Coproduction of KPC-18 and VIM-1 Carbapenemases by Enterobacter cloacae: Implications for Newer β-Lactam'β-Lactamase Inhibitor Combinations

Gina K. Thomson; James W. Snyder; Christi L. McElheny; Kenneth S. Thomson; Yohei Doi

doi:10.1128/JCM.02739-15

Coproduction of KPC-18 and VIM-1 Carbapenemases by Enterobacter cloacae: Implications for Newer β-Lactam'β-Lactamase Inhibitor Combinations

Gina K. Thomson
, James W. Snyder
, Christi L. McElheny
, Kenneth S. Thomson
, Yohei Doi

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Enterobacter cloacae strain G6809 with reduced susceptibility to carbapenems was identified from a patient in a long-term acute care hospital in Kentucky. G6809 belonged to sequence type (ST) 88 and carried two carbapenemase genes, bla_KPC-18 and bla_VIM-1. Whole-genome sequencing localized bla_KPC-18 to the chromosome and blaVIM-1 to a 58-kb plasmid. The strain was highly resistant to ceftazidime-avibactam. Insidious coproduction of metallo-β-lactamase with KPC-type carbapenemase has implications for the use of next-generation β-lactam'β-lactamase inhibitor combinations.

Original language	English
Pages (from-to)	791-794
Number of pages	4
Journal	Journal of clinical microbiology
Volume	54
Issue number	3
DOIs	https://doi.org/10.1128/JCM.02739-15
Publication status	Published - 03-2016
Externally published	Yes

All Science Journal Classification (ASJC) codes

Microbiology (medical)

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10.1128/JCM.02739-15

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title = "Coproduction of KPC-18 and VIM-1 Carbapenemases by Enterobacter cloacae: Implications for Newer β-Lactam'β-Lactamase Inhibitor Combinations",

abstract = "Enterobacter cloacae strain G6809 with reduced susceptibility to carbapenems was identified from a patient in a long-term acute care hospital in Kentucky. G6809 belonged to sequence type (ST) 88 and carried two carbapenemase genes, blaKPC-18 and blaVIM-1. Whole-genome sequencing localized blaKPC-18 to the chromosome and blaVIM-1 to a 58-kb plasmid. The strain was highly resistant to ceftazidime-avibactam. Insidious coproduction of metallo-β-lactamase with KPC-type carbapenemase has implications for the use of next-generation β-lactam'β-lactamase inhibitor combinations.",

author = "Thomson, \{Gina K.\} and Snyder, \{James W.\} and McElheny, \{Christi L.\} and Thomson, \{Kenneth S.\} and Yohei Doi",

year = "2016",

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language = "English",

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T1 - Coproduction of KPC-18 and VIM-1 Carbapenemases by Enterobacter cloacae

T2 - Implications for Newer β-Lactam'β-Lactamase Inhibitor Combinations

AU - Thomson, Gina K.

AU - Snyder, James W.

AU - McElheny, Christi L.

AU - Thomson, Kenneth S.

AU - Doi, Yohei

PY - 2016/3

Y1 - 2016/3

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AB - Enterobacter cloacae strain G6809 with reduced susceptibility to carbapenems was identified from a patient in a long-term acute care hospital in Kentucky. G6809 belonged to sequence type (ST) 88 and carried two carbapenemase genes, blaKPC-18 and blaVIM-1. Whole-genome sequencing localized blaKPC-18 to the chromosome and blaVIM-1 to a 58-kb plasmid. The strain was highly resistant to ceftazidime-avibactam. Insidious coproduction of metallo-β-lactamase with KPC-type carbapenemase has implications for the use of next-generation β-lactam'β-lactamase inhibitor combinations.

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DO - 10.1128/JCM.02739-15

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Coproduction of KPC-18 and VIM-1 Carbapenemases by Enterobacter cloacae: Implications for Newer β-Lactam'β-Lactamase Inhibitor Combinations

Abstract

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