Correlation between high-sensitivity C-reactive protein and brain gray matter volume in healthy elderly subjects

Yasuyuki Taki, Benjamin Thyreau, Shigeo Kinomura, Kazunori Sato, Ryoi Goto, Kai Wu, Masako Kakizaki, Ichiro Tsuji, Ryuta Kawashima, Hiroshi Fukuda

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Although elevated serum high-sensitivity C-reactive protein (hsCRP) is related to atherosclerosis, brain infarction, and cognitive decline, it has not been clarified whether increased hsCRP is associated with the decline in brain gray matter volume. Therefore, the purpose of this study was to determine the relationship between hsCRP levels and brain regional gray matter volume using brain magnetic resonance imaging (MRI) data from 109 community-dwelling healthy elderly subjects. Brain MRIs were processed with voxel-based morphometry using a custom template by applying diffeomorphic anatomical registration using the exponentiated lie algebra (DARTEL) procedure. We found a significant negative correlation between regional gray matter volume of the posterior and lateral aspects of the left temporal cortex and hsCRP level after adjusting for age, gender, and intracranial volume. Our results suggest that subjects who have mild inflammation related to arteriosclerosis have decreased regional gray matter volume in the posterior and lateral aspects of the left temporal cortex. Thus, preventing the progression of arteriosclerosis may be important for preventing a decrease in gray matter volume in healthy elderly subjects.

Original languageEnglish
Pages (from-to)2418-2424
Number of pages7
JournalHuman Brain Mapping
Volume34
Issue number10
DOIs
Publication statusPublished - 01-10-2013

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C-Reactive Protein
Healthy Volunteers
Brain
Arteriosclerosis
Temporal Lobe
Brain Infarction
Independent Living
Atherosclerosis
Magnetic Resonance Imaging
Gray Matter
Inflammation
Serum

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Anatomy
  • Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Taki, Y., Thyreau, B., Kinomura, S., Sato, K., Goto, R., Wu, K., ... Fukuda, H. (2013). Correlation between high-sensitivity C-reactive protein and brain gray matter volume in healthy elderly subjects. Human Brain Mapping, 34(10), 2418-2424. https://doi.org/10.1002/hbm.22073
Taki, Yasuyuki ; Thyreau, Benjamin ; Kinomura, Shigeo ; Sato, Kazunori ; Goto, Ryoi ; Wu, Kai ; Kakizaki, Masako ; Tsuji, Ichiro ; Kawashima, Ryuta ; Fukuda, Hiroshi. / Correlation between high-sensitivity C-reactive protein and brain gray matter volume in healthy elderly subjects. In: Human Brain Mapping. 2013 ; Vol. 34, No. 10. pp. 2418-2424.
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Taki, Y, Thyreau, B, Kinomura, S, Sato, K, Goto, R, Wu, K, Kakizaki, M, Tsuji, I, Kawashima, R & Fukuda, H 2013, 'Correlation between high-sensitivity C-reactive protein and brain gray matter volume in healthy elderly subjects', Human Brain Mapping, vol. 34, no. 10, pp. 2418-2424. https://doi.org/10.1002/hbm.22073

Correlation between high-sensitivity C-reactive protein and brain gray matter volume in healthy elderly subjects. / Taki, Yasuyuki; Thyreau, Benjamin; Kinomura, Shigeo; Sato, Kazunori; Goto, Ryoi; Wu, Kai; Kakizaki, Masako; Tsuji, Ichiro; Kawashima, Ryuta; Fukuda, Hiroshi.

In: Human Brain Mapping, Vol. 34, No. 10, 01.10.2013, p. 2418-2424.

Research output: Contribution to journalArticle

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AU - Wu, Kai

AU - Kakizaki, Masako

AU - Tsuji, Ichiro

AU - Kawashima, Ryuta

AU - Fukuda, Hiroshi

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