Abstract
Objectives: Controlled artificial daylight exposure, such as light therapy, is effective in bipolar depression, but the association between uncontrolled daytime light and depressive symptoms in bipolar disorder (BD) is unclear. This study investigated the association between daytime light exposure under real-life situations and depressive symptom in patients with BD. Methods: This cross-sectional study enrolled 181 outpatients with BD. The average daytime light intensity and the total duration of light intensity of ≥1000 lux were recorded over 7 consecutive days using an actigraph that measured ambient light. Depressive symptoms were assessed using Montgomery–Åsberg Depression Rating Scale, and scores of ≥8 points were treated as depressed state. Results: Ninety-seven (53.6%) subjects were depressed state. At higher average daytime light intensity tertiles, the proportion of depressed state was significantly lower (P for trend, 0.003). In multivariable analysis adjusted for age, employment status, age at onset of BD, Young Mania Rating Scale score, bedtime, and physical activity, the highest tertile group in average daytime light intensity suggested a significantly lower odds ratio (OR) for depressed state than the lowest tertile group (OR, 0.33; 95% confidence interval [CI], 0.14–0.75; P = 0.009). Similarly, the longest tertile group in light intensity ≥1000 lux duration was significantly associated with lower OR for depressed state than lowest tertile group (OR, 0.42; 95% CI, 0.18–0.93; P = 0.033). Conclusions: The findings suggest that greater daytime light exposure in daily life is associated with decreased depressive symptoms in BD.
| Original language | English |
|---|---|
| Pages (from-to) | 151-156 |
| Number of pages | 6 |
| Journal | Journal of Psychiatric Research |
| Volume | 116 |
| DOIs | |
| Publication status | Published - 01-09-2019 |
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All Science Journal Classification (ASJC) codes
- Psychiatry and Mental health
- Biological Psychiatry
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Daytime light exposure in daily life and depressive symptoms in bipolar disorder : A cross-sectional analysis in the APPLE cohort. / Esaki, Yuichi; Kitajima, Tsuyoshi; Obayashi, Kenji; Saeki, Keigo; Fujita, Kiyoshi; Iwata, Nakao.
In: Journal of Psychiatric Research, Vol. 116, 01.09.2019, p. 151-156.Research output: Contribution to journal › Article
TY - JOUR
T1 - Daytime light exposure in daily life and depressive symptoms in bipolar disorder
T2 - A cross-sectional analysis in the APPLE cohort
AU - Esaki, Yuichi
AU - Kitajima, Tsuyoshi
AU - Obayashi, Kenji
AU - Saeki, Keigo
AU - Fujita, Kiyoshi
AU - Iwata, Nakao
PY - 2019/9/1
Y1 - 2019/9/1
N2 - Objectives: Controlled artificial daylight exposure, such as light therapy, is effective in bipolar depression, but the association between uncontrolled daytime light and depressive symptoms in bipolar disorder (BD) is unclear. This study investigated the association between daytime light exposure under real-life situations and depressive symptom in patients with BD. Methods: This cross-sectional study enrolled 181 outpatients with BD. The average daytime light intensity and the total duration of light intensity of ≥1000 lux were recorded over 7 consecutive days using an actigraph that measured ambient light. Depressive symptoms were assessed using Montgomery–Åsberg Depression Rating Scale, and scores of ≥8 points were treated as depressed state. Results: Ninety-seven (53.6%) subjects were depressed state. At higher average daytime light intensity tertiles, the proportion of depressed state was significantly lower (P for trend, 0.003). In multivariable analysis adjusted for age, employment status, age at onset of BD, Young Mania Rating Scale score, bedtime, and physical activity, the highest tertile group in average daytime light intensity suggested a significantly lower odds ratio (OR) for depressed state than the lowest tertile group (OR, 0.33; 95% confidence interval [CI], 0.14–0.75; P = 0.009). Similarly, the longest tertile group in light intensity ≥1000 lux duration was significantly associated with lower OR for depressed state than lowest tertile group (OR, 0.42; 95% CI, 0.18–0.93; P = 0.033). Conclusions: The findings suggest that greater daytime light exposure in daily life is associated with decreased depressive symptoms in BD.
AB - Objectives: Controlled artificial daylight exposure, such as light therapy, is effective in bipolar depression, but the association between uncontrolled daytime light and depressive symptoms in bipolar disorder (BD) is unclear. This study investigated the association between daytime light exposure under real-life situations and depressive symptom in patients with BD. Methods: This cross-sectional study enrolled 181 outpatients with BD. The average daytime light intensity and the total duration of light intensity of ≥1000 lux were recorded over 7 consecutive days using an actigraph that measured ambient light. Depressive symptoms were assessed using Montgomery–Åsberg Depression Rating Scale, and scores of ≥8 points were treated as depressed state. Results: Ninety-seven (53.6%) subjects were depressed state. At higher average daytime light intensity tertiles, the proportion of depressed state was significantly lower (P for trend, 0.003). In multivariable analysis adjusted for age, employment status, age at onset of BD, Young Mania Rating Scale score, bedtime, and physical activity, the highest tertile group in average daytime light intensity suggested a significantly lower odds ratio (OR) for depressed state than the lowest tertile group (OR, 0.33; 95% confidence interval [CI], 0.14–0.75; P = 0.009). Similarly, the longest tertile group in light intensity ≥1000 lux duration was significantly associated with lower OR for depressed state than lowest tertile group (OR, 0.42; 95% CI, 0.18–0.93; P = 0.033). Conclusions: The findings suggest that greater daytime light exposure in daily life is associated with decreased depressive symptoms in BD.
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U2 - 10.1016/j.jpsychires.2019.06.010
DO - 10.1016/j.jpsychires.2019.06.010
M3 - Article
C2 - 31247358
AN - SCOPUS:85067627155
VL - 116
SP - 151
EP - 156
JO - Journal of Psychiatric Research
JF - Journal of Psychiatric Research
SN - 0022-3956
ER -