Cross sensitization between phencyclidine and methamphetamine

II repeated administration of methamphetamine at a high dose

Toshitaka Nabeshima, H. Fukaya, H. Kamei, K. Ishikawa, H. Furukawa, T. Kameyama

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We investigated whether effects of phencyclidine (PCP) were modified by repeated pretreatment with methamphetamine (MAP) at a high (15mg/kg/day for 4 days) dose in rats. The incidence of turning, head-weaving and backpedalling induced by PCP was increased by pretreatment with MAP. In the rats pre-treated with MAP, 1) behavioral responses induced by acute MAP, apomorphine and 5-methoxy-N,N-dimethyltryptamine were potentiated; 2) dopamine content in the striatum, nucleus accumbens and frontal cortex and serotonin content in the striatum and frontal cortex were decreased; and 3) the Bmax and Kd values for [3H]-spiperone and [3H]-ketanserin bindings to brain synaptic membrane were significantly increased. These results suggest that 4 days-repeated administration of MAP (15 mg/kg) increases postsynaptic activity of both dopaminergic and serotonergic neuronal systems, and that there may be cross sensitization to PCP in the dopaminergic neuronal function following repeated administration of MAP at high dose.

Original languageEnglish
Pages (from-to)95-107
Number of pages13
JournalResearch Communications in Substances of Abuse
Volume10
Issue number2
Publication statusPublished - 01-01-1989
Externally publishedYes

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Phencyclidine
Methamphetamine
Frontal Lobe
Methoxydimethyltryptamines
Spiperone
Ketanserin
Synaptic Membranes
Apomorphine
Nucleus Accumbens
Dopamine
Serotonin
Head
Incidence
Brain

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)

Cite this

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abstract = "We investigated whether effects of phencyclidine (PCP) were modified by repeated pretreatment with methamphetamine (MAP) at a high (15mg/kg/day for 4 days) dose in rats. The incidence of turning, head-weaving and backpedalling induced by PCP was increased by pretreatment with MAP. In the rats pre-treated with MAP, 1) behavioral responses induced by acute MAP, apomorphine and 5-methoxy-N,N-dimethyltryptamine were potentiated; 2) dopamine content in the striatum, nucleus accumbens and frontal cortex and serotonin content in the striatum and frontal cortex were decreased; and 3) the Bmax and Kd values for [3H]-spiperone and [3H]-ketanserin bindings to brain synaptic membrane were significantly increased. These results suggest that 4 days-repeated administration of MAP (15 mg/kg) increases postsynaptic activity of both dopaminergic and serotonergic neuronal systems, and that there may be cross sensitization to PCP in the dopaminergic neuronal function following repeated administration of MAP at high dose.",
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Cross sensitization between phencyclidine and methamphetamine : II repeated administration of methamphetamine at a high dose. / Nabeshima, Toshitaka; Fukaya, H.; Kamei, H.; Ishikawa, K.; Furukawa, H.; Kameyama, T.

In: Research Communications in Substances of Abuse, Vol. 10, No. 2, 01.01.1989, p. 95-107.

Research output: Contribution to journalArticle

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