Decline of plasma concentrations of interleukin-18 in severely malnourished patients with anorexia nervosa

Exploratory analysis

Satoshi Tanaka, Tomoko Oya-Ito, Yuki Murakami, Kuniaki Saito, Sho Furuta, Yanjie Yu, Miho Imaeda, Shohko Kunimoto, Norio Ozaki

Research output: Contribution to journalArticle

Abstract

Multiple studies on the dynamics of inflammatory cytokines in patients with anorexia nervosa (AN) have been published, although results are not consistent among reports. Thus the pathophysiologic roles of these cytokines are not clear. We performed an exploratory analysis that included (1) comparisons of plasma interleukin-18 (IL-18) concentrations between patients with AN (n = 21) and healthy controls (n = 39), and (2) correlations between body mass index (BMI) and IL-18 concentrations in both groups, exploring the relationship between malnourishment and IL-18. Plasma IL-18 levels were significantly decreased in patients with AN compared with controls. Plasma IL-18 levels correlated to BMI in controls, but not in patients with AN. These results suggest that a decline in plasma IL-18 levels in patients with AN is not only due to malnourishment, but other pathophysiologic changes as well. IL-18 has a role in the brain’s reaction to sadness and chronic stress. Therefore, decreased levels of IL-18 may commonly occur in patients with chronic AN.

Original languageEnglish
Article number540
JournalNutrients
Volume11
Issue number3
DOIs
Publication statusPublished - 01-03-2019

Fingerprint

interleukin-18
Interleukin-18
anorexia nervosa
Anorexia Nervosa
Malnutrition
malnutrition
body mass index
Body Mass Index
cytokines
Cytokines
brain
Brain

All Science Journal Classification (ASJC) codes

  • Food Science
  • Nutrition and Dietetics

Cite this

Tanaka, Satoshi ; Oya-Ito, Tomoko ; Murakami, Yuki ; Saito, Kuniaki ; Furuta, Sho ; Yu, Yanjie ; Imaeda, Miho ; Kunimoto, Shohko ; Ozaki, Norio. / Decline of plasma concentrations of interleukin-18 in severely malnourished patients with anorexia nervosa : Exploratory analysis. In: Nutrients. 2019 ; Vol. 11, No. 3.
@article{c18d65fa33a5414cb37854c29a43ed3e,
title = "Decline of plasma concentrations of interleukin-18 in severely malnourished patients with anorexia nervosa: Exploratory analysis",
abstract = "Multiple studies on the dynamics of inflammatory cytokines in patients with anorexia nervosa (AN) have been published, although results are not consistent among reports. Thus the pathophysiologic roles of these cytokines are not clear. We performed an exploratory analysis that included (1) comparisons of plasma interleukin-18 (IL-18) concentrations between patients with AN (n = 21) and healthy controls (n = 39), and (2) correlations between body mass index (BMI) and IL-18 concentrations in both groups, exploring the relationship between malnourishment and IL-18. Plasma IL-18 levels were significantly decreased in patients with AN compared with controls. Plasma IL-18 levels correlated to BMI in controls, but not in patients with AN. These results suggest that a decline in plasma IL-18 levels in patients with AN is not only due to malnourishment, but other pathophysiologic changes as well. IL-18 has a role in the brain’s reaction to sadness and chronic stress. Therefore, decreased levels of IL-18 may commonly occur in patients with chronic AN.",
author = "Satoshi Tanaka and Tomoko Oya-Ito and Yuki Murakami and Kuniaki Saito and Sho Furuta and Yanjie Yu and Miho Imaeda and Shohko Kunimoto and Norio Ozaki",
year = "2019",
month = "3",
day = "1",
doi = "10.3390/nu11030540",
language = "English",
volume = "11",
journal = "Nutrients",
issn = "2072-6643",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "3",

}

Tanaka, S, Oya-Ito, T, Murakami, Y, Saito, K, Furuta, S, Yu, Y, Imaeda, M, Kunimoto, S & Ozaki, N 2019, 'Decline of plasma concentrations of interleukin-18 in severely malnourished patients with anorexia nervosa: Exploratory analysis', Nutrients, vol. 11, no. 3, 540. https://doi.org/10.3390/nu11030540

Decline of plasma concentrations of interleukin-18 in severely malnourished patients with anorexia nervosa : Exploratory analysis. / Tanaka, Satoshi; Oya-Ito, Tomoko; Murakami, Yuki; Saito, Kuniaki; Furuta, Sho; Yu, Yanjie; Imaeda, Miho; Kunimoto, Shohko; Ozaki, Norio.

In: Nutrients, Vol. 11, No. 3, 540, 01.03.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Decline of plasma concentrations of interleukin-18 in severely malnourished patients with anorexia nervosa

T2 - Exploratory analysis

AU - Tanaka, Satoshi

AU - Oya-Ito, Tomoko

AU - Murakami, Yuki

AU - Saito, Kuniaki

AU - Furuta, Sho

AU - Yu, Yanjie

AU - Imaeda, Miho

AU - Kunimoto, Shohko

AU - Ozaki, Norio

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Multiple studies on the dynamics of inflammatory cytokines in patients with anorexia nervosa (AN) have been published, although results are not consistent among reports. Thus the pathophysiologic roles of these cytokines are not clear. We performed an exploratory analysis that included (1) comparisons of plasma interleukin-18 (IL-18) concentrations between patients with AN (n = 21) and healthy controls (n = 39), and (2) correlations between body mass index (BMI) and IL-18 concentrations in both groups, exploring the relationship between malnourishment and IL-18. Plasma IL-18 levels were significantly decreased in patients with AN compared with controls. Plasma IL-18 levels correlated to BMI in controls, but not in patients with AN. These results suggest that a decline in plasma IL-18 levels in patients with AN is not only due to malnourishment, but other pathophysiologic changes as well. IL-18 has a role in the brain’s reaction to sadness and chronic stress. Therefore, decreased levels of IL-18 may commonly occur in patients with chronic AN.

AB - Multiple studies on the dynamics of inflammatory cytokines in patients with anorexia nervosa (AN) have been published, although results are not consistent among reports. Thus the pathophysiologic roles of these cytokines are not clear. We performed an exploratory analysis that included (1) comparisons of plasma interleukin-18 (IL-18) concentrations between patients with AN (n = 21) and healthy controls (n = 39), and (2) correlations between body mass index (BMI) and IL-18 concentrations in both groups, exploring the relationship between malnourishment and IL-18. Plasma IL-18 levels were significantly decreased in patients with AN compared with controls. Plasma IL-18 levels correlated to BMI in controls, but not in patients with AN. These results suggest that a decline in plasma IL-18 levels in patients with AN is not only due to malnourishment, but other pathophysiologic changes as well. IL-18 has a role in the brain’s reaction to sadness and chronic stress. Therefore, decreased levels of IL-18 may commonly occur in patients with chronic AN.

UR - http://www.scopus.com/inward/record.url?scp=85062411548&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85062411548&partnerID=8YFLogxK

U2 - 10.3390/nu11030540

DO - 10.3390/nu11030540

M3 - Article

VL - 11

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 3

M1 - 540

ER -