128/JCM.02739-15
M3 - Article
C2 - 26719440
AN - SCOPUS:84959570300
VL - 54
SP - 791
EP - 794
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
SN - 0095-1137
IS - 3
ER -