Cytokines regulate c-Met expression in cultured astrocytes

Kenji Shimazaki, Kazunari Yoshida, Yuichi Hirose, Hisatsugu Ishimori, Makoto Katayama, Takeshi Kawase

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We investigated c-Met expression in cultured astrocytes and their regulation by cytokines. Immunocytochemistry revealed that c-Met was expressed in cultured astrocytes. Western blotting revealed that acidic and basic fibroblast growth factor (FGF) enhanced and hepatocyte growth factor (HGF) reduced c-Met expression. Reverse transcription-polymerase chain reaction revealed that FGFs and HGF enhanced c-met expression. These findings suggest that c-Met expressed in astrocytes may have important roles during the nervous system regeneration.

Original languageEnglish
Pages (from-to)105-110
Number of pages6
JournalBrain Research
Volume962
Issue number1-2
DOIs
Publication statusPublished - 07-02-2003

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Astrocytes
Hepatocyte Growth Factor
Cytokines
Fibroblast Growth Factor 1
Fibroblast Growth Factor 2
Nervous System
Reverse Transcription
Regeneration
Western Blotting
Immunohistochemistry
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Developmental Biology
  • Clinical Neurology

Cite this

Shimazaki, K., Yoshida, K., Hirose, Y., Ishimori, H., Katayama, M., & Kawase, T. (2003). Cytokines regulate c-Met expression in cultured astrocytes. Brain Research, 962(1-2), 105-110. https://doi.org/10.1016/S0006-8993(02)03975-6
Shimazaki, Kenji ; Yoshida, Kazunari ; Hirose, Yuichi ; Ishimori, Hisatsugu ; Katayama, Makoto ; Kawase, Takeshi. / Cytokines regulate c-Met expression in cultured astrocytes. In: Brain Research. 2003 ; Vol. 962, No. 1-2. pp. 105-110.
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Shimazaki, K, Yoshida, K, Hirose, Y, Ishimori, H, Katayama, M & Kawase, T 2003, 'Cytokines regulate c-Met expression in cultured astrocytes', Brain Research, vol. 962, no. 1-2, pp. 105-110. https://doi.org/10.1016/S0006-8993(02)03975-6

Cytokines regulate c-Met expression in cultured astrocytes. / Shimazaki, Kenji; Yoshida, Kazunari; Hirose, Yuichi; Ishimori, Hisatsugu; Katayama, Makoto; Kawase, Takeshi.

In: Brain Research, Vol. 962, No. 1-2, 07.02.2003, p. 105-110.

Research output: Contribution to journalArticle

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Shimazaki K, Yoshida K, Hirose Y, Ishimori H, Katayama M, Kawase T. Cytokines regulate c-Met expression in cultured astrocytes. Brain Research. 2003 Feb 7;962(1-2):105-110. https://doi.org/10.1016/S0006-8993(02)03975-6