Cytokine and chemokine responses in the blood and cerebrospinal fluid of patients with human herpesvirus 6B-associated acute encephalopathy with biphasic seizures and late reduced diffusion

Yoshiki Kawamura, Yumie Yamazaki, Masahiro Ohashi, Masaru Ihira, Tetsushi Yoshikawa

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Abstract

Acute encephalopathy with biphasic seizures and late reduced diffusion has become increasingly common among various types of human herpesvirus 6B (HHV-6B) encephalitis at the time of primary viral infection. The aim of the present study is to explore the pathophysiology of HHV-6B-associated acute encephalopathy with biphasic seizures and late reduced diffusion. Five cytokines and five chemokines were measured in serum and cerebrospinal fluid (CSF) obtained from 12 HHV-6B-associated acute encephalopathy with biphasic seizures and late reduced diffusion patients and 19 control exanthem subitum (without complications) patients. Serum interleukin (IL)-10 (P=0.007) and IL-8 (P=0.025) were significantly higher in the patients with the disease than controls. Serum IL-1β (P=0.034) and monocyte chemoattractant protein (MCP)-1 (P=0.002) were significantly higher in the controls than patients with the disease. In patients with the disease, IL-10 (P=0.012), regulated on activation normal T cell expressed and secreted (RANTES; P=0.001), and monokine induced by interferon γ (MIG; P=0.001) were significantly higher in serum than CSF, meanwhile IL-6 (P=0.034), IL-8 (P=0.034), and MCP-1 (P=0.001) were significantly higher in CSF than serum. Additionally, serum IL-10 was significantly higher in the disease patients with sequelae than those without sequelae (P=0.016). Several cytokines and chemokines may be associated with the pathogenesis of acute encephalopathy with biphasic seizures and late reduced diffusion. Moreover, the regulation of cytokine networks appears to be different between peripheral blood (systemic) and central nervous system. J. Med. Virol. 86:512-518, 2014.

Original languageEnglish
Pages (from-to)512-518
Number of pages7
JournalJournal of Medical Virology
Volume86
Issue number3
DOIs
Publication statusPublished - 01-03-2014

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Human Herpesvirus 6
Brain Diseases
Chemokines
Cerebrospinal Fluid
Seizures
Cytokines
Serum
Interleukin-10
Chemokine CCL2
Interleukin-8
Monokines
Chemokine CCL5
Virus Diseases
Encephalitis
Exanthema
Interleukin-1
Interferons
Interleukin-6
Central Nervous System
T-Lymphocytes

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases

Cite this

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title = "Cytokine and chemokine responses in the blood and cerebrospinal fluid of patients with human herpesvirus 6B-associated acute encephalopathy with biphasic seizures and late reduced diffusion",
abstract = "Acute encephalopathy with biphasic seizures and late reduced diffusion has become increasingly common among various types of human herpesvirus 6B (HHV-6B) encephalitis at the time of primary viral infection. The aim of the present study is to explore the pathophysiology of HHV-6B-associated acute encephalopathy with biphasic seizures and late reduced diffusion. Five cytokines and five chemokines were measured in serum and cerebrospinal fluid (CSF) obtained from 12 HHV-6B-associated acute encephalopathy with biphasic seizures and late reduced diffusion patients and 19 control exanthem subitum (without complications) patients. Serum interleukin (IL)-10 (P=0.007) and IL-8 (P=0.025) were significantly higher in the patients with the disease than controls. Serum IL-1β (P=0.034) and monocyte chemoattractant protein (MCP)-1 (P=0.002) were significantly higher in the controls than patients with the disease. In patients with the disease, IL-10 (P=0.012), regulated on activation normal T cell expressed and secreted (RANTES; P=0.001), and monokine induced by interferon γ (MIG; P=0.001) were significantly higher in serum than CSF, meanwhile IL-6 (P=0.034), IL-8 (P=0.034), and MCP-1 (P=0.001) were significantly higher in CSF than serum. Additionally, serum IL-10 was significantly higher in the disease patients with sequelae than those without sequelae (P=0.016). Several cytokines and chemokines may be associated with the pathogenesis of acute encephalopathy with biphasic seizures and late reduced diffusion. Moreover, the regulation of cytokine networks appears to be different between peripheral blood (systemic) and central nervous system. J. Med. Virol. 86:512-518, 2014.",
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T1 - Cytokine and chemokine responses in the blood and cerebrospinal fluid of patients with human herpesvirus 6B-associated acute encephalopathy with biphasic seizures and late reduced diffusion

AU - Kawamura, Yoshiki

AU - Yamazaki, Yumie

AU - Ohashi, Masahiro

AU - Ihira, Masaru

AU - Yoshikawa, Tetsushi

PY - 2014/3/1

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N2 - Acute encephalopathy with biphasic seizures and late reduced diffusion has become increasingly common among various types of human herpesvirus 6B (HHV-6B) encephalitis at the time of primary viral infection. The aim of the present study is to explore the pathophysiology of HHV-6B-associated acute encephalopathy with biphasic seizures and late reduced diffusion. Five cytokines and five chemokines were measured in serum and cerebrospinal fluid (CSF) obtained from 12 HHV-6B-associated acute encephalopathy with biphasic seizures and late reduced diffusion patients and 19 control exanthem subitum (without complications) patients. Serum interleukin (IL)-10 (P=0.007) and IL-8 (P=0.025) were significantly higher in the patients with the disease than controls. Serum IL-1β (P=0.034) and monocyte chemoattractant protein (MCP)-1 (P=0.002) were significantly higher in the controls than patients with the disease. In patients with the disease, IL-10 (P=0.012), regulated on activation normal T cell expressed and secreted (RANTES; P=0.001), and monokine induced by interferon γ (MIG; P=0.001) were significantly higher in serum than CSF, meanwhile IL-6 (P=0.034), IL-8 (P=0.034), and MCP-1 (P=0.001) were significantly higher in CSF than serum. Additionally, serum IL-10 was significantly higher in the disease patients with sequelae than those without sequelae (P=0.016). Several cytokines and chemokines may be associated with the pathogenesis of acute encephalopathy with biphasic seizures and late reduced diffusion. Moreover, the regulation of cytokine networks appears to be different between peripheral blood (systemic) and central nervous system. J. Med. Virol. 86:512-518, 2014.

AB - Acute encephalopathy with biphasic seizures and late reduced diffusion has become increasingly common among various types of human herpesvirus 6B (HHV-6B) encephalitis at the time of primary viral infection. The aim of the present study is to explore the pathophysiology of HHV-6B-associated acute encephalopathy with biphasic seizures and late reduced diffusion. Five cytokines and five chemokines were measured in serum and cerebrospinal fluid (CSF) obtained from 12 HHV-6B-associated acute encephalopathy with biphasic seizures and late reduced diffusion patients and 19 control exanthem subitum (without complications) patients. Serum interleukin (IL)-10 (P=0.007) and IL-8 (P=0.025) were significantly higher in the patients with the disease than controls. Serum IL-1β (P=0.034) and monocyte chemoattractant protein (MCP)-1 (P=0.002) were significantly higher in the controls than patients with the disease. In patients with the disease, IL-10 (P=0.012), regulated on activation normal T cell expressed and secreted (RANTES; P=0.001), and monokine induced by interferon γ (MIG; P=0.001) were significantly higher in serum than CSF, meanwhile IL-6 (P=0.034), IL-8 (P=0.034), and MCP-1 (P=0.001) were significantly higher in CSF than serum. Additionally, serum IL-10 was significantly higher in the disease patients with sequelae than those without sequelae (P=0.016). Several cytokines and chemokines may be associated with the pathogenesis of acute encephalopathy with biphasic seizures and late reduced diffusion. Moreover, the regulation of cytokine networks appears to be different between peripheral blood (systemic) and central nervous system. J. Med. Virol. 86:512-518, 2014.

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