Correlation between an enzyme (glutathione S-transferase-π) and effects of chemotherapy (cisplatin + etoposide)

T. Arai, Y. Yasuda, Y. Ito, K. Hayakawa, T. Takaya, S. Toshima, C. Shibuya, M. Nawada, M. Shibayama, N. Yoshimi, H. Ito, H. Fujiwara

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2 Citations (Scopus)


Objectives: We studied the correlation between cisplatin and etoposide chemotherapy and GST-π staining in patients with untreated primary nonsmall cell lung cancer. Methods: Of patients diagnosed as having primary lung cancer, 27 patients (26 men, 1 woman; median age 74.9 years) with stage IIIb or over were studied. Histological types included squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. A course of treatment consisted of cisplatin 100 mg/m2/day x one day and etoposide 100 mg/m2/day x 3 days during 28 days. After 2 courses of treatment, the therapeutic effects were judged and examined in relation to immunostaining levels obtained with anti- GST-π antibody. Results: Of patients with PR (14), 11 showed GST-π (-) staining. Conclusion: There is a correlation between GST-π staining and the effects of cisplatin and etoposide chemotherapy.

Original languageEnglish
Pages (from-to)881-885
Number of pages5
JournalJapanese Journal of Cancer and Chemotherapy
Issue number7
Publication statusPublished - 1996
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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