Correlation between endothelial CXCR7 expression and clinicopathological factors in oral squamous cell carcinoma

Misa Yanagiya; Randa I.H. Dawood; Nako Maishi; Yasuhiro Hida; Chisaho Torii; Dorcas A. Annan; Hiroshi Kikuchi; Aya Yanagawa Matsuda; Tetsuya Kitamura; Yoichi Ohiro; Masanobu Shindoh; Shinya Tanaka; Yoshimasa Kitagawa; Kyoko Hida

doi:10.1111/pin.13094

Correlation between endothelial CXCR7 expression and clinicopathological factors in oral squamous cell carcinoma

Misa Yanagiya, Randa I.H. Dawood, Nako Maishi, Yasuhiro Hida, Chisaho Torii, Dorcas A. Annan, Hiroshi Kikuchi, Aya Yanagawa Matsuda, Tetsuya Kitamura, Yoichi Ohiro, Masanobu Shindoh, Shinya Tanaka, Yoshimasa Kitagawa, Kyoko Hida

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Oral squamous cell carcinoma (OSCC) impairs functionality and sensuousness resulting in poor quality of life. Biomarkers can predict disease trajectory and lead to effective treatments. Transcriptomics have identified genes that are upregulated in tumor endothelial cells (TECs) compared with normal endothelial cells (NECs). Among them, chemokine receptor 7 (CXCR7) is highly expressed in TECs of several cancers and involved in angiogenesis of TECs. However, levels of CXCR7 in OSCC blood vessels have not been fully investigated. In this study, we analyzed the correlation between CXCR7 expression in TECs and clinicopathological factors in OSCC. Immunohistochemistry for CXCR7 and CD34 was performed on 59 OSCC tissue specimens resected between 1996 and 2008 at Hokkaido University Hospital. CXCR7 expression in blood vessels was evaluated by the ratio of CXCR7+/CD34+ blood vessels. CXCR7 expression was 42% and 19% in tumor and non-tumor parts, respectively, suggesting that CXCR7 expression is higher in TECs than in NECs. CXCR7 expression in TECs correlated with advanced T-stage and cancer stage. Overall survival and disease-free survival rates were higher in low-expressing CXCR7 patients than in high-expressing. These results suggest that CXCR7 expression in blood vessels may be a useful diagnostic and prognostic marker for OSCC patients.

Original language	English
Pages (from-to)	383-391
Number of pages	9
Journal	Pathology International
Volume	71
Issue number	6
DOIs	https://doi.org/10.1111/pin.13094
Publication status	Published - 06-2021
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pathology and Forensic Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/pin.13094

Cite this

Yanagiya, M., Dawood, R. I. H., Maishi, N., Hida, Y., Torii, C., Annan, D. A., Kikuchi, H., Yanagawa Matsuda, A., Kitamura, T., Ohiro, Y., Shindoh, M., Tanaka, S., Kitagawa, Y., & Hida, K. (2021). Correlation between endothelial CXCR7 expression and clinicopathological factors in oral squamous cell carcinoma. Pathology International, 71(6), 383-391. https://doi.org/10.1111/pin.13094

@article{dad2d33070f64c6098a64d0996096fb1,

title = "Correlation between endothelial CXCR7 expression and clinicopathological factors in oral squamous cell carcinoma",

abstract = "Oral squamous cell carcinoma (OSCC) impairs functionality and sensuousness resulting in poor quality of life. Biomarkers can predict disease trajectory and lead to effective treatments. Transcriptomics have identified genes that are upregulated in tumor endothelial cells (TECs) compared with normal endothelial cells (NECs). Among them, chemokine receptor 7 (CXCR7) is highly expressed in TECs of several cancers and involved in angiogenesis of TECs. However, levels of CXCR7 in OSCC blood vessels have not been fully investigated. In this study, we analyzed the correlation between CXCR7 expression in TECs and clinicopathological factors in OSCC. Immunohistochemistry for CXCR7 and CD34 was performed on 59 OSCC tissue specimens resected between 1996 and 2008 at Hokkaido University Hospital. CXCR7 expression in blood vessels was evaluated by the ratio of CXCR7+/CD34+ blood vessels. CXCR7 expression was 42% and 19% in tumor and non-tumor parts, respectively, suggesting that CXCR7 expression is higher in TECs than in NECs. CXCR7 expression in TECs correlated with advanced T-stage and cancer stage. Overall survival and disease-free survival rates were higher in low-expressing CXCR7 patients than in high-expressing. These results suggest that CXCR7 expression in blood vessels may be a useful diagnostic and prognostic marker for OSCC patients.",

author = "Misa Yanagiya and Dawood, {Randa I.H.} and Nako Maishi and Yasuhiro Hida and Chisaho Torii and Annan, {Dorcas A.} and Hiroshi Kikuchi and {Yanagawa Matsuda}, Aya and Tetsuya Kitamura and Yoichi Ohiro and Masanobu Shindoh and Shinya Tanaka and Yoshimasa Kitagawa and Kyoko Hida",

note = "Publisher Copyright: {\textcopyright} 2021 Japanese Society of Pathology and John Wiley & Sons Australia, Ltd",

year = "2021",

month = jun,

doi = "10.1111/pin.13094",

language = "English",

volume = "71",

pages = "383--391",

journal = "Pathology International",

issn = "1320-5463",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "6",

}

Yanagiya, M, Dawood, RIH, Maishi, N, Hida, Y, Torii, C, Annan, DA, Kikuchi, H, Yanagawa Matsuda, A, Kitamura, T, Ohiro, Y, Shindoh, M, Tanaka, S, Kitagawa, Y & Hida, K 2021, 'Correlation between endothelial CXCR7 expression and clinicopathological factors in oral squamous cell carcinoma', Pathology International, vol. 71, no. 6, pp. 383-391. https://doi.org/10.1111/pin.13094

TY - JOUR

T1 - Correlation between endothelial CXCR7 expression and clinicopathological factors in oral squamous cell carcinoma

AU - Yanagiya, Misa

AU - Dawood, Randa I.H.

AU - Maishi, Nako

AU - Hida, Yasuhiro

AU - Torii, Chisaho

AU - Annan, Dorcas A.

AU - Kikuchi, Hiroshi

AU - Yanagawa Matsuda, Aya

AU - Kitamura, Tetsuya

AU - Ohiro, Yoichi

AU - Shindoh, Masanobu

AU - Tanaka, Shinya

AU - Kitagawa, Yoshimasa

AU - Hida, Kyoko

PY - 2021/6

Y1 - 2021/6

N2 - Oral squamous cell carcinoma (OSCC) impairs functionality and sensuousness resulting in poor quality of life. Biomarkers can predict disease trajectory and lead to effective treatments. Transcriptomics have identified genes that are upregulated in tumor endothelial cells (TECs) compared with normal endothelial cells (NECs). Among them, chemokine receptor 7 (CXCR7) is highly expressed in TECs of several cancers and involved in angiogenesis of TECs. However, levels of CXCR7 in OSCC blood vessels have not been fully investigated. In this study, we analyzed the correlation between CXCR7 expression in TECs and clinicopathological factors in OSCC. Immunohistochemistry for CXCR7 and CD34 was performed on 59 OSCC tissue specimens resected between 1996 and 2008 at Hokkaido University Hospital. CXCR7 expression in blood vessels was evaluated by the ratio of CXCR7+/CD34+ blood vessels. CXCR7 expression was 42% and 19% in tumor and non-tumor parts, respectively, suggesting that CXCR7 expression is higher in TECs than in NECs. CXCR7 expression in TECs correlated with advanced T-stage and cancer stage. Overall survival and disease-free survival rates were higher in low-expressing CXCR7 patients than in high-expressing. These results suggest that CXCR7 expression in blood vessels may be a useful diagnostic and prognostic marker for OSCC patients.

AB - Oral squamous cell carcinoma (OSCC) impairs functionality and sensuousness resulting in poor quality of life. Biomarkers can predict disease trajectory and lead to effective treatments. Transcriptomics have identified genes that are upregulated in tumor endothelial cells (TECs) compared with normal endothelial cells (NECs). Among them, chemokine receptor 7 (CXCR7) is highly expressed in TECs of several cancers and involved in angiogenesis of TECs. However, levels of CXCR7 in OSCC blood vessels have not been fully investigated. In this study, we analyzed the correlation between CXCR7 expression in TECs and clinicopathological factors in OSCC. Immunohistochemistry for CXCR7 and CD34 was performed on 59 OSCC tissue specimens resected between 1996 and 2008 at Hokkaido University Hospital. CXCR7 expression in blood vessels was evaluated by the ratio of CXCR7+/CD34+ blood vessels. CXCR7 expression was 42% and 19% in tumor and non-tumor parts, respectively, suggesting that CXCR7 expression is higher in TECs than in NECs. CXCR7 expression in TECs correlated with advanced T-stage and cancer stage. Overall survival and disease-free survival rates were higher in low-expressing CXCR7 patients than in high-expressing. These results suggest that CXCR7 expression in blood vessels may be a useful diagnostic and prognostic marker for OSCC patients.

UR - http://www.scopus.com/inward/record.url?scp=85103369992&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85103369992&partnerID=8YFLogxK

U2 - 10.1111/pin.13094

DO - 10.1111/pin.13094

M3 - Article

C2 - 33783897

AN - SCOPUS:85103369992

SN - 1320-5463

VL - 71

SP - 383

EP - 391

JO - Pathology International

JF - Pathology International

IS - 6

ER -

Correlation between endothelial CXCR7 expression and clinicopathological factors in oral squamous cell carcinoma

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this