Abstract
Background Postprandial hyperlipidemia partially refers to the postprandial accumulation of chylomicrons and chylomicron remnants (CM-R). Many in vitro studies have shown that CM-R has highly atherogenic properties, but consensus is lacking on whether CM-R accumulation correlates with the development of atherosclerotic cardiovascular diseases. We investigated the correlation between CM-R accumulation and the prevalence of coronary artery disease (CAD). Design Subjects who received a coronary angiography and did not take any lipid-lowering drugs (n=189) were enrolled. Subjects with coronary artery stenosis (≥75%) were diagnosed as CAD. Biochemical markers for glucose and lipid metabolism including fasting apolipoprotein (apo) B-48 concentration were compared between CAD patients (n=96) and age-, sex-, and body mass index (BMI)-matched non-CAD subjects without overt coronary stenosis (<75%) (n=67). We tried to determine which metabolic parameters were correlated with the prevalence of CAD by multiple logistic regression analysis, and whether or not the combination of high apo B-48 and other coronary risk factors (high triglyceride, low HDL-C, high HbA1c or low adiponectin levels) increased the prevalence of CAD. Results Fasting serum apo B-48 levels were significantly higher in CAD patients than in non-CAD subjects (3·9±2·4 vs. 6·9±2·6μg/mL, P<0·0001) and had the most significant correlation with the existence of CAD. The clustering of high fasting apo B-48 levels (>4·34μg/mL, the cut-off value) and other coronary risk factors were found to be associated with a stronger risk of CAD compared with single high fasting apo B-48 levels. Conclusion Fasting serum apo B-48 levels significantly correlated with the prevalence of CAD.
| Original language | English |
|---|---|
| Pages (from-to) | 992-999 |
| Number of pages | 8 |
| Journal | European Journal of Clinical Investigation |
| Volume | 42 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 01-09-2012 |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
- Biochemistry
- Clinical Biochemistry
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Correlation of fasting serum apolipoprotein B-48 with coronary artery disease prevalence. / Masuda, Daisaku; Sugimoto, Taizo; Tsujii, Ken ichi; Inagaki, Miwako; Nakatani, Kazuhiro; Yuasa-Kawase, Miyako; Tsubakio-Yamamoto, Kazumi; Ohama, Tohru; Nishida, Makoto; Ishigami, Masato; Kawamoto, Toshiharu; Matsuyama, Akifumi; Sakai, Naohiko; Komuro, Issei; Yamashita, Shizuya.
In: European Journal of Clinical Investigation, Vol. 42, No. 9, 01.09.2012, p. 992-999.Research output: Contribution to journal › Article
TY - JOUR
T1 - Correlation of fasting serum apolipoprotein B-48 with coronary artery disease prevalence
AU - Masuda, Daisaku
AU - Sugimoto, Taizo
AU - Tsujii, Ken ichi
AU - Inagaki, Miwako
AU - Nakatani, Kazuhiro
AU - Yuasa-Kawase, Miyako
AU - Tsubakio-Yamamoto, Kazumi
AU - Ohama, Tohru
AU - Nishida, Makoto
AU - Ishigami, Masato
AU - Kawamoto, Toshiharu
AU - Matsuyama, Akifumi
AU - Sakai, Naohiko
AU - Komuro, Issei
AU - Yamashita, Shizuya
PY - 2012/9/1
Y1 - 2012/9/1
N2 - Background Postprandial hyperlipidemia partially refers to the postprandial accumulation of chylomicrons and chylomicron remnants (CM-R). Many in vitro studies have shown that CM-R has highly atherogenic properties, but consensus is lacking on whether CM-R accumulation correlates with the development of atherosclerotic cardiovascular diseases. We investigated the correlation between CM-R accumulation and the prevalence of coronary artery disease (CAD). Design Subjects who received a coronary angiography and did not take any lipid-lowering drugs (n=189) were enrolled. Subjects with coronary artery stenosis (≥75%) were diagnosed as CAD. Biochemical markers for glucose and lipid metabolism including fasting apolipoprotein (apo) B-48 concentration were compared between CAD patients (n=96) and age-, sex-, and body mass index (BMI)-matched non-CAD subjects without overt coronary stenosis (<75%) (n=67). We tried to determine which metabolic parameters were correlated with the prevalence of CAD by multiple logistic regression analysis, and whether or not the combination of high apo B-48 and other coronary risk factors (high triglyceride, low HDL-C, high HbA1c or low adiponectin levels) increased the prevalence of CAD. Results Fasting serum apo B-48 levels were significantly higher in CAD patients than in non-CAD subjects (3·9±2·4 vs. 6·9±2·6μg/mL, P<0·0001) and had the most significant correlation with the existence of CAD. The clustering of high fasting apo B-48 levels (>4·34μg/mL, the cut-off value) and other coronary risk factors were found to be associated with a stronger risk of CAD compared with single high fasting apo B-48 levels. Conclusion Fasting serum apo B-48 levels significantly correlated with the prevalence of CAD.
AB - Background Postprandial hyperlipidemia partially refers to the postprandial accumulation of chylomicrons and chylomicron remnants (CM-R). Many in vitro studies have shown that CM-R has highly atherogenic properties, but consensus is lacking on whether CM-R accumulation correlates with the development of atherosclerotic cardiovascular diseases. We investigated the correlation between CM-R accumulation and the prevalence of coronary artery disease (CAD). Design Subjects who received a coronary angiography and did not take any lipid-lowering drugs (n=189) were enrolled. Subjects with coronary artery stenosis (≥75%) were diagnosed as CAD. Biochemical markers for glucose and lipid metabolism including fasting apolipoprotein (apo) B-48 concentration were compared between CAD patients (n=96) and age-, sex-, and body mass index (BMI)-matched non-CAD subjects without overt coronary stenosis (<75%) (n=67). We tried to determine which metabolic parameters were correlated with the prevalence of CAD by multiple logistic regression analysis, and whether or not the combination of high apo B-48 and other coronary risk factors (high triglyceride, low HDL-C, high HbA1c or low adiponectin levels) increased the prevalence of CAD. Results Fasting serum apo B-48 levels were significantly higher in CAD patients than in non-CAD subjects (3·9±2·4 vs. 6·9±2·6μg/mL, P<0·0001) and had the most significant correlation with the existence of CAD. The clustering of high fasting apo B-48 levels (>4·34μg/mL, the cut-off value) and other coronary risk factors were found to be associated with a stronger risk of CAD compared with single high fasting apo B-48 levels. Conclusion Fasting serum apo B-48 levels significantly correlated with the prevalence of CAD.
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U2 - 10.1111/j.1365-2362.2012.02687.x
DO - 10.1111/j.1365-2362.2012.02687.x
M3 - Article
VL - 42
SP - 992
EP - 999
JO - European Journal of Clinical Investigation
JF - European Journal of Clinical Investigation
SN - 0014-2972
IS - 9
ER -