Correlation of IgE autoantibody to BP180 with a severe form of bullous pemphigoid

Yohei Iwata, Kazuhiro Komura, Masanari Kodera, Toshikazu Usuda, Yoko Yokoyama, Toshihide Hara, Eiji Muroi, Fumihide Ogawa, Motoi Takenaka, Shinichi Sato

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

Objective: To determine the prevalence, immunoglobulin subclass distribution, and clinical correlation of antibodies (Abs), especially of IgE Abs, to BP180 and BP230 in patients with bullous pemphigoid (BP). Design: Retrospective case series analysis. Setting: Department of Dermatology, Nagasaki University Graduate School of Biomedical Science. Patients: Serum samples from 37 patients with BP, 6 with pemphigus vulgaris, 5 with pemphigus foliaceus, and 26 healthy controls (n=26) were examined by enzyme-linked immunosorbent assay. Main Outcome Measures: Prevalence, immunoglobulin subclass distribution, and clinical correlation of Abs, especially of IgE Abs, to BP180 and BP230. Results: IgG anti-BP180 and anti-BP230 Abs were detected in 35 (95%) and 26 (70%) of the 37 BP serum samples, respectively. IgG1 and IgG4 isotypes were positive in 32 (87%) and 25 (68%), respectively, of the BP serum samples for anti-BP180 Abs, while they were detected in 16 (44%) and 26 (70%), respectively, for anti-BP230 Abs. IgE anti-BP180 and anti-BP230 Abs were equally detected in 8 (22%) of the BP serum samples. Similar to IgG anti-BP180 Abs, the presence or levels of IgE anti-BP180 Abs was associated with broader skin lesions. Furthermore, patients with BP positive for IgE anti-BP180 Abs required longer duration for remission, higher dosage of prednisolone, and more intensive therapies for remission. By contrast, this was not true for those with of IgE anti-BP230 Abs. Remarkably, when analyzed in patients with BP who had a high titer of IgG anti-BP180 Abs, the presence or levels of IgE anti-BP180 Abs, but not IgG anti-BP180 Abs, were associated with a more severe form. Conclusions: The present study suggests that IgE anti-BP180 Abs are related to the disease severity and activity of BP. Moreover, it may be possible to identify treatment-refractory patients with BP more specifically by assessing the presence or levels of IgE anti-BP180 Abs in those with a high IgG anti-BP180 Ab titer.

Original languageEnglish
Pages (from-to)41-48
Number of pages8
JournalArchives of Dermatology
Volume144
Issue number1
DOIs
Publication statusPublished - 01-2008

All Science Journal Classification (ASJC) codes

  • Dermatology

Fingerprint Dive into the research topics of 'Correlation of IgE autoantibody to BP180 with a severe form of bullous pemphigoid'. Together they form a unique fingerprint.

  • Cite this

    Iwata, Y., Komura, K., Kodera, M., Usuda, T., Yokoyama, Y., Hara, T., Muroi, E., Ogawa, F., Takenaka, M., & Sato, S. (2008). Correlation of IgE autoantibody to BP180 with a severe form of bullous pemphigoid. Archives of Dermatology, 144(1), 41-48. https://doi.org/10.1001/archdermatol.2007.9