Cyclin D1 overexpression in N-methyl-N′-nitro-N-nitrosoguanidine-induced rat gastric adenocarcinomas

Shinji Takasu; Tetsuya Tsukamoto; Toshikazu Ushijima; Satoshi Yamashita; Naotaka Ogasawara; Hisayo Ban; Tokuma Yanai; Toshiaki Masegi; Masae Tatematsu

doi:10.1016/j.etp.2007.06.005

Cyclin D1 overexpression in N-methyl-N′-nitro-N-nitrosoguanidine-induced rat gastric adenocarcinomas

Shinji Takasu
, Tetsuya Tsukamoto
, Toshikazu Ushijima
, Satoshi Yamashita
, Naotaka Ogasawara
, Hisayo Ban
, Tokuma Yanai
, Toshiaki Masegi
, Masae Tatematsu

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Changes in cell cycle regulation are involved in many human cancers, including gastric cancer. In the present study, cyclin D1 expression and localization were immunohistochemically analyzed in 23 N-methyl-N′-nitro-N-nitrosoguanidine-induced rat gastric adenocarcinomas and compared with findings for β-catenin. Cyclin D1 nuclear overexpression was more frequently observed in tumors displaying nuclear (4/4=100%) and cytoplasmic (3/4=75%) β-catenin accumulation than those with membranous (3/15=20%) localization (nuclear vs. membranous, P<0.02). In the former cases it was considered that cyclin D1 was induced with β-catenin activation; in the latter, a direct or indirect pathway for cyclin D1 accumulation bypassing Wnt pathway might be involved. Cyclin D1 was also found to be accumulated in gastric glands within normal-looking mucosa, these perhaps representing preneoplastic lesions for cancers with membranous β-catenin accumulation.

Original language	English
Pages (from-to)	171-175
Number of pages	5
Journal	Experimental and Toxicologic Pathology
Volume	59
Issue number	3-4
DOIs	https://doi.org/10.1016/j.etp.2007.06.005
Publication status	Published - 26-11-2007
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Pathology and Forensic Medicine
Toxicology
Cell Biology

Access to Document

10.1016/j.etp.2007.06.005

Cite this

@article{f93c2d7b18884b9cad1ab0e764420524,

title = "Cyclin D1 overexpression in N-methyl-N′-nitro-N-nitrosoguanidine-induced rat gastric adenocarcinomas",

abstract = "Changes in cell cycle regulation are involved in many human cancers, including gastric cancer. In the present study, cyclin D1 expression and localization were immunohistochemically analyzed in 23 N-methyl-N′-nitro-N-nitrosoguanidine-induced rat gastric adenocarcinomas and compared with findings for β-catenin. Cyclin D1 nuclear overexpression was more frequently observed in tumors displaying nuclear (4/4=100\%) and cytoplasmic (3/4=75\%) β-catenin accumulation than those with membranous (3/15=20\%) localization (nuclear vs. membranous, P<0.02). In the former cases it was considered that cyclin D1 was induced with β-catenin activation; in the latter, a direct or indirect pathway for cyclin D1 accumulation bypassing Wnt pathway might be involved. Cyclin D1 was also found to be accumulated in gastric glands within normal-looking mucosa, these perhaps representing preneoplastic lesions for cancers with membranous β-catenin accumulation.",

author = "Shinji Takasu and Tetsuya Tsukamoto and Toshikazu Ushijima and Satoshi Yamashita and Naotaka Ogasawara and Hisayo Ban and Tokuma Yanai and Toshiaki Masegi and Masae Tatematsu",

note = "Funding Information: This work was supported in part by a Grant-in-Aid for Cancer Research from the Ministry of Health, Labour and Welfare of Japan and a Grant-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan.",

year = "2007",

month = nov,

day = "26",

doi = "10.1016/j.etp.2007.06.005",

language = "English",

volume = "59",

pages = "171--175",

journal = "Experimental and Toxicologic Pathology",

issn = "0940-2993",

publisher = "Urban und Fischer Verlag Jena",

number = "3-4",

}

TY - JOUR

T1 - Cyclin D1 overexpression in N-methyl-N′-nitro-N-nitrosoguanidine-induced rat gastric adenocarcinomas

AU - Takasu, Shinji

AU - Tsukamoto, Tetsuya

AU - Ushijima, Toshikazu

AU - Yamashita, Satoshi

AU - Ogasawara, Naotaka

AU - Ban, Hisayo

AU - Yanai, Tokuma

AU - Masegi, Toshiaki

AU - Tatematsu, Masae

N1 - Funding Information: This work was supported in part by a Grant-in-Aid for Cancer Research from the Ministry of Health, Labour and Welfare of Japan and a Grant-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan.

PY - 2007/11/26

Y1 - 2007/11/26

N2 - Changes in cell cycle regulation are involved in many human cancers, including gastric cancer. In the present study, cyclin D1 expression and localization were immunohistochemically analyzed in 23 N-methyl-N′-nitro-N-nitrosoguanidine-induced rat gastric adenocarcinomas and compared with findings for β-catenin. Cyclin D1 nuclear overexpression was more frequently observed in tumors displaying nuclear (4/4=100%) and cytoplasmic (3/4=75%) β-catenin accumulation than those with membranous (3/15=20%) localization (nuclear vs. membranous, P<0.02). In the former cases it was considered that cyclin D1 was induced with β-catenin activation; in the latter, a direct or indirect pathway for cyclin D1 accumulation bypassing Wnt pathway might be involved. Cyclin D1 was also found to be accumulated in gastric glands within normal-looking mucosa, these perhaps representing preneoplastic lesions for cancers with membranous β-catenin accumulation.

AB - Changes in cell cycle regulation are involved in many human cancers, including gastric cancer. In the present study, cyclin D1 expression and localization were immunohistochemically analyzed in 23 N-methyl-N′-nitro-N-nitrosoguanidine-induced rat gastric adenocarcinomas and compared with findings for β-catenin. Cyclin D1 nuclear overexpression was more frequently observed in tumors displaying nuclear (4/4=100%) and cytoplasmic (3/4=75%) β-catenin accumulation than those with membranous (3/15=20%) localization (nuclear vs. membranous, P<0.02). In the former cases it was considered that cyclin D1 was induced with β-catenin activation; in the latter, a direct or indirect pathway for cyclin D1 accumulation bypassing Wnt pathway might be involved. Cyclin D1 was also found to be accumulated in gastric glands within normal-looking mucosa, these perhaps representing preneoplastic lesions for cancers with membranous β-catenin accumulation.

UR - https://www.scopus.com/pages/publications/35648952139

UR - https://www.scopus.com/pages/publications/35648952139#tab=citedBy

U2 - 10.1016/j.etp.2007.06.005

DO - 10.1016/j.etp.2007.06.005

M3 - Article

C2 - 17855062

AN - SCOPUS:35648952139

SN - 0940-2993

VL - 59

SP - 171

EP - 175

JO - Experimental and Toxicologic Pathology

JF - Experimental and Toxicologic Pathology

IS - 3-4

ER -

Cyclin D1 overexpression in N-methyl-N′-nitro-N-nitrosoguanidine-induced rat gastric adenocarcinomas

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this