Cytohistology of morule in cribriform-morular variant of papillary thyroid carcinoma

Kouhei Sakurai, Takanori Onouchi, Seiji Yamada, Youichirou Baba, Tetsuya Murata, Tetsuya Tsukamoto, Makoto Kuroda, Makoto Urano

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Introduction: Cribriform-morular variant (CMV) is a rare variant of papillary thyroid carcinoma. It frequently occurs in association with familial adenomatous polyposis (FAP), although some cases are sporadic. Herein, we report a case of CMV and analyse morule cytohistology. Case Report: The patient was a 47-year-old woman with no familial history of FAP. A 3.0-cm unifocal mass was identified in the left thyroidal lobe. Fine-needle aspiration cytology revealed papillary clusters of atypical cells with nuclear grooves, which was suspected to be conventional papillary thyroid carcinoma. Histologically, the tumour comprised a papillary and cribriform growth of atypical cells with cytoplasmic accumulation and nuclear translocation of b-catenin. In addition, frequent morule formation was identified. Discussion: In this case, we performed morule analysis through correlative light and electron microscopy (CLEM), and revealed its ultrastructure. Although CMV is a rare form of thyroid carcinoma, it should be considered along with its distinct clinicopathological characteristics.

Original languageEnglish
Pages (from-to)339-343
Number of pages5
JournalMalaysian Journal of Pathology
Issue number3
Publication statusPublished - 2019

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology


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