Coronary plaque characteristics in patients with mild chronic kidney disease-analysis by 320-row area detector computed tomography

Hideki Kawai, Masayoshi Sarai, Sadako Motoyama, Hiroto Harigaya, Hajime Ito, Yoshihiro Sanda, Shankar Biswas, Hirofumi Anno, Junichi Ishii, Toyoaki Murohara, Yukio Ozaki

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Background: The differences in the coronary plaque characteristics between patients with mild chronic kidney disease (CKD) (estimated glomerular filtration rate [eGFR] 30-59 ml · min -1 · 1.73 m -2) and those without CKD (eGFR ≥60) by 320-row area detector computed tomography (CT) have not been studied. Methods and Results: We enrolled 487 patients undergoing coronary CT angiography with suspected stable coronary artery disease (mean age: 66.6±10.8 years, 131 with mild CKD) and analyzed 6,352 segments. All coronary plaques were characterized for the presence of vessel remodeling, plaque consistency and the disposition of coronary calcification, and a plaque with positive vessel remodeling and/or low-attenuation was defined as high risk. The number of diseased segments per patient was higher in mild CKD patients than in those without CKD (4.61±3.83 vs. 2.95±3.11, P<0.0001). The prevalence of severe stenosis (≥70% luminal diameter) was significantly higher in cases of mild CKD than in no CKD (35.1% vs. 19.4%, P=0.0003), but there was no significant difference in the prevalence of high-risk plaque (13.0% vs. 9.8%, P=0.3189). Conclusions: The severity of coronary artery stenosis was higher in the patients with mild CKD, though there was no significant difference in the prevalence of high-risk plaque. We suggest that the high risk of coronary events in patients with CKD is related to the severity of stenosis rather than to the characteristics of plaque.

Original languageEnglish
Pages (from-to)1436-1441
Number of pages6
JournalCirculation Journal
Issue number6
Publication statusPublished - 01-06-2012


All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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