Cripto-1: An embryonic gene that promotes tumorigenesis

Nadia Pereira De Castro, Maria Cristina Rangel, Tadahiro Nagaoka, David S. Salomon, Caterina Bianco

Research output: Contribution to journalReview article

37 Citations (Scopus)

Abstract

Several studies have shown that cell fate regulation during embryonic development and oncogenic transformation share common regulatory mechanisms and signaling pathways. Indeed, an embryonic gene member of the EGF-Cripto-1/FRL1/ Cryptic family, Cripto-1, has been implicated in embryogenesis and in carcinogenesis. Cripto-1 together with the TGF- ligand Nodal is a key regulator of embryonic development and is a marker of undifferentiated human and mouse embryonic stem cells. While Cripto-1 expression is very low in normal adult tissues, Cripto-1 is re-expressed at high levels in several different human tumors, modulating cancer cell proliferation, migration, epithelial-to- mesenchymal transition and stimulating tumor angiogenesis. Therefore, inhibition of Cripto-1 expression using blocking antibodies or antisense expression vectors might be a useful modality not only to target fully differentiated cancer cells but also to target a subpopulation of tumor cells with stem-like characteristics.

Original languageEnglish
Pages (from-to)1127-1142
Number of pages16
JournalFuture Oncology
Volume6
Issue number7
DOIs
Publication statusPublished - 01-07-2010
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

De Castro, N. P., Rangel, M. C., Nagaoka, T., Salomon, D. S., & Bianco, C. (2010). Cripto-1: An embryonic gene that promotes tumorigenesis. Future Oncology, 6(7), 1127-1142. https://doi.org/10.2217/fon.10.68