Critical national shortage of cefazolin in japan: Management strategies

Hitoshi Honda, Shutaro Murakami, Yasuharu Tokuda, Yasuaki Tagashira, Akane Takamatsu

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


The shortage of antimicrobials poses a global health threat. In Japan, for instance, the current, critical shortage of cefazolin, a firstline agent for the treatment of common infectious diseases and surgical antimicrobial prophylaxis, has had a substantial impact on inpatient care. A shortage of essential antimicrobial agents like cefazolin leads to increased consumption of alternative antimicrobial agents with broad-spectrum activity, with the unintended consequence of militating against antimicrobial stewardship efforts in inpatient settings and potentially promoting antimicrobial resistance. Although there is global awareness of the shortage of crucial antimicrobials, action to resolve this problem, especially with a view to preventing antimicrobial resistance and promoting antimicrobial stewardship, has been slow, possibly due to the failure to appreciate the urgency of the dilemma. A comprehensive plan for stabilizing antimicrobial access and international collaboration to secure a continuous supply of essential antimicrobials are urgently needed.

Original languageEnglish
Pages (from-to)1783-1789
Number of pages7
JournalClinical Infectious Diseases
Issue number7
Publication statusPublished - 01-10-2020
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases


Dive into the research topics of 'Critical national shortage of cefazolin in japan: Management strategies'. Together they form a unique fingerprint.

Cite this