Correlation between magnifying narrow-band imaging endoscopy results and organoid differentiation indicated by cancer cell differentiation and its distribution in depressed-type early gastric carcinoma

Hidezumi Tatematsu, Ryoji Miyahara, Yoshie Shimoyama, Kohei Funasaka, Eizaburou Ohno, Masanao Nakamura, Hiroki Kawashima, Akihiro Itoh, Naoki Ohmiya, Yoshiki Hirooka, Osamu Watanabe, Osamu Maeda, Takafumi Ando, Hidemi Goto

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: A close association between patterns identified by magnifying narrow-band imaging (M-NBI) and histological type has been described. M-NBI patterns were also recently reported to be related to the mucin phenotype; however, detials remain unclear. Materials and Methods: We investigated the cellular differentiation of gastric cancer lesions, along with their mucosal distribution observed by M-NBI. Ninety-seven depressed-type early gastric cancer lesions (74 differentiated and 23 undifferentiated adenocarcinomas) were visualized by M-NBI. Findings were divided into 4 patterns based on abnormal microvascular architecture: a chain loop pattern (CLP), a fine network pattern (FNP), a corkscrew pattern (CSP), and an unclassified pattern. Mucin phenotypes were judged as gastric (G-type), intestinal (I-type), mixed gastric and intestinal (M-type), and null (N-type) based on 4 markers (MAC5AC, MUC6, MUC2, and CD10). The relationship of each pattern of microvascular architecture with organoid differentiation indicated by cancer cell differentiation and its distribution in each histological type of early gastric cancer was investigated. Results: All CLP and FNP lesions were differentiated. The cancer cell distribution showed organoid differentiation in 84.2% (16/19) and 61.1% (22/36) of the two types of lesions, respectively, and there was a significant difference from the unclassified pattern with organoid differentiation (p<0.001). Almost all (94.7%; 18/19) CSP lesions were undifferentiated, and organoid differentiation was observed in 72.2% (13/18). There was a significant difference from the unclassified pattern with organoid differentiation (p<0.05). Conclusions: Cellular differentiation and distribution are associated with microvascular architecture observed by M-NBI.

Original languageEnglish
Pages (from-to)2765-2769
Number of pages5
JournalAsian Pacific Journal of Cancer Prevention
Volume14
Issue number5
DOIs
Publication statusPublished - 01-01-2013
Externally publishedYes

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Narrow Band Imaging
Organoids
Endoscopy
Cell Differentiation
Stomach
Carcinoma
Stomach Neoplasms
Mucins
Neoplasms
Phenotype
Adenocarcinoma

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

Cite this

Tatematsu, Hidezumi ; Miyahara, Ryoji ; Shimoyama, Yoshie ; Funasaka, Kohei ; Ohno, Eizaburou ; Nakamura, Masanao ; Kawashima, Hiroki ; Itoh, Akihiro ; Ohmiya, Naoki ; Hirooka, Yoshiki ; Watanabe, Osamu ; Maeda, Osamu ; Ando, Takafumi ; Goto, Hidemi. / Correlation between magnifying narrow-band imaging endoscopy results and organoid differentiation indicated by cancer cell differentiation and its distribution in depressed-type early gastric carcinoma. In: Asian Pacific Journal of Cancer Prevention. 2013 ; Vol. 14, No. 5. pp. 2765-2769.
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abstract = "Background: A close association between patterns identified by magnifying narrow-band imaging (M-NBI) and histological type has been described. M-NBI patterns were also recently reported to be related to the mucin phenotype; however, detials remain unclear. Materials and Methods: We investigated the cellular differentiation of gastric cancer lesions, along with their mucosal distribution observed by M-NBI. Ninety-seven depressed-type early gastric cancer lesions (74 differentiated and 23 undifferentiated adenocarcinomas) were visualized by M-NBI. Findings were divided into 4 patterns based on abnormal microvascular architecture: a chain loop pattern (CLP), a fine network pattern (FNP), a corkscrew pattern (CSP), and an unclassified pattern. Mucin phenotypes were judged as gastric (G-type), intestinal (I-type), mixed gastric and intestinal (M-type), and null (N-type) based on 4 markers (MAC5AC, MUC6, MUC2, and CD10). The relationship of each pattern of microvascular architecture with organoid differentiation indicated by cancer cell differentiation and its distribution in each histological type of early gastric cancer was investigated. Results: All CLP and FNP lesions were differentiated. The cancer cell distribution showed organoid differentiation in 84.2{\%} (16/19) and 61.1{\%} (22/36) of the two types of lesions, respectively, and there was a significant difference from the unclassified pattern with organoid differentiation (p<0.001). Almost all (94.7{\%}; 18/19) CSP lesions were undifferentiated, and organoid differentiation was observed in 72.2{\%} (13/18). There was a significant difference from the unclassified pattern with organoid differentiation (p<0.05). Conclusions: Cellular differentiation and distribution are associated with microvascular architecture observed by M-NBI.",
author = "Hidezumi Tatematsu and Ryoji Miyahara and Yoshie Shimoyama and Kohei Funasaka and Eizaburou Ohno and Masanao Nakamura and Hiroki Kawashima and Akihiro Itoh and Naoki Ohmiya and Yoshiki Hirooka and Osamu Watanabe and Osamu Maeda and Takafumi Ando and Hidemi Goto",
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Correlation between magnifying narrow-band imaging endoscopy results and organoid differentiation indicated by cancer cell differentiation and its distribution in depressed-type early gastric carcinoma. / Tatematsu, Hidezumi; Miyahara, Ryoji; Shimoyama, Yoshie; Funasaka, Kohei; Ohno, Eizaburou; Nakamura, Masanao; Kawashima, Hiroki; Itoh, Akihiro; Ohmiya, Naoki; Hirooka, Yoshiki; Watanabe, Osamu; Maeda, Osamu; Ando, Takafumi; Goto, Hidemi.

In: Asian Pacific Journal of Cancer Prevention, Vol. 14, No. 5, 01.01.2013, p. 2765-2769.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Correlation between magnifying narrow-band imaging endoscopy results and organoid differentiation indicated by cancer cell differentiation and its distribution in depressed-type early gastric carcinoma

AU - Tatematsu, Hidezumi

AU - Miyahara, Ryoji

AU - Shimoyama, Yoshie

AU - Funasaka, Kohei

AU - Ohno, Eizaburou

AU - Nakamura, Masanao

AU - Kawashima, Hiroki

AU - Itoh, Akihiro

AU - Ohmiya, Naoki

AU - Hirooka, Yoshiki

AU - Watanabe, Osamu

AU - Maeda, Osamu

AU - Ando, Takafumi

AU - Goto, Hidemi

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Background: A close association between patterns identified by magnifying narrow-band imaging (M-NBI) and histological type has been described. M-NBI patterns were also recently reported to be related to the mucin phenotype; however, detials remain unclear. Materials and Methods: We investigated the cellular differentiation of gastric cancer lesions, along with their mucosal distribution observed by M-NBI. Ninety-seven depressed-type early gastric cancer lesions (74 differentiated and 23 undifferentiated adenocarcinomas) were visualized by M-NBI. Findings were divided into 4 patterns based on abnormal microvascular architecture: a chain loop pattern (CLP), a fine network pattern (FNP), a corkscrew pattern (CSP), and an unclassified pattern. Mucin phenotypes were judged as gastric (G-type), intestinal (I-type), mixed gastric and intestinal (M-type), and null (N-type) based on 4 markers (MAC5AC, MUC6, MUC2, and CD10). The relationship of each pattern of microvascular architecture with organoid differentiation indicated by cancer cell differentiation and its distribution in each histological type of early gastric cancer was investigated. Results: All CLP and FNP lesions were differentiated. The cancer cell distribution showed organoid differentiation in 84.2% (16/19) and 61.1% (22/36) of the two types of lesions, respectively, and there was a significant difference from the unclassified pattern with organoid differentiation (p<0.001). Almost all (94.7%; 18/19) CSP lesions were undifferentiated, and organoid differentiation was observed in 72.2% (13/18). There was a significant difference from the unclassified pattern with organoid differentiation (p<0.05). Conclusions: Cellular differentiation and distribution are associated with microvascular architecture observed by M-NBI.

AB - Background: A close association between patterns identified by magnifying narrow-band imaging (M-NBI) and histological type has been described. M-NBI patterns were also recently reported to be related to the mucin phenotype; however, detials remain unclear. Materials and Methods: We investigated the cellular differentiation of gastric cancer lesions, along with their mucosal distribution observed by M-NBI. Ninety-seven depressed-type early gastric cancer lesions (74 differentiated and 23 undifferentiated adenocarcinomas) were visualized by M-NBI. Findings were divided into 4 patterns based on abnormal microvascular architecture: a chain loop pattern (CLP), a fine network pattern (FNP), a corkscrew pattern (CSP), and an unclassified pattern. Mucin phenotypes were judged as gastric (G-type), intestinal (I-type), mixed gastric and intestinal (M-type), and null (N-type) based on 4 markers (MAC5AC, MUC6, MUC2, and CD10). The relationship of each pattern of microvascular architecture with organoid differentiation indicated by cancer cell differentiation and its distribution in each histological type of early gastric cancer was investigated. Results: All CLP and FNP lesions were differentiated. The cancer cell distribution showed organoid differentiation in 84.2% (16/19) and 61.1% (22/36) of the two types of lesions, respectively, and there was a significant difference from the unclassified pattern with organoid differentiation (p<0.001). Almost all (94.7%; 18/19) CSP lesions were undifferentiated, and organoid differentiation was observed in 72.2% (13/18). There was a significant difference from the unclassified pattern with organoid differentiation (p<0.05). Conclusions: Cellular differentiation and distribution are associated with microvascular architecture observed by M-NBI.

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