TY - JOUR
T1 - Cushing's syndrome due to ovarian serous adenocarcinoma secreting multiple endocrine substances
T2 - a case report and immunohistochemical analysis.
AU - Suzuki, Takahiro
AU - Ino, Kazuhiko
AU - Kikkawa, Fumitaka
AU - Shibata, Kiyosumi
AU - Kajiyama, Hiroaki
AU - Morita, Takanori
AU - Nagasaka, Tetsuro
AU - Mizutani, Shigehiko
N1 - Copyright:
This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
PY - 2003
Y1 - 2003
N2 - BACKGROUND: Although Cushing's syndrome arises from various neuroendocrine tumors secreting adrenocorticotropin (ACTH) ectopically, ovarian carcinoma rarely causes this syndrome. CASE: A 66-year-old woman presented with facial swelling and skin pigmentation. She manifested hypercortisolemia, high plasma ACTH, and lack of dexamethasone suppression. MRI showed a solid ovarian tumor and resection of the tumor led to normalization of ACTH and cortisol levels. In addition, elevated serum vasopressin (ADH) and alpha-fetoprotein (AFP) were found, which were also normalized after removal of tumors. Pathological diagnosis was serous adenocarcinoma with neuroendocrine and hepatoid features. Immunohistochemistry detected immunoreactivity of chromogranin A, ACTH, ADH, and AFP in tumor cells. CONCLUSION: This is a very rare case of successful treatment of Cushing's syndrome arising from an ovarian adenocarcinoma secreting multiple endocrine substances.
AB - BACKGROUND: Although Cushing's syndrome arises from various neuroendocrine tumors secreting adrenocorticotropin (ACTH) ectopically, ovarian carcinoma rarely causes this syndrome. CASE: A 66-year-old woman presented with facial swelling and skin pigmentation. She manifested hypercortisolemia, high plasma ACTH, and lack of dexamethasone suppression. MRI showed a solid ovarian tumor and resection of the tumor led to normalization of ACTH and cortisol levels. In addition, elevated serum vasopressin (ADH) and alpha-fetoprotein (AFP) were found, which were also normalized after removal of tumors. Pathological diagnosis was serous adenocarcinoma with neuroendocrine and hepatoid features. Immunohistochemistry detected immunoreactivity of chromogranin A, ACTH, ADH, and AFP in tumor cells. CONCLUSION: This is a very rare case of successful treatment of Cushing's syndrome arising from an ovarian adenocarcinoma secreting multiple endocrine substances.
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U2 - 10.1016/S0090-8258(03)00407-4
DO - 10.1016/S0090-8258(03)00407-4
M3 - Article
C2 - 13678742
AN - SCOPUS:0141940292
SN - 0090-8258
VL - 90
SP - 662
EP - 666
JO - Gynecologic oncology
JF - Gynecologic oncology
IS - 3
ER -