Cruciform DNA

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Cruciform DNA is a secondary structure on a helical double-stranded DNA molecule that comprises a four-way junction and two closed hairpin-shaped points. Double-stranded inverted repeats or DNA palindromes have the potential to form cruciform structures by intrastrand base pairing to extrude a pair of stem-loop structures under conditions of negative superhelicity. The junction of the cruciform is equivalent to a Holliday junction, which is a homologous recombination intermediate that is crucial for the maintenance of genomic integrity. Hence, cruciform DNA structures are recognized by several structure-specific enzymes, such as Holliday junction resolvases. Although cruciform formation in vivo remains to be validated, it is speculated that the formation of these unusual structures may fulfill a vital biological role or possibly induce genomic instabilities leading to deletions or chromosomal translocations.

Original languageEnglish
Title of host publicationBrenner's Encyclopedia of Genetics
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages241-243
Number of pages3
ISBN (Electronic)9780080961569
ISBN (Print)9780123749840
DOIs
Publication statusPublished - 27-02-2013

Fingerprint

Cruciform DNA
Holliday Junction Resolvases
DNA
Genetic Translocation
Genomic Instability
Homologous Recombination
genomics
Base Pairing
homologous recombination
Maintenance
Enzymes
Molecules
stems
enzymes

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Inagaki, H., & Kurahashi, H. (2013). Cruciform DNA. In Brenner's Encyclopedia of Genetics: Second Edition (pp. 241-243). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-374984-0.00361-2
Inagaki, Hidehito ; Kurahashi, Hiroki. / Cruciform DNA. Brenner's Encyclopedia of Genetics: Second Edition. Elsevier Inc., 2013. pp. 241-243
@inbook{6e42978eda9c4daaa54525e19a9017ee,
title = "Cruciform DNA",
abstract = "Cruciform DNA is a secondary structure on a helical double-stranded DNA molecule that comprises a four-way junction and two closed hairpin-shaped points. Double-stranded inverted repeats or DNA palindromes have the potential to form cruciform structures by intrastrand base pairing to extrude a pair of stem-loop structures under conditions of negative superhelicity. The junction of the cruciform is equivalent to a Holliday junction, which is a homologous recombination intermediate that is crucial for the maintenance of genomic integrity. Hence, cruciform DNA structures are recognized by several structure-specific enzymes, such as Holliday junction resolvases. Although cruciform formation in vivo remains to be validated, it is speculated that the formation of these unusual structures may fulfill a vital biological role or possibly induce genomic instabilities leading to deletions or chromosomal translocations.",
author = "Hidehito Inagaki and Hiroki Kurahashi",
year = "2013",
month = "2",
day = "27",
doi = "10.1016/B978-0-12-374984-0.00361-2",
language = "English",
isbn = "9780123749840",
pages = "241--243",
booktitle = "Brenner's Encyclopedia of Genetics",
publisher = "Elsevier Inc.",
address = "United States",

}

Inagaki, H & Kurahashi, H 2013, Cruciform DNA. in Brenner's Encyclopedia of Genetics: Second Edition. Elsevier Inc., pp. 241-243. https://doi.org/10.1016/B978-0-12-374984-0.00361-2

Cruciform DNA. / Inagaki, Hidehito; Kurahashi, Hiroki.

Brenner's Encyclopedia of Genetics: Second Edition. Elsevier Inc., 2013. p. 241-243.

Research output: Chapter in Book/Report/Conference proceedingChapter

TY - CHAP

T1 - Cruciform DNA

AU - Inagaki, Hidehito

AU - Kurahashi, Hiroki

PY - 2013/2/27

Y1 - 2013/2/27

N2 - Cruciform DNA is a secondary structure on a helical double-stranded DNA molecule that comprises a four-way junction and two closed hairpin-shaped points. Double-stranded inverted repeats or DNA palindromes have the potential to form cruciform structures by intrastrand base pairing to extrude a pair of stem-loop structures under conditions of negative superhelicity. The junction of the cruciform is equivalent to a Holliday junction, which is a homologous recombination intermediate that is crucial for the maintenance of genomic integrity. Hence, cruciform DNA structures are recognized by several structure-specific enzymes, such as Holliday junction resolvases. Although cruciform formation in vivo remains to be validated, it is speculated that the formation of these unusual structures may fulfill a vital biological role or possibly induce genomic instabilities leading to deletions or chromosomal translocations.

AB - Cruciform DNA is a secondary structure on a helical double-stranded DNA molecule that comprises a four-way junction and two closed hairpin-shaped points. Double-stranded inverted repeats or DNA palindromes have the potential to form cruciform structures by intrastrand base pairing to extrude a pair of stem-loop structures under conditions of negative superhelicity. The junction of the cruciform is equivalent to a Holliday junction, which is a homologous recombination intermediate that is crucial for the maintenance of genomic integrity. Hence, cruciform DNA structures are recognized by several structure-specific enzymes, such as Holliday junction resolvases. Although cruciform formation in vivo remains to be validated, it is speculated that the formation of these unusual structures may fulfill a vital biological role or possibly induce genomic instabilities leading to deletions or chromosomal translocations.

UR - http://www.scopus.com/inward/record.url?scp=84983327026&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84983327026&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-374984-0.00361-2

DO - 10.1016/B978-0-12-374984-0.00361-2

M3 - Chapter

SN - 9780123749840

SP - 241

EP - 243

BT - Brenner's Encyclopedia of Genetics

PB - Elsevier Inc.

ER -

Inagaki H, Kurahashi H. Cruciform DNA. In Brenner's Encyclopedia of Genetics: Second Edition. Elsevier Inc. 2013. p. 241-243 https://doi.org/10.1016/B978-0-12-374984-0.00361-2