Abstract
Enterobacter cloacae strain G6809 with reduced susceptibility to carbapenems was identified from a patient in a long-term acute care hospital in Kentucky. G6809 belonged to sequence type (ST) 88 and carried two carbapenemase genes, blaKPC-18 and blaVIM-1. Whole-genome sequencing localized blaKPC-18 to the chromosome and blaVIM-1 to a 58-kb plasmid. The strain was highly resistant to ceftazidime-avibactam. Insidious coproduction of metallo-β-lactamase with KPC-type carbapenemase has implications for the use of next-generation β-lactam'β-lactamase inhibitor combinations.
| Original language | English |
|---|---|
| Pages (from-to) | 791-794 |
| Number of pages | 4 |
| Journal | Journal of clinical microbiology |
| Volume | 54 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 03-2016 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Microbiology (medical)
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Thomson, G. K., Snyder, J. W., McElheny, C. L., Thomson, K. S., & Doi, Y. (2016). Coproduction of KPC-18 and VIM-1 Carbapenemases by Enterobacter cloacae: Implications for Newer β-Lactam'β-Lactamase Inhibitor Combinations. Journal of clinical microbiology, 54(3), 791-794. https://doi.org/10.1128/JCM.02739-15