Dapsone-induced agranulocytosis leading to perianal abscess and death: A case report

Yoshiro Kobe, Daisuke Setoguchi, Nobuya Kitamura

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Introduction. Dapsone (diaminodiphenylsulfone) is used for the treatment of intractable skin diseases such as pemphigus and leprosy. The side effects of Dapsone are anemia, leukopenia, and liver dysfunction. Here, we present a case of agranulocytosis-induced septic shock, which was a side effect of Dapsone. Case presentation. An 82-year-old Japanese woman was transferred to our hospital with fever, leucopenia, and respiratory arrest. At the previous hospital, she had been administered Dapsone for linear IgA bullous dermatosis. At the time of admission, she presented with methemoglobinemia and septic shock, which was due to immunosuppression caused by the normal dose of Dapsone. Although her overall health initially improved, her condition deteriorated because of septic shock caused by an anal fistula. She died of sepsis on hospital day 80. Conclusion: One of the side effects of Dapsone is agranulocytosis. Patients with agranulocytosis may be in danger of developing anal fistula. Therefore, care must be taken if a patient with agranulocytosis develops a decubitus ulcer in the sacral region, since it could develop into a fistula-in-ano.

Original languageEnglish
Article number107
JournalJournal of Medical Case Reports
Publication statusPublished - 2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Medicine


Dive into the research topics of 'Dapsone-induced agranulocytosis leading to perianal abscess and death: A case report'. Together they form a unique fingerprint.

Cite this