Cytokines and biological markers in autoimmune GFAP astrocytopathy: The potential role for pathogenesis and therapeutic implications

Akio Kimura, Masao Takemura, Yasuko Yamamoto, Yuichi Hayashi, Kuniaki Saito, Takayoshi Shimohata

Research output: Contribution to journalArticle

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Abstract

Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy (GFAP-A) is a corticosteroid-responsive meningoencephalomyelitis with a poorly understood pathogenesis. We examined and compared the levels of cytokines and biological markers in the cerebrospinal fluid (CSF) of patients with GFAP-A and other neurological disorders. We identified four cytokines (tumor necrosis factor alpha [TNFα], Interleukin [IL]-27, IL-6, and chemokine [C-C motif] ligand 20) and three biological markers (GFAP, S100 calcium-binding protein B, and neurofilament light chain) present at elevated levels in CSF samples during the acute phase of GFAP-A. Additionally, we identified significant correlations between CSF TNFα, IL-27, IL-6, and CSF biological markers.

Original languageEnglish
Article number576999
JournalJournal of Neuroimmunology
Volume334
DOIs
Publication statusPublished - 15-09-2019

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Glial Fibrillary Acidic Protein
Cerebrospinal Fluid
Biomarkers
Interleukin-27
Cytokines
Staphylococcal Protein A
Interleukin-6
Tumor Necrosis Factor-alpha
CC Chemokines
Calcium-Binding Proteins
Intermediate Filaments
Therapeutics
Nervous System Diseases
Adrenal Cortex Hormones
Ligands
Light

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Cite this

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abstract = "Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy (GFAP-A) is a corticosteroid-responsive meningoencephalomyelitis with a poorly understood pathogenesis. We examined and compared the levels of cytokines and biological markers in the cerebrospinal fluid (CSF) of patients with GFAP-A and other neurological disorders. We identified four cytokines (tumor necrosis factor alpha [TNFα], Interleukin [IL]-27, IL-6, and chemokine [C-C motif] ligand 20) and three biological markers (GFAP, S100 calcium-binding protein B, and neurofilament light chain) present at elevated levels in CSF samples during the acute phase of GFAP-A. Additionally, we identified significant correlations between CSF TNFα, IL-27, IL-6, and CSF biological markers.",
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Cytokines and biological markers in autoimmune GFAP astrocytopathy : The potential role for pathogenesis and therapeutic implications. / Kimura, Akio; Takemura, Masao; Yamamoto, Yasuko; Hayashi, Yuichi; Saito, Kuniaki; Shimohata, Takayoshi.

In: Journal of Neuroimmunology, Vol. 334, 576999, 15.09.2019.

Research output: Contribution to journalArticle

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AU - Kimura, Akio

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AU - Yamamoto, Yasuko

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AU - Saito, Kuniaki

AU - Shimohata, Takayoshi

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AB - Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy (GFAP-A) is a corticosteroid-responsive meningoencephalomyelitis with a poorly understood pathogenesis. We examined and compared the levels of cytokines and biological markers in the cerebrospinal fluid (CSF) of patients with GFAP-A and other neurological disorders. We identified four cytokines (tumor necrosis factor alpha [TNFα], Interleukin [IL]-27, IL-6, and chemokine [C-C motif] ligand 20) and three biological markers (GFAP, S100 calcium-binding protein B, and neurofilament light chain) present at elevated levels in CSF samples during the acute phase of GFAP-A. Additionally, we identified significant correlations between CSF TNFα, IL-27, IL-6, and CSF biological markers.

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