TY - JOUR
T1 - Cytomegalovirus and Epstein-Barr virus coinfection in three toddlers with prolonged illnesses
AU - Ito, Yoshinori
AU - Shibata-Watanabe, Yukiko
AU - Kawada, Jun Ichi
AU - Maruyama, Koichi
AU - Yagasaki, Hiroshi
AU - Kojima, Seiji
AU - Kimura, Hiroshi
PY - 2009/8
Y1 - 2009/8
N2 - Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) usually cause primary and latent infections during childhood; thus, coinfection with these viruses occurs occasionally in children. However, its clinical impact has not been established, and may be underestimated. Three cases of coinfection involving these two viruses in toddlers are described: a 14-month-old male with infectious mononucleosis, an 18-month-old female with hemophagocytic lymphohistiocytosis, and a 13-month-old female with acute hepatitis. All three patients had prolonged illnesses. Serial serological testing and quantitation of viral DNA for CMV and EBV using peripheral blood from the patients suggested primary infections with both viruses. In all three cases, the viral load of EBV and CMV in the early stage of disease exceeded 6.4×103 and 8.8×102 copies/ml of whole blood, respectively, suggesting that the viruses were associated with the clinical condition. Recognizing that coinfection with these viruses may modulate the clinical course of disease is important.
AB - Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) usually cause primary and latent infections during childhood; thus, coinfection with these viruses occurs occasionally in children. However, its clinical impact has not been established, and may be underestimated. Three cases of coinfection involving these two viruses in toddlers are described: a 14-month-old male with infectious mononucleosis, an 18-month-old female with hemophagocytic lymphohistiocytosis, and a 13-month-old female with acute hepatitis. All three patients had prolonged illnesses. Serial serological testing and quantitation of viral DNA for CMV and EBV using peripheral blood from the patients suggested primary infections with both viruses. In all three cases, the viral load of EBV and CMV in the early stage of disease exceeded 6.4×103 and 8.8×102 copies/ml of whole blood, respectively, suggesting that the viruses were associated with the clinical condition. Recognizing that coinfection with these viruses may modulate the clinical course of disease is important.
UR - http://www.scopus.com/inward/record.url?scp=68049115585&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=68049115585&partnerID=8YFLogxK
U2 - 10.1002/jmv.21527
DO - 10.1002/jmv.21527
M3 - Article
C2 - 19551835
AN - SCOPUS:68049115585
SN - 0146-6615
VL - 81
SP - 1399
EP - 1402
JO - Journal of Medical Virology
JF - Journal of Medical Virology
IS - 8
ER -