Decrease in PSCA expression caused by Helicobacter pylori infection may promote progression to severe gastritis

Osamu Toyoshima, Chizu Tanikawa, Ryuta Yamamoto, Hidenobu Watanabe, Hiroharu Yamashita, Kosuke Sakitani, Shuntaro Yoshida, Michiaki Kubo, Keitaro Matsuo, Hidemi Ito, Kazuhiko Koike, Yasuyuki Seto, Koichi Matsuda

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

SNP rs2294008 in Prostate Stem Cell Antigen (PSCA) and decreased PSCA expression are associated with gastric cancer. The objective of this study is to investigate the role of rs2294008 and PSCA expression in the gastritis-gastric cancer carcinogenic pathway. We conducted a case-control association study of H. pyloriinfected gastritis and gastric cancer. rs2294008 was associated with the progression to chronic active gastritis (P = 9.4 × 10 -5 ; odds ratio = 3.88, TT + TC vs CC genotype), but not with H. pylori infection per se nor with the progression from active gastritis to gastric cancer. We also assessed the association of rs2294008 with PSCA mRNA expression in the gastric mucosa at various disease stages and found that rs2294008 was associated with PSCA expression (P = 1.3 × 10 -12 ). H. pylori infection (P = 5.1 × 10 -8 ) and eradication therapy (P < 1 × 10 -11 ) resulted in the reduced and increased PSCA expression, respectively, indicating negative regulation of PSCA expression by H. pylori infection. PSCA expression was decreased in severe gastritis compared with mild gastritis only among T allele carriers. Our findings revealed the regulation of PSCA expression by host genetic variation and bacterial infection might contribute to gastritis progression after H. pylori infection.

Original languageEnglish
Pages (from-to)3936-3945
Number of pages10
JournalOncotarget
Volume9
Issue number3
DOIs
Publication statusPublished - 01-01-2018

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Helicobacter Infections
Gastritis
Helicobacter pylori
Prostate
Stem Cells
Antigens
Stomach Neoplasms
Gastric Mucosa
Bacterial Infections
Single Nucleotide Polymorphism
Case-Control Studies
Alleles
Odds Ratio
Genotype
Messenger RNA

All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

Toyoshima, O., Tanikawa, C., Yamamoto, R., Watanabe, H., Yamashita, H., Sakitani, K., ... Matsuda, K. (2018). Decrease in PSCA expression caused by Helicobacter pylori infection may promote progression to severe gastritis. Oncotarget, 9(3), 3936-3945. https://doi.org/10.18632/oncotarget.23278
Toyoshima, Osamu ; Tanikawa, Chizu ; Yamamoto, Ryuta ; Watanabe, Hidenobu ; Yamashita, Hiroharu ; Sakitani, Kosuke ; Yoshida, Shuntaro ; Kubo, Michiaki ; Matsuo, Keitaro ; Ito, Hidemi ; Koike, Kazuhiko ; Seto, Yasuyuki ; Matsuda, Koichi. / Decrease in PSCA expression caused by Helicobacter pylori infection may promote progression to severe gastritis. In: Oncotarget. 2018 ; Vol. 9, No. 3. pp. 3936-3945.
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abstract = "SNP rs2294008 in Prostate Stem Cell Antigen (PSCA) and decreased PSCA expression are associated with gastric cancer. The objective of this study is to investigate the role of rs2294008 and PSCA expression in the gastritis-gastric cancer carcinogenic pathway. We conducted a case-control association study of H. pyloriinfected gastritis and gastric cancer. rs2294008 was associated with the progression to chronic active gastritis (P = 9.4 × 10 -5 ; odds ratio = 3.88, TT + TC vs CC genotype), but not with H. pylori infection per se nor with the progression from active gastritis to gastric cancer. We also assessed the association of rs2294008 with PSCA mRNA expression in the gastric mucosa at various disease stages and found that rs2294008 was associated with PSCA expression (P = 1.3 × 10 -12 ). H. pylori infection (P = 5.1 × 10 -8 ) and eradication therapy (P < 1 × 10 -11 ) resulted in the reduced and increased PSCA expression, respectively, indicating negative regulation of PSCA expression by H. pylori infection. PSCA expression was decreased in severe gastritis compared with mild gastritis only among T allele carriers. Our findings revealed the regulation of PSCA expression by host genetic variation and bacterial infection might contribute to gastritis progression after H. pylori infection.",
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Toyoshima, O, Tanikawa, C, Yamamoto, R, Watanabe, H, Yamashita, H, Sakitani, K, Yoshida, S, Kubo, M, Matsuo, K, Ito, H, Koike, K, Seto, Y & Matsuda, K 2018, 'Decrease in PSCA expression caused by Helicobacter pylori infection may promote progression to severe gastritis', Oncotarget, vol. 9, no. 3, pp. 3936-3945. https://doi.org/10.18632/oncotarget.23278

Decrease in PSCA expression caused by Helicobacter pylori infection may promote progression to severe gastritis. / Toyoshima, Osamu; Tanikawa, Chizu; Yamamoto, Ryuta; Watanabe, Hidenobu; Yamashita, Hiroharu; Sakitani, Kosuke; Yoshida, Shuntaro; Kubo, Michiaki; Matsuo, Keitaro; Ito, Hidemi; Koike, Kazuhiko; Seto, Yasuyuki; Matsuda, Koichi.

In: Oncotarget, Vol. 9, No. 3, 01.01.2018, p. 3936-3945.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Decrease in PSCA expression caused by Helicobacter pylori infection may promote progression to severe gastritis

AU - Toyoshima, Osamu

AU - Tanikawa, Chizu

AU - Yamamoto, Ryuta

AU - Watanabe, Hidenobu

AU - Yamashita, Hiroharu

AU - Sakitani, Kosuke

AU - Yoshida, Shuntaro

AU - Kubo, Michiaki

AU - Matsuo, Keitaro

AU - Ito, Hidemi

AU - Koike, Kazuhiko

AU - Seto, Yasuyuki

AU - Matsuda, Koichi

PY - 2018/1/1

Y1 - 2018/1/1

N2 - SNP rs2294008 in Prostate Stem Cell Antigen (PSCA) and decreased PSCA expression are associated with gastric cancer. The objective of this study is to investigate the role of rs2294008 and PSCA expression in the gastritis-gastric cancer carcinogenic pathway. We conducted a case-control association study of H. pyloriinfected gastritis and gastric cancer. rs2294008 was associated with the progression to chronic active gastritis (P = 9.4 × 10 -5 ; odds ratio = 3.88, TT + TC vs CC genotype), but not with H. pylori infection per se nor with the progression from active gastritis to gastric cancer. We also assessed the association of rs2294008 with PSCA mRNA expression in the gastric mucosa at various disease stages and found that rs2294008 was associated with PSCA expression (P = 1.3 × 10 -12 ). H. pylori infection (P = 5.1 × 10 -8 ) and eradication therapy (P < 1 × 10 -11 ) resulted in the reduced and increased PSCA expression, respectively, indicating negative regulation of PSCA expression by H. pylori infection. PSCA expression was decreased in severe gastritis compared with mild gastritis only among T allele carriers. Our findings revealed the regulation of PSCA expression by host genetic variation and bacterial infection might contribute to gastritis progression after H. pylori infection.

AB - SNP rs2294008 in Prostate Stem Cell Antigen (PSCA) and decreased PSCA expression are associated with gastric cancer. The objective of this study is to investigate the role of rs2294008 and PSCA expression in the gastritis-gastric cancer carcinogenic pathway. We conducted a case-control association study of H. pyloriinfected gastritis and gastric cancer. rs2294008 was associated with the progression to chronic active gastritis (P = 9.4 × 10 -5 ; odds ratio = 3.88, TT + TC vs CC genotype), but not with H. pylori infection per se nor with the progression from active gastritis to gastric cancer. We also assessed the association of rs2294008 with PSCA mRNA expression in the gastric mucosa at various disease stages and found that rs2294008 was associated with PSCA expression (P = 1.3 × 10 -12 ). H. pylori infection (P = 5.1 × 10 -8 ) and eradication therapy (P < 1 × 10 -11 ) resulted in the reduced and increased PSCA expression, respectively, indicating negative regulation of PSCA expression by H. pylori infection. PSCA expression was decreased in severe gastritis compared with mild gastritis only among T allele carriers. Our findings revealed the regulation of PSCA expression by host genetic variation and bacterial infection might contribute to gastritis progression after H. pylori infection.

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Toyoshima O, Tanikawa C, Yamamoto R, Watanabe H, Yamashita H, Sakitani K et al. Decrease in PSCA expression caused by Helicobacter pylori infection may promote progression to severe gastritis. Oncotarget. 2018 Jan 1;9(3):3936-3945. https://doi.org/10.18632/oncotarget.23278