Cytokine and chemokine responses in pediatric patients with severe pneumonia associated with pandemic A/H1N1/2009 influenza virus

Yuji Matsumoto, Yoshiki Kawamura, Hidetaka Nakai, Ken Sugata, Akiko Yoshikawa, Masaru Ihira, Masahiro Ohashi, Tomochika Kato, Tetsushi Yoshikawa

Research output: Contribution to journalArticle

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Abstract

Severe pneumonia and leukocytosis are characteristic, frequently observed, clinical findings in pediatric patients with pandemic A/H1N1/2009 influenza virus infection. The aim of this study was to elucidate the role of cytokines and chemokines in complicating pneumonia and leukocytosis in patients with pandemic A/H1N1/2009 influenza virus infection. Forty-seven patients with pandemic A/H1N1/2009 influenza virus infection were enrolled in this study. Expression of interleukin (IL)-10 (P=0.027) and IL-5 (P=0.014) was significantly greater in patients with pneumonia than in those without pneumonia. Additionally, serum concentrations of interferon-γ (P=0.009), tumor necrosis factor-α (P=0.01), IL-4 (P=0.024), and IL-2 (P=0.012) were significantly lower in pneumonia patients with neutrophilic leukocytosis than in those without neutrophilic leukocytosis. Of the five serum chemokine concentrations assessed, only IL-8 was significantly lower in pneumonia patients with neutrophilic leukocytosis than in those without leukocytosis (P=0.001). These cytokines and chemokines may play important roles in the pathogenesis of childhood pneumonia associated with A/H1N1/2009 influenza virus infection.

Original languageEnglish
Pages (from-to)651-655
Number of pages5
JournalMicrobiology and Immunology
Volume56
Issue number9
DOIs
Publication statusPublished - 01-09-2012

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Pandemics
Orthomyxoviridae
Chemokines
Leukocytosis
Pneumonia
Pediatrics
Cytokines
Virus Diseases
Interleukin-5
Serum
Interleukin-8
Interleukin-4
Interleukin-10
Interferons
Interleukin-2
Tumor Necrosis Factor-alpha

All Science Journal Classification (ASJC) codes

  • Immunology
  • Microbiology
  • Virology

Cite this

Matsumoto, Yuji ; Kawamura, Yoshiki ; Nakai, Hidetaka ; Sugata, Ken ; Yoshikawa, Akiko ; Ihira, Masaru ; Ohashi, Masahiro ; Kato, Tomochika ; Yoshikawa, Tetsushi. / Cytokine and chemokine responses in pediatric patients with severe pneumonia associated with pandemic A/H1N1/2009 influenza virus. In: Microbiology and Immunology. 2012 ; Vol. 56, No. 9. pp. 651-655.
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Cytokine and chemokine responses in pediatric patients with severe pneumonia associated with pandemic A/H1N1/2009 influenza virus. / Matsumoto, Yuji; Kawamura, Yoshiki; Nakai, Hidetaka; Sugata, Ken; Yoshikawa, Akiko; Ihira, Masaru; Ohashi, Masahiro; Kato, Tomochika; Yoshikawa, Tetsushi.

In: Microbiology and Immunology, Vol. 56, No. 9, 01.09.2012, p. 651-655.

Research output: Contribution to journalArticle

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