Creatine kinase BB and neuron specific r-enolase as biomarkers for lung cancer

A. Usui, K. Fujita, M. Imaizumi, T. Abe, K. Inoue, S. Matsumoto, K. Kato

Research output: Contribution to journalArticlepeer-review


The serum concentrations of both CK-BB and NSE in patients with various lung carcinoma have been determined by the enzyme immunoassay. Serum CK-BB levels were found to be significantly increased (less than 1.0 ng/ml) in patients with a small cell carcinoma (51 cases, 74.5%), adenocarcinoma (77 cases, 36.5%), and a squamous cell carcinoma (68 cases, 39.7%). The serum NSE levels also were increased (less than 6.0 ng/ml) in cases of small cell carcinoma (72.5%), adenocarcinoma (27.3%), and squamous cell carcinoma (26.5%). Since the serum concentrations of bos CK-BB and NSE changed in parallel with the clinical course, they may be useful biomarkers for monitoring the clinical course of patients with lung cancer, especially in cases of small cell carcinoma.

Original languageEnglish
Pages (from-to)1763-1770
Number of pages8
JournalGan no rinsho. Japan journal of cancer clinics
Issue number14
Publication statusPublished - 11-1987
Externally publishedYes


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