Decrease in PSCA expression caused by Helicobacter pylori infection may promote progression to severe gastritis

Osamu Toyoshima, Chizu Tanikawa, Ryuta Yamamoto, Hidenobu Watanabe, Hiroharu Yamashita, Kosuke Sakitani, Shuntaro Yoshida, Michiaki Kubo, Keitaro Matsuo, Hidemi Ito, Kazuhiko Koike, Yasuyuki Seto, Koichi Matsuda

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6 Citations (Scopus)

Abstract

SNP rs2294008 in Prostate Stem Cell Antigen (PSCA) and decreased PSCA expression are associated with gastric cancer. The objective of this study is to investigate the role of rs2294008 and PSCA expression in the gastritis-gastric cancer carcinogenic pathway. We conducted a case-control association study of H. pyloriinfected gastritis and gastric cancer. rs2294008 was associated with the progression to chronic active gastritis (P = 9.4 × 10-5; odds ratio = 3.88, TT + TC vs CC genotype), but not with H. pylori infection per se nor with the progression from active gastritis to gastric cancer. We also assessed the association of rs2294008 with PSCA mRNA expression in the gastric mucosa at various disease stages and found that rs2294008 was associated with PSCA expression (P = 1.3 × 10-12). H. pylori infection (P = 5.1 × 10-8) and eradication therapy (P < 1 × 10-11) resulted in the reduced and increased PSCA expression, respectively, indicating negative regulation of PSCA expression by H. pylori infection. PSCA expression was decreased in severe gastritis compared with mild gastritis only among T allele carriers. Our findings revealed the regulation of PSCA expression by host genetic variation and bacterial infection might contribute to gastritis progression after H. pylori infection.

Original languageEnglish
Pages (from-to)3936-3945
Number of pages10
JournalOncotarget
Volume9
Issue number3
DOIs
Publication statusPublished - 01-01-2018

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All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

Toyoshima, O., Tanikawa, C., Yamamoto, R., Watanabe, H., Yamashita, H., Sakitani, K., Yoshida, S., Kubo, M., Matsuo, K., Ito, H., Koike, K., Seto, Y., & Matsuda, K. (2018). Decrease in PSCA expression caused by Helicobacter pylori infection may promote progression to severe gastritis. Oncotarget, 9(3), 3936-3945. https://doi.org/10.18632/oncotarget.23278