Coproduction of KPC-18 and VIM-1 Carbapenemases by Enterobacter cloacae: Implications for Newer β-Lactam'β-Lactamase Inhibitor Combinations

Gina K. Thomson, James W. Snyder, Christi L. McElheny, Kenneth S. Thomson, Yohei Doi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Enterobacter cloacae strain G6809 with reduced susceptibility to carbapenems was identified from a patient in a long-term acute care hospital in Kentucky. G6809 belonged to sequence type (ST) 88 and carried two carbapenemase genes, blaKPC-18 and blaVIM-1. Whole-genome sequencing localized blaKPC-18 to the chromosome and blaVIM-1 to a 58-kb plasmid. The strain was highly resistant to ceftazidime-avibactam. Insidious coproduction of metallo-β-lactamase with KPC-type carbapenemase has implications for the use of next-generation β-lactam'β-lactamase inhibitor combinations.

Original languageEnglish
Pages (from-to)791-794
Number of pages4
JournalJournal of clinical microbiology
Volume54
Issue number3
DOIs
Publication statusPublished - 03-2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)

Fingerprint Dive into the research topics of 'Coproduction of KPC-18 and VIM-1 Carbapenemases by Enterobacter cloacae: Implications for Newer β-Lactam'β-Lactamase Inhibitor Combinations'. Together they form a unique fingerprint.

  • Cite this