Cyclin D1 overexpression in N-methyl-N′-nitro-N-nitrosoguanidine-induced rat gastric adenocarcinomas

Shinji Takasu, Tetsuya Tsukamoto, Toshikazu Ushijima, Satoshi Yamashita, Naotaka Ogasawara, Hisayo Ban, Tokuma Yanai, Toshiaki Masegi, Masae Tatematsu

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Changes in cell cycle regulation are involved in many human cancers, including gastric cancer. In the present study, cyclin D1 expression and localization were immunohistochemically analyzed in 23 N-methyl-N′-nitro-N-nitrosoguanidine-induced rat gastric adenocarcinomas and compared with findings for β-catenin. Cyclin D1 nuclear overexpression was more frequently observed in tumors displaying nuclear (4/4=100%) and cytoplasmic (3/4=75%) β-catenin accumulation than those with membranous (3/15=20%) localization (nuclear vs. membranous, P<0.02). In the former cases it was considered that cyclin D1 was induced with β-catenin activation; in the latter, a direct or indirect pathway for cyclin D1 accumulation bypassing Wnt pathway might be involved. Cyclin D1 was also found to be accumulated in gastric glands within normal-looking mucosa, these perhaps representing preneoplastic lesions for cancers with membranous β-catenin accumulation.

Original languageEnglish
Pages (from-to)171-175
Number of pages5
JournalExperimental and Toxicologic Pathology
Issue number3-4
Publication statusPublished - 26-11-2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Toxicology
  • Cell Biology


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