TY - JOUR
T1 - Correlation between pulmonary function and brain volume in healthy elderly subjects
AU - Taki, Yasuyuki
AU - Kinomura, Shigeo
AU - Ebihara, Satoru
AU - Thyreau, Benjamin
AU - Sato, Kazunori
AU - Goto, Ryoi
AU - Kakizaki, Masako
AU - Tsuji, Ichiro
AU - Kawashima, Ryuta
AU - Fukuda, Hiroshi
N1 - Funding Information:
This Human Brain Project/Neuroinformatics research (ICBM) was funded by the National Institute of Biomedical Imaging and Bioengineering, the National Institute of Neurological Disorders and Stroke, and the National Institute of Mental Health. Part of this research was supported by a grant from the Telecommunications Advancement Organization of Japan, as well as the Japan Society for the Promotion of Science research for the future program (97L00202). This research was also supported by Grants for Scientific Research (13557031) and for JSPS’s Research (1410301) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, and by a research grant (2002) from the Japan Atherosclerosis Prevention Fund, a Health Science Grant on Health Services (H13-kenko-008), and by the Comprehensive Research on Aging and Health (H13-choju-007, H13-choju-023) grants from the Ministry of Health, Labour, and Welfare of Japan. This work was also partially supported by the Ministry of Education, Science, Sports, and Culture, Grants-in-Aid 23240056 and 23390295.
PY - 2013/6
Y1 - 2013/6
N2 - Introduction: Cigarette smoking decreases brain regional gray matter volume and is related to chronic obstructive lung disease (COPD). COPD leads to decreased pulmonary function, which is represented by forced expiratory volume in one second percentage (FEV1.0 %); however, it is unclear if decreased pulmonary function is directly related to brain gray matter volume decline. Because there is a link between COPD and cognitive decline, revealing a direct relationship between pulmonary function and brain structure is important to better understand how pulmonary function affects brain structure and cognitive function. Therefore, the purpose of this study was to analyze whether there were significant correlations between FEV1.0 % and brain regional gray and white matter volumes using brain magnetic resonance (MR) image data from 109 community-dwelling healthy elderly individuals. Methods: Brain MR images were processed with voxel-based morphometry using a custom template by applying diffeomorphic anatomical registration using the exponentiated lie algebra procedure. Results: We found a significant positive correlation between the regional white matter volume of the cerebellum and FEV1.0 % after adjusting for age, sex, and intracranial volume. Conclusion: Our results suggest that elderly individuals who have a lower FEV1.0 % have decreased regional white matter volume in the cerebellum. Therefore, preventing decreased pulmonary function is important for cerebellar white matter volume in the healthy elderly population.
AB - Introduction: Cigarette smoking decreases brain regional gray matter volume and is related to chronic obstructive lung disease (COPD). COPD leads to decreased pulmonary function, which is represented by forced expiratory volume in one second percentage (FEV1.0 %); however, it is unclear if decreased pulmonary function is directly related to brain gray matter volume decline. Because there is a link between COPD and cognitive decline, revealing a direct relationship between pulmonary function and brain structure is important to better understand how pulmonary function affects brain structure and cognitive function. Therefore, the purpose of this study was to analyze whether there were significant correlations between FEV1.0 % and brain regional gray and white matter volumes using brain magnetic resonance (MR) image data from 109 community-dwelling healthy elderly individuals. Methods: Brain MR images were processed with voxel-based morphometry using a custom template by applying diffeomorphic anatomical registration using the exponentiated lie algebra procedure. Results: We found a significant positive correlation between the regional white matter volume of the cerebellum and FEV1.0 % after adjusting for age, sex, and intracranial volume. Conclusion: Our results suggest that elderly individuals who have a lower FEV1.0 % have decreased regional white matter volume in the cerebellum. Therefore, preventing decreased pulmonary function is important for cerebellar white matter volume in the healthy elderly population.
UR - http://www.scopus.com/inward/record.url?scp=84879235869&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84879235869&partnerID=8YFLogxK
U2 - 10.1007/s00234-013-1157-6
DO - 10.1007/s00234-013-1157-6
M3 - Article
C2 - 23440433
AN - SCOPUS:84879235869
SN - 0028-3940
VL - 55
SP - 689
EP - 695
JO - Neuroradiology
JF - Neuroradiology
IS - 6
ER -