DCD for islet transplantation

Takashi Kenmochi, Takehide Asano, Naotake Akutsu, Taihei Ito

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Pancreatic islet transplantation has the potential to become the most physiologically advantageous and minimally invasive procedure for the treatment of type 1 diabetes mellitus. Since the first clinical islet transplantation was performed at the University of Minnesota in 1974 [1], the results have been far from ideal for more than two decades in spite of an improvement of islet isolation technique by Ricordi et al. [2-4]. The introduction of the Edmonton protocol, with a highly improved rate of insulin independency, encouraged us to promote clinical islet transplantation [5, 6]. In Japan, we organized the Working Group (The Japanese Islet Transplant Registry) in 1997 under the Japanese Society for Pancreas and Islet Transplantation for the purpose of starting clinical islet transplantation. The first issue of the Working Group was to construct a system of clinical islet transplantation in Japan including the registration of the recipients, procurement of the pancreas for islet isolation and transplantation of the isolated islets. In Japan, afterwards, various problems facing to a start of clinical islet transplantation have been discussed and we completed the guideline for clinical islet transplantation in Japan. The Japanese Organ Transplant Law was enforced in 1997 and organ transplantations using brain dead (DBD) donors were finally started. Since the islet transplantation was not included in the Japanese Organ Transplant Law because it was categorized as tissue transplantation, we were able to use the pancreas only from DCD donors for islet transplantation. The first islet isolation from the human pancreas was performed in 2003.9 and the first islet transplantation was performed in 2004.4 [7-9]. Sixty-five islet isolations and 34 islet transplantations were performed in our country from 2003.9.12 to 2007.3.11 [10]. In this chapter, we describe the current status of clinical islet transplantation using DCD donors in Japan.

Original languageEnglish
Title of host publicationMarginal Donors
Subtitle of host publicationCurrent and Future Status
PublisherSpringer Japan
Pages237-248
Number of pages12
Volume9784431544845
ISBN (Electronic)9784431544845
ISBN (Print)4431544836, 9784431544838
DOIs
Publication statusPublished - 01-12-2014

Fingerprint

Islets of Langerhans Transplantation
Japan
Pancreas
dicarboxydine
Transplants
Tissue Transplantation
Pancreas Transplantation
Brain Death
Organ Transplantation
Type 1 Diabetes Mellitus

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Kenmochi, T., Asano, T., Akutsu, N., & Ito, T. (2014). DCD for islet transplantation. In Marginal Donors: Current and Future Status (Vol. 9784431544845, pp. 237-248). Springer Japan. https://doi.org/10.1007/978-4-431-54484-5_21
Kenmochi, Takashi ; Asano, Takehide ; Akutsu, Naotake ; Ito, Taihei. / DCD for islet transplantation. Marginal Donors: Current and Future Status. Vol. 9784431544845 Springer Japan, 2014. pp. 237-248
@inbook{9f20665c516b41c4907bad9a9bec17a2,
title = "DCD for islet transplantation",
abstract = "Pancreatic islet transplantation has the potential to become the most physiologically advantageous and minimally invasive procedure for the treatment of type 1 diabetes mellitus. Since the first clinical islet transplantation was performed at the University of Minnesota in 1974 [1], the results have been far from ideal for more than two decades in spite of an improvement of islet isolation technique by Ricordi et al. [2-4]. The introduction of the Edmonton protocol, with a highly improved rate of insulin independency, encouraged us to promote clinical islet transplantation [5, 6]. In Japan, we organized the Working Group (The Japanese Islet Transplant Registry) in 1997 under the Japanese Society for Pancreas and Islet Transplantation for the purpose of starting clinical islet transplantation. The first issue of the Working Group was to construct a system of clinical islet transplantation in Japan including the registration of the recipients, procurement of the pancreas for islet isolation and transplantation of the isolated islets. In Japan, afterwards, various problems facing to a start of clinical islet transplantation have been discussed and we completed the guideline for clinical islet transplantation in Japan. The Japanese Organ Transplant Law was enforced in 1997 and organ transplantations using brain dead (DBD) donors were finally started. Since the islet transplantation was not included in the Japanese Organ Transplant Law because it was categorized as tissue transplantation, we were able to use the pancreas only from DCD donors for islet transplantation. The first islet isolation from the human pancreas was performed in 2003.9 and the first islet transplantation was performed in 2004.4 [7-9]. Sixty-five islet isolations and 34 islet transplantations were performed in our country from 2003.9.12 to 2007.3.11 [10]. In this chapter, we describe the current status of clinical islet transplantation using DCD donors in Japan.",
author = "Takashi Kenmochi and Takehide Asano and Naotake Akutsu and Taihei Ito",
year = "2014",
month = "12",
day = "1",
doi = "10.1007/978-4-431-54484-5_21",
language = "English",
isbn = "4431544836",
volume = "9784431544845",
pages = "237--248",
booktitle = "Marginal Donors",
publisher = "Springer Japan",
address = "Japan",

}

Kenmochi, T, Asano, T, Akutsu, N & Ito, T 2014, DCD for islet transplantation. in Marginal Donors: Current and Future Status. vol. 9784431544845, Springer Japan, pp. 237-248. https://doi.org/10.1007/978-4-431-54484-5_21

DCD for islet transplantation. / Kenmochi, Takashi; Asano, Takehide; Akutsu, Naotake; Ito, Taihei.

Marginal Donors: Current and Future Status. Vol. 9784431544845 Springer Japan, 2014. p. 237-248.

Research output: Chapter in Book/Report/Conference proceedingChapter

TY - CHAP

T1 - DCD for islet transplantation

AU - Kenmochi, Takashi

AU - Asano, Takehide

AU - Akutsu, Naotake

AU - Ito, Taihei

PY - 2014/12/1

Y1 - 2014/12/1

N2 - Pancreatic islet transplantation has the potential to become the most physiologically advantageous and minimally invasive procedure for the treatment of type 1 diabetes mellitus. Since the first clinical islet transplantation was performed at the University of Minnesota in 1974 [1], the results have been far from ideal for more than two decades in spite of an improvement of islet isolation technique by Ricordi et al. [2-4]. The introduction of the Edmonton protocol, with a highly improved rate of insulin independency, encouraged us to promote clinical islet transplantation [5, 6]. In Japan, we organized the Working Group (The Japanese Islet Transplant Registry) in 1997 under the Japanese Society for Pancreas and Islet Transplantation for the purpose of starting clinical islet transplantation. The first issue of the Working Group was to construct a system of clinical islet transplantation in Japan including the registration of the recipients, procurement of the pancreas for islet isolation and transplantation of the isolated islets. In Japan, afterwards, various problems facing to a start of clinical islet transplantation have been discussed and we completed the guideline for clinical islet transplantation in Japan. The Japanese Organ Transplant Law was enforced in 1997 and organ transplantations using brain dead (DBD) donors were finally started. Since the islet transplantation was not included in the Japanese Organ Transplant Law because it was categorized as tissue transplantation, we were able to use the pancreas only from DCD donors for islet transplantation. The first islet isolation from the human pancreas was performed in 2003.9 and the first islet transplantation was performed in 2004.4 [7-9]. Sixty-five islet isolations and 34 islet transplantations were performed in our country from 2003.9.12 to 2007.3.11 [10]. In this chapter, we describe the current status of clinical islet transplantation using DCD donors in Japan.

AB - Pancreatic islet transplantation has the potential to become the most physiologically advantageous and minimally invasive procedure for the treatment of type 1 diabetes mellitus. Since the first clinical islet transplantation was performed at the University of Minnesota in 1974 [1], the results have been far from ideal for more than two decades in spite of an improvement of islet isolation technique by Ricordi et al. [2-4]. The introduction of the Edmonton protocol, with a highly improved rate of insulin independency, encouraged us to promote clinical islet transplantation [5, 6]. In Japan, we organized the Working Group (The Japanese Islet Transplant Registry) in 1997 under the Japanese Society for Pancreas and Islet Transplantation for the purpose of starting clinical islet transplantation. The first issue of the Working Group was to construct a system of clinical islet transplantation in Japan including the registration of the recipients, procurement of the pancreas for islet isolation and transplantation of the isolated islets. In Japan, afterwards, various problems facing to a start of clinical islet transplantation have been discussed and we completed the guideline for clinical islet transplantation in Japan. The Japanese Organ Transplant Law was enforced in 1997 and organ transplantations using brain dead (DBD) donors were finally started. Since the islet transplantation was not included in the Japanese Organ Transplant Law because it was categorized as tissue transplantation, we were able to use the pancreas only from DCD donors for islet transplantation. The first islet isolation from the human pancreas was performed in 2003.9 and the first islet transplantation was performed in 2004.4 [7-9]. Sixty-five islet isolations and 34 islet transplantations were performed in our country from 2003.9.12 to 2007.3.11 [10]. In this chapter, we describe the current status of clinical islet transplantation using DCD donors in Japan.

UR - http://www.scopus.com/inward/record.url?scp=84930732604&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930732604&partnerID=8YFLogxK

U2 - 10.1007/978-4-431-54484-5_21

DO - 10.1007/978-4-431-54484-5_21

M3 - Chapter

AN - SCOPUS:84930732604

SN - 4431544836

SN - 9784431544838

VL - 9784431544845

SP - 237

EP - 248

BT - Marginal Donors

PB - Springer Japan

ER -

Kenmochi T, Asano T, Akutsu N, Ito T. DCD for islet transplantation. In Marginal Donors: Current and Future Status. Vol. 9784431544845. Springer Japan. 2014. p. 237-248 https://doi.org/10.1007/978-4-431-54484-5_21