Correlation between human herpesvirus 6 and 7 infections after living related liver transplantation

Masaru Ihira, Tetsushi Yoshikawa, Kyoko Suzuki, Masahiro Ohashi, Sadao Suga, Katsuhiro Asonuma, Koichi Tanaka, Yoshizo Asano

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7) are closely related to each other. Interaction between the two viruses at the time of primary HHV-7 infection is suggested by in vivo and in vitro studies. However, interaction between the two viruses in organ transplant recipients has not been analyzed. We analyzed serially collected plasma samples obtained from 40 living related liver transplant recipients by serological assay (indirect immunofluorescence assay, IFA) and polymerase chain reaction (PCR). Significant increase or seroconversion of HHV-6 IgG and HHV-7 IgG antibody titers were observed in 45% and 58% of recipients respectively. Positive rate of IgM HHV-6 antibody increased up to 35% at 4 weeks after transplantation. However, no remarkable peak in the positive rate of HHV-7 IgM antibody was demonstrated. HHV-6 DNA and HHV-7 DNA were detected in plasma in 15 (38%) and 16 (40%) of the 40 recipients respectively. HHV-6 DNA was detected in 10 (26%) of the 38 recipients at 2 weeks after transplantation. The positive rate of the virus genome in plasma gradually decreased after that time. HHV-7 DNA was detected in 5 (14%) of the 37 recipients at 2 weeks after transplantation; no obvious peak in the positive rate of HHV-7 DNA was demonstrated. Antibody responses involving both HHV-6 and HHV-7, including either a significant increase in IgG antibody titers of positive identification of IgM antibody were observed in 17 (43%) of the 40 recipients. Thirteen out of the 17 recipients demonstrated concurrent antibody response against both viruses. HHV-7 antibody response preceded the HHV-6 antibody response in 2 of the remaining 4 recipients, whereas the opposite was true in the other 2 recipient. Both HHV-6 and HHV-7 DNA were detected in 7 (18%) of the 40 recipients. In 4 of those 7 recipients, DNA from both viruses was concurrently detected, 3 of whom had HHV-7 DNA repeatedly detected after first detection of the virus DNA. The detection of HHV-7 DNA preceded the detection of HHV-6 DNA in 2 recipients, whereas HHV-6 DNA appeared first in 1 recipient.

Original languageEnglish
Pages (from-to)225-232
Number of pages8
JournalMicrobiology and Immunology
Volume45
Issue number3
DOIs
Publication statusPublished - 01-01-2001

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Human Herpesvirus 7
Human Herpesvirus 6
Liver Transplantation
Infection
DNA
Antibody Formation
Antibodies
Viruses
Immunoglobulin M
DNA Viruses
Immunoglobulin G
Transplantation
Herpesviridae Infections
Indirect Fluorescent Antibody Technique

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Virology

Cite this

Ihira, Masaru ; Yoshikawa, Tetsushi ; Suzuki, Kyoko ; Ohashi, Masahiro ; Suga, Sadao ; Asonuma, Katsuhiro ; Tanaka, Koichi ; Asano, Yoshizo. / Correlation between human herpesvirus 6 and 7 infections after living related liver transplantation. In: Microbiology and Immunology. 2001 ; Vol. 45, No. 3. pp. 225-232.
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abstract = "Human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7) are closely related to each other. Interaction between the two viruses at the time of primary HHV-7 infection is suggested by in vivo and in vitro studies. However, interaction between the two viruses in organ transplant recipients has not been analyzed. We analyzed serially collected plasma samples obtained from 40 living related liver transplant recipients by serological assay (indirect immunofluorescence assay, IFA) and polymerase chain reaction (PCR). Significant increase or seroconversion of HHV-6 IgG and HHV-7 IgG antibody titers were observed in 45{\%} and 58{\%} of recipients respectively. Positive rate of IgM HHV-6 antibody increased up to 35{\%} at 4 weeks after transplantation. However, no remarkable peak in the positive rate of HHV-7 IgM antibody was demonstrated. HHV-6 DNA and HHV-7 DNA were detected in plasma in 15 (38{\%}) and 16 (40{\%}) of the 40 recipients respectively. HHV-6 DNA was detected in 10 (26{\%}) of the 38 recipients at 2 weeks after transplantation. The positive rate of the virus genome in plasma gradually decreased after that time. HHV-7 DNA was detected in 5 (14{\%}) of the 37 recipients at 2 weeks after transplantation; no obvious peak in the positive rate of HHV-7 DNA was demonstrated. Antibody responses involving both HHV-6 and HHV-7, including either a significant increase in IgG antibody titers of positive identification of IgM antibody were observed in 17 (43{\%}) of the 40 recipients. Thirteen out of the 17 recipients demonstrated concurrent antibody response against both viruses. HHV-7 antibody response preceded the HHV-6 antibody response in 2 of the remaining 4 recipients, whereas the opposite was true in the other 2 recipient. Both HHV-6 and HHV-7 DNA were detected in 7 (18{\%}) of the 40 recipients. In 4 of those 7 recipients, DNA from both viruses was concurrently detected, 3 of whom had HHV-7 DNA repeatedly detected after first detection of the virus DNA. The detection of HHV-7 DNA preceded the detection of HHV-6 DNA in 2 recipients, whereas HHV-6 DNA appeared first in 1 recipient.",
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Correlation between human herpesvirus 6 and 7 infections after living related liver transplantation. / Ihira, Masaru; Yoshikawa, Tetsushi; Suzuki, Kyoko; Ohashi, Masahiro; Suga, Sadao; Asonuma, Katsuhiro; Tanaka, Koichi; Asano, Yoshizo.

In: Microbiology and Immunology, Vol. 45, No. 3, 01.01.2001, p. 225-232.

Research output: Contribution to journalArticle

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T1 - Correlation between human herpesvirus 6 and 7 infections after living related liver transplantation

AU - Ihira, Masaru

AU - Yoshikawa, Tetsushi

AU - Suzuki, Kyoko

AU - Ohashi, Masahiro

AU - Suga, Sadao

AU - Asonuma, Katsuhiro

AU - Tanaka, Koichi

AU - Asano, Yoshizo

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