Abstract
Objectives: We studied the correlation between cisplatin and etoposide chemotherapy and GST-π staining in patients with untreated primary nonsmall cell lung cancer. Methods: Of patients diagnosed as having primary lung cancer, 27 patients (26 men, 1 woman; median age 74.9 years) with stage IIIb or over were studied. Histological types included squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. A course of treatment consisted of cisplatin 100 mg/m2/day x one day and etoposide 100 mg/m2/day x 3 days during 28 days. After 2 courses of treatment, the therapeutic effects were judged and examined in relation to immunostaining levels obtained with anti- GST-π antibody. Results: Of patients with PR (14), 11 showed GST-π (-) staining. Conclusion: There is a correlation between GST-π staining and the effects of cisplatin and etoposide chemotherapy.
Original language | English |
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Pages (from-to) | 881-885 |
Number of pages | 5 |
Journal | Japanese Journal of Cancer and Chemotherapy |
Volume | 23 |
Issue number | 7 |
Publication status | Published - 1996 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research