Copy Number Variation in Schizophrenia in the Japanese Population

Masashi Ikeda, Branko Aleksic, George Kirov, Yoko Kinoshita, Yoshio Yamanouchi, Tsuyoshi Kitajima, Kunihiro Kawashima, Tomo Okochi, Taro Kishi, Irina Zaharieva, Michael J. Owen, Michael C. O'Donovan, Norio Ozaki, Nakao Iwata

Research output: Contribution to journalArticlepeer-review

101 Citations (Scopus)


Background: Copy number variants (CNVs) have been shown to increase the risk to develop schizophrenia. The best supported findings are at 1q21.1, 15q11.2, 15q13.3, and 22q11.2 and deletions at the gene neurexin 1 (NRXN1). Methods: In this study, we used Affymetrix 5.0 arrays to investigate the role of rare CNVs in 575 patients with schizophrenia and 564 control subjects from Japan. Results: There was a nonsignificant trend for excess of rare CNVs in schizophrenia (p = .087); however, we did not confirm the previously implicated association for very large CNVs (>500 kilobase [kb]) in this population. We provide support for three previous findings in schizophrenia, as we identified one deletion in a case at 1q21.1, one deletion within NRXN1, and four duplications in cases and one in a control subject at 16p13.1, a locus first implicated in autism and later in schizophrenia. Conclusions: In this population, we support some of the previous findings in schizophrenia but could not find an increased burden of very large (>500 kb) CNVs, which was proposed recently. However, we provide support for the role of CNVs at 16p13.1, 1q21.1, and NRXN1.

Original languageEnglish
Pages (from-to)283-286
Number of pages4
JournalBiological Psychiatry
Issue number3
Publication statusPublished - 01-02-2010

All Science Journal Classification (ASJC) codes

  • Biological Psychiatry


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