TY - JOUR
T1 - Cortical networks recruited for time perception
T2 - A monkey positron emission tomography (PET) study
AU - Onoe, Hirotaka
AU - Komori, Masashi
AU - Onoe, Kayo
AU - Takechi, Hajime
AU - Tsukada, Hideo
AU - Watanabe, Yasuyoshi
N1 - Funding Information:
The authors thank Dr. M. Watanabe of the Tokyo Metropolitan Institute for Neuroscience for his thoughtful discussions and critical reading of manuscript. We also thank Dr. H. Fukuyama of Kyoto University for his helpful comments about SPM analysis and Mr. T. Hiruma, President of Hamamatsu Photonics K. K., for his organizational support and continued commitment to the research of the PET team in Hamamatsu, and Messrs. H. Shizuno, T. Kakiuchi, and S. Nishiyama of Hamamatsu Photonics for their technical assistance in performing the PET studies. This work was supported in part by Research for the Future Program (RFTF) JSPS-RFTF 98L00201 from the Japan Society for the Promotion of Science (JSPS). The initial phase of this work was supported in part by the Subfemtomole Biorecognition Project, ICORP, Japan Science and Technology Corporation (JST).
PY - 2001
Y1 - 2001
N2 - The presence of an "internal clock" in the brain has been assumed to underlie the information processing related to time. This clock plays a critical role in time keeping and time perception, which are closely associated with integrated functions in the brain. To identify the brain areas recruited for time keeping and time perception, we performed positron emission tomography (PET) studies with rhesus monkeys to measure regional cerebral blood flow (rCBF) as an index of neural activity during time discrimination tasks of different durations ranging from 400 to 1500 ms. Changes in rCBF that covaried significantly with the durations of the target being perceived by subjects were found in the dorsolateral prefrontal cortex (DLPFC), the posterior part of the inferior parietal cortex, basal ganglia, and posterior cingulate cortex. Furthermore, a loss of neuronal function in the DLPFC caused by a local application of bicuculline resulted in the selective reduction of performance in time discrimination tasks. The results indicate that a neural network composed of the posterior inferior parietal cortex to the DLPFC plays a crucial role in the temporal monitoring process in time perception.
AB - The presence of an "internal clock" in the brain has been assumed to underlie the information processing related to time. This clock plays a critical role in time keeping and time perception, which are closely associated with integrated functions in the brain. To identify the brain areas recruited for time keeping and time perception, we performed positron emission tomography (PET) studies with rhesus monkeys to measure regional cerebral blood flow (rCBF) as an index of neural activity during time discrimination tasks of different durations ranging from 400 to 1500 ms. Changes in rCBF that covaried significantly with the durations of the target being perceived by subjects were found in the dorsolateral prefrontal cortex (DLPFC), the posterior part of the inferior parietal cortex, basal ganglia, and posterior cingulate cortex. Furthermore, a loss of neuronal function in the DLPFC caused by a local application of bicuculline resulted in the selective reduction of performance in time discrimination tasks. The results indicate that a neural network composed of the posterior inferior parietal cortex to the DLPFC plays a crucial role in the temporal monitoring process in time perception.
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U2 - 10.1006/nimg.2000.0670
DO - 10.1006/nimg.2000.0670
M3 - Article
C2 - 11133307
AN - SCOPUS:0035722798
VL - 13
SP - 37
EP - 45
JO - NeuroImage
JF - NeuroImage
SN - 1053-8119
IS - 1
ER -