Cytokines and biological markers in autoimmune GFAP astrocytopathy: The potential role for pathogenesis and therapeutic implications

Akio Kimura; Masao Takemura; Yasuko Yamamoto; Yuichi Hayashi; Kuniaki Saito; Takayoshi Shimohata

doi:10.1016/j.jneuroim.2019.576999

Cytokines and biological markers in autoimmune GFAP astrocytopathy: The potential role for pathogenesis and therapeutic implications

Akio Kimura
, Masao Takemura
, Yasuko Yamamoto
, Yuichi Hayashi
, Kuniaki Saito
, Takayoshi Shimohata

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy (GFAP-A) is a corticosteroid-responsive meningoencephalomyelitis with a poorly understood pathogenesis. We examined and compared the levels of cytokines and biological markers in the cerebrospinal fluid (CSF) of patients with GFAP-A and other neurological disorders. We identified four cytokines (tumor necrosis factor alpha [TNFα], Interleukin [IL]-27, IL-6, and chemokine [C-C motif] ligand 20) and three biological markers (GFAP, S100 calcium-binding protein B, and neurofilament light chain) present at elevated levels in CSF samples during the acute phase of GFAP-A. Additionally, we identified significant correlations between CSF TNFα, IL-27, IL-6, and CSF biological markers.

Original language	English
Article number	576999
Journal	Journal of Neuroimmunology
Volume	334
DOIs	https://doi.org/10.1016/j.jneuroim.2019.576999
Publication status	Published - 15-09-2019
Externally published	Yes

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

Access to Document

10.1016/j.jneuroim.2019.576999

Cite this

@article{5a9445e0fd4a4895894c31294cd7b344,

title = "Cytokines and biological markers in autoimmune GFAP astrocytopathy: The potential role for pathogenesis and therapeutic implications",

abstract = "Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy (GFAP-A) is a corticosteroid-responsive meningoencephalomyelitis with a poorly understood pathogenesis. We examined and compared the levels of cytokines and biological markers in the cerebrospinal fluid (CSF) of patients with GFAP-A and other neurological disorders. We identified four cytokines (tumor necrosis factor alpha [TNFα], Interleukin [IL]-27, IL-6, and chemokine [C-C motif] ligand 20) and three biological markers (GFAP, S100 calcium-binding protein B, and neurofilament light chain) present at elevated levels in CSF samples during the acute phase of GFAP-A. Additionally, we identified significant correlations between CSF TNFα, IL-27, IL-6, and CSF biological markers.",

author = "Akio Kimura and Masao Takemura and Yasuko Yamamoto and Yuichi Hayashi and Kuniaki Saito and Takayoshi Shimohata",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier B.V.",

year = "2019",

month = sep,

day = "15",

doi = "10.1016/j.jneuroim.2019.576999",

language = "English",

volume = "334",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Cytokines and biological markers in autoimmune GFAP astrocytopathy

T2 - The potential role for pathogenesis and therapeutic implications

AU - Kimura, Akio

AU - Takemura, Masao

AU - Yamamoto, Yasuko

AU - Hayashi, Yuichi

AU - Saito, Kuniaki

AU - Shimohata, Takayoshi

PY - 2019/9/15

Y1 - 2019/9/15

N2 - Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy (GFAP-A) is a corticosteroid-responsive meningoencephalomyelitis with a poorly understood pathogenesis. We examined and compared the levels of cytokines and biological markers in the cerebrospinal fluid (CSF) of patients with GFAP-A and other neurological disorders. We identified four cytokines (tumor necrosis factor alpha [TNFα], Interleukin [IL]-27, IL-6, and chemokine [C-C motif] ligand 20) and three biological markers (GFAP, S100 calcium-binding protein B, and neurofilament light chain) present at elevated levels in CSF samples during the acute phase of GFAP-A. Additionally, we identified significant correlations between CSF TNFα, IL-27, IL-6, and CSF biological markers.

AB - Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy (GFAP-A) is a corticosteroid-responsive meningoencephalomyelitis with a poorly understood pathogenesis. We examined and compared the levels of cytokines and biological markers in the cerebrospinal fluid (CSF) of patients with GFAP-A and other neurological disorders. We identified four cytokines (tumor necrosis factor alpha [TNFα], Interleukin [IL]-27, IL-6, and chemokine [C-C motif] ligand 20) and three biological markers (GFAP, S100 calcium-binding protein B, and neurofilament light chain) present at elevated levels in CSF samples during the acute phase of GFAP-A. Additionally, we identified significant correlations between CSF TNFα, IL-27, IL-6, and CSF biological markers.

UR - https://www.scopus.com/pages/publications/85067884892

UR - https://www.scopus.com/pages/publications/85067884892#tab=citedBy

U2 - 10.1016/j.jneuroim.2019.576999

DO - 10.1016/j.jneuroim.2019.576999

M3 - Article

C2 - 31254929

AN - SCOPUS:85067884892

SN - 0165-5728

VL - 334

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

M1 - 576999

ER -

Cytokines and biological markers in autoimmune GFAP astrocytopathy: The potential role for pathogenesis and therapeutic implications

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this