TY - JOUR
T1 - Cross sensitization between phencyclidine and methamphetamine
T2 - II repeated administration of methamphetamine at a high dose
AU - Nabeshima, T.
AU - Fukaya, H.
AU - Kamei, H.
AU - Ishikawa, K.
AU - Furukawa, H.
AU - Kameyama, T.
PY - 1989
Y1 - 1989
N2 - We investigated whether effects of phencyclidine (PCP) were modified by repeated pretreatment with methamphetamine (MAP) at a high (15mg/kg/day for 4 days) dose in rats. The incidence of turning, head-weaving and backpedalling induced by PCP was increased by pretreatment with MAP. In the rats pre-treated with MAP, 1) behavioral responses induced by acute MAP, apomorphine and 5-methoxy-N,N-dimethyltryptamine were potentiated; 2) dopamine content in the striatum, nucleus accumbens and frontal cortex and serotonin content in the striatum and frontal cortex were decreased; and 3) the Bmax and Kd values for [3H]-spiperone and [3H]-ketanserin bindings to brain synaptic membrane were significantly increased. These results suggest that 4 days-repeated administration of MAP (15 mg/kg) increases postsynaptic activity of both dopaminergic and serotonergic neuronal systems, and that there may be cross sensitization to PCP in the dopaminergic neuronal function following repeated administration of MAP at high dose.
AB - We investigated whether effects of phencyclidine (PCP) were modified by repeated pretreatment with methamphetamine (MAP) at a high (15mg/kg/day for 4 days) dose in rats. The incidence of turning, head-weaving and backpedalling induced by PCP was increased by pretreatment with MAP. In the rats pre-treated with MAP, 1) behavioral responses induced by acute MAP, apomorphine and 5-methoxy-N,N-dimethyltryptamine were potentiated; 2) dopamine content in the striatum, nucleus accumbens and frontal cortex and serotonin content in the striatum and frontal cortex were decreased; and 3) the Bmax and Kd values for [3H]-spiperone and [3H]-ketanserin bindings to brain synaptic membrane were significantly increased. These results suggest that 4 days-repeated administration of MAP (15 mg/kg) increases postsynaptic activity of both dopaminergic and serotonergic neuronal systems, and that there may be cross sensitization to PCP in the dopaminergic neuronal function following repeated administration of MAP at high dose.
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M3 - Article
AN - SCOPUS:0024365742
SN - 0193-0818
VL - 10
SP - 95
EP - 107
JO - Research Communications in Substances of Abuse
JF - Research Communications in Substances of Abuse
IS - 2
ER -