Correlation of fasting serum apolipoprotein B-48 with coronary artery disease prevalence

Daisaku Masuda, Taizo Sugimoto, Ken ichi Tsujii, Miwako Inagaki, Kazuhiro Nakatani, Miyako Yuasa-Kawase, Kazumi Tsubakio-Yamamoto, Tohru Ohama, Makoto Nishida, Masato Ishigami, Toshiharu Kawamoto, Akifumi Matsuyama, Naohiko Sakai, Issei Komuro, Shizuya Yamashita

Research output: Contribution to journalArticle

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Abstract

Background Postprandial hyperlipidemia partially refers to the postprandial accumulation of chylomicrons and chylomicron remnants (CM-R). Many in vitro studies have shown that CM-R has highly atherogenic properties, but consensus is lacking on whether CM-R accumulation correlates with the development of atherosclerotic cardiovascular diseases. We investigated the correlation between CM-R accumulation and the prevalence of coronary artery disease (CAD). Design Subjects who received a coronary angiography and did not take any lipid-lowering drugs (n=189) were enrolled. Subjects with coronary artery stenosis (≥75%) were diagnosed as CAD. Biochemical markers for glucose and lipid metabolism including fasting apolipoprotein (apo) B-48 concentration were compared between CAD patients (n=96) and age-, sex-, and body mass index (BMI)-matched non-CAD subjects without overt coronary stenosis (<75%) (n=67). We tried to determine which metabolic parameters were correlated with the prevalence of CAD by multiple logistic regression analysis, and whether or not the combination of high apo B-48 and other coronary risk factors (high triglyceride, low HDL-C, high HbA1c or low adiponectin levels) increased the prevalence of CAD. Results Fasting serum apo B-48 levels were significantly higher in CAD patients than in non-CAD subjects (3·9±2·4 vs. 6·9±2·6μg/mL, P<0·0001) and had the most significant correlation with the existence of CAD. The clustering of high fasting apo B-48 levels (>4·34μg/mL, the cut-off value) and other coronary risk factors were found to be associated with a stronger risk of CAD compared with single high fasting apo B-48 levels. Conclusion Fasting serum apo B-48 levels significantly correlated with the prevalence of CAD.

Original languageEnglish
Pages (from-to)992-999
Number of pages8
JournalEuropean Journal of Clinical Investigation
Volume42
Issue number9
DOIs
Publication statusPublished - 01-09-2012

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Apolipoprotein B-48
Chylomicron Remnants
Coronary Artery Disease
Fasting
Serum
Coronary Stenosis
Chylomicrons
Hyperlipidemias
Coronary Angiography
Lipid Metabolism
Angiography
Consensus
Body Mass Index
Cardiovascular Diseases
Arteries
Biomarkers
Lipids
Glucose
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Biochemistry
  • Clinical Biochemistry

Cite this

Masuda, D., Sugimoto, T., Tsujii, K. I., Inagaki, M., Nakatani, K., Yuasa-Kawase, M., ... Yamashita, S. (2012). Correlation of fasting serum apolipoprotein B-48 with coronary artery disease prevalence. European Journal of Clinical Investigation, 42(9), 992-999. https://doi.org/10.1111/j.1365-2362.2012.02687.x
Masuda, Daisaku ; Sugimoto, Taizo ; Tsujii, Ken ichi ; Inagaki, Miwako ; Nakatani, Kazuhiro ; Yuasa-Kawase, Miyako ; Tsubakio-Yamamoto, Kazumi ; Ohama, Tohru ; Nishida, Makoto ; Ishigami, Masato ; Kawamoto, Toshiharu ; Matsuyama, Akifumi ; Sakai, Naohiko ; Komuro, Issei ; Yamashita, Shizuya. / Correlation of fasting serum apolipoprotein B-48 with coronary artery disease prevalence. In: European Journal of Clinical Investigation. 2012 ; Vol. 42, No. 9. pp. 992-999.
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abstract = "Background Postprandial hyperlipidemia partially refers to the postprandial accumulation of chylomicrons and chylomicron remnants (CM-R). Many in vitro studies have shown that CM-R has highly atherogenic properties, but consensus is lacking on whether CM-R accumulation correlates with the development of atherosclerotic cardiovascular diseases. We investigated the correlation between CM-R accumulation and the prevalence of coronary artery disease (CAD). Design Subjects who received a coronary angiography and did not take any lipid-lowering drugs (n=189) were enrolled. Subjects with coronary artery stenosis (≥75{\%}) were diagnosed as CAD. Biochemical markers for glucose and lipid metabolism including fasting apolipoprotein (apo) B-48 concentration were compared between CAD patients (n=96) and age-, sex-, and body mass index (BMI)-matched non-CAD subjects without overt coronary stenosis (<75{\%}) (n=67). We tried to determine which metabolic parameters were correlated with the prevalence of CAD by multiple logistic regression analysis, and whether or not the combination of high apo B-48 and other coronary risk factors (high triglyceride, low HDL-C, high HbA1c or low adiponectin levels) increased the prevalence of CAD. Results Fasting serum apo B-48 levels were significantly higher in CAD patients than in non-CAD subjects (3·9±2·4 vs. 6·9±2·6μg/mL, P<0·0001) and had the most significant correlation with the existence of CAD. The clustering of high fasting apo B-48 levels (>4·34μg/mL, the cut-off value) and other coronary risk factors were found to be associated with a stronger risk of CAD compared with single high fasting apo B-48 levels. Conclusion Fasting serum apo B-48 levels significantly correlated with the prevalence of CAD.",
author = "Daisaku Masuda and Taizo Sugimoto and Tsujii, {Ken ichi} and Miwako Inagaki and Kazuhiro Nakatani and Miyako Yuasa-Kawase and Kazumi Tsubakio-Yamamoto and Tohru Ohama and Makoto Nishida and Masato Ishigami and Toshiharu Kawamoto and Akifumi Matsuyama and Naohiko Sakai and Issei Komuro and Shizuya Yamashita",
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Masuda, D, Sugimoto, T, Tsujii, KI, Inagaki, M, Nakatani, K, Yuasa-Kawase, M, Tsubakio-Yamamoto, K, Ohama, T, Nishida, M, Ishigami, M, Kawamoto, T, Matsuyama, A, Sakai, N, Komuro, I & Yamashita, S 2012, 'Correlation of fasting serum apolipoprotein B-48 with coronary artery disease prevalence', European Journal of Clinical Investigation, vol. 42, no. 9, pp. 992-999. https://doi.org/10.1111/j.1365-2362.2012.02687.x

Correlation of fasting serum apolipoprotein B-48 with coronary artery disease prevalence. / Masuda, Daisaku; Sugimoto, Taizo; Tsujii, Ken ichi; Inagaki, Miwako; Nakatani, Kazuhiro; Yuasa-Kawase, Miyako; Tsubakio-Yamamoto, Kazumi; Ohama, Tohru; Nishida, Makoto; Ishigami, Masato; Kawamoto, Toshiharu; Matsuyama, Akifumi; Sakai, Naohiko; Komuro, Issei; Yamashita, Shizuya.

In: European Journal of Clinical Investigation, Vol. 42, No. 9, 01.09.2012, p. 992-999.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Correlation of fasting serum apolipoprotein B-48 with coronary artery disease prevalence

AU - Masuda, Daisaku

AU - Sugimoto, Taizo

AU - Tsujii, Ken ichi

AU - Inagaki, Miwako

AU - Nakatani, Kazuhiro

AU - Yuasa-Kawase, Miyako

AU - Tsubakio-Yamamoto, Kazumi

AU - Ohama, Tohru

AU - Nishida, Makoto

AU - Ishigami, Masato

AU - Kawamoto, Toshiharu

AU - Matsuyama, Akifumi

AU - Sakai, Naohiko

AU - Komuro, Issei

AU - Yamashita, Shizuya

PY - 2012/9/1

Y1 - 2012/9/1

N2 - Background Postprandial hyperlipidemia partially refers to the postprandial accumulation of chylomicrons and chylomicron remnants (CM-R). Many in vitro studies have shown that CM-R has highly atherogenic properties, but consensus is lacking on whether CM-R accumulation correlates with the development of atherosclerotic cardiovascular diseases. We investigated the correlation between CM-R accumulation and the prevalence of coronary artery disease (CAD). Design Subjects who received a coronary angiography and did not take any lipid-lowering drugs (n=189) were enrolled. Subjects with coronary artery stenosis (≥75%) were diagnosed as CAD. Biochemical markers for glucose and lipid metabolism including fasting apolipoprotein (apo) B-48 concentration were compared between CAD patients (n=96) and age-, sex-, and body mass index (BMI)-matched non-CAD subjects without overt coronary stenosis (<75%) (n=67). We tried to determine which metabolic parameters were correlated with the prevalence of CAD by multiple logistic regression analysis, and whether or not the combination of high apo B-48 and other coronary risk factors (high triglyceride, low HDL-C, high HbA1c or low adiponectin levels) increased the prevalence of CAD. Results Fasting serum apo B-48 levels were significantly higher in CAD patients than in non-CAD subjects (3·9±2·4 vs. 6·9±2·6μg/mL, P<0·0001) and had the most significant correlation with the existence of CAD. The clustering of high fasting apo B-48 levels (>4·34μg/mL, the cut-off value) and other coronary risk factors were found to be associated with a stronger risk of CAD compared with single high fasting apo B-48 levels. Conclusion Fasting serum apo B-48 levels significantly correlated with the prevalence of CAD.

AB - Background Postprandial hyperlipidemia partially refers to the postprandial accumulation of chylomicrons and chylomicron remnants (CM-R). Many in vitro studies have shown that CM-R has highly atherogenic properties, but consensus is lacking on whether CM-R accumulation correlates with the development of atherosclerotic cardiovascular diseases. We investigated the correlation between CM-R accumulation and the prevalence of coronary artery disease (CAD). Design Subjects who received a coronary angiography and did not take any lipid-lowering drugs (n=189) were enrolled. Subjects with coronary artery stenosis (≥75%) were diagnosed as CAD. Biochemical markers for glucose and lipid metabolism including fasting apolipoprotein (apo) B-48 concentration were compared between CAD patients (n=96) and age-, sex-, and body mass index (BMI)-matched non-CAD subjects without overt coronary stenosis (<75%) (n=67). We tried to determine which metabolic parameters were correlated with the prevalence of CAD by multiple logistic regression analysis, and whether or not the combination of high apo B-48 and other coronary risk factors (high triglyceride, low HDL-C, high HbA1c or low adiponectin levels) increased the prevalence of CAD. Results Fasting serum apo B-48 levels were significantly higher in CAD patients than in non-CAD subjects (3·9±2·4 vs. 6·9±2·6μg/mL, P<0·0001) and had the most significant correlation with the existence of CAD. The clustering of high fasting apo B-48 levels (>4·34μg/mL, the cut-off value) and other coronary risk factors were found to be associated with a stronger risk of CAD compared with single high fasting apo B-48 levels. Conclusion Fasting serum apo B-48 levels significantly correlated with the prevalence of CAD.

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U2 - 10.1111/j.1365-2362.2012.02687.x

DO - 10.1111/j.1365-2362.2012.02687.x

M3 - Article

VL - 42

SP - 992

EP - 999

JO - European Journal of Clinical Investigation

JF - European Journal of Clinical Investigation

SN - 0014-2972

IS - 9

ER -