TY - JOUR
T1 - Critical national shortage of cefazolin in japan
T2 - Management strategies
AU - Honda, Hitoshi
AU - Murakami, Shutaro
AU - Tokuda, Yasuharu
AU - Tagashira, Yasuaki
AU - Takamatsu, Akane
N1 - Publisher Copyright:
© The Author(s) 2020.
PY - 2020/10/1
Y1 - 2020/10/1
N2 - The shortage of antimicrobials poses a global health threat. In Japan, for instance, the current, critical shortage of cefazolin, a firstline agent for the treatment of common infectious diseases and surgical antimicrobial prophylaxis, has had a substantial impact on inpatient care. A shortage of essential antimicrobial agents like cefazolin leads to increased consumption of alternative antimicrobial agents with broad-spectrum activity, with the unintended consequence of militating against antimicrobial stewardship efforts in inpatient settings and potentially promoting antimicrobial resistance. Although there is global awareness of the shortage of crucial antimicrobials, action to resolve this problem, especially with a view to preventing antimicrobial resistance and promoting antimicrobial stewardship, has been slow, possibly due to the failure to appreciate the urgency of the dilemma. A comprehensive plan for stabilizing antimicrobial access and international collaboration to secure a continuous supply of essential antimicrobials are urgently needed.
AB - The shortage of antimicrobials poses a global health threat. In Japan, for instance, the current, critical shortage of cefazolin, a firstline agent for the treatment of common infectious diseases and surgical antimicrobial prophylaxis, has had a substantial impact on inpatient care. A shortage of essential antimicrobial agents like cefazolin leads to increased consumption of alternative antimicrobial agents with broad-spectrum activity, with the unintended consequence of militating against antimicrobial stewardship efforts in inpatient settings and potentially promoting antimicrobial resistance. Although there is global awareness of the shortage of crucial antimicrobials, action to resolve this problem, especially with a view to preventing antimicrobial resistance and promoting antimicrobial stewardship, has been slow, possibly due to the failure to appreciate the urgency of the dilemma. A comprehensive plan for stabilizing antimicrobial access and international collaboration to secure a continuous supply of essential antimicrobials are urgently needed.
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U2 - 10.1093/cid/ciaa216
DO - 10.1093/cid/ciaa216
M3 - Article
C2 - 32133482
AN - SCOPUS:85094684797
SN - 1058-4838
VL - 71
SP - 1783
EP - 1789
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 7
ER -