Decrease in risk of lung cancer death in males after smoking cessation by age at quitting: Findings from the JACC Study

To evaluate the impact of smoking cessation in individuals and populations, we examined the decrease in risk of lung cancer death in male ex-smokers by age at quitting in the Japan Collaborative Cohort Study for Evaluation of Cancer Risk Sponsored by Monbusho (JACC Study), which was initiated from 1988 to 1990 in Japan. For simplicity, subjects were limited to male non-smokers, and former/current smokers who started smoking at ages 18-22, and 33 654 men aged 40-79 years were included. We modeled the mortality rates in non-smokers and current smokers, and compared the rates in ex-smokers with those expected from the model if they had continued smoking. During the mean follow-up of 8.0 years, 341 men died from lung cancer. The mortality rate ration for current smokers, compared to non-smokers, was 5.16, and those for ex-smokers who had quit smoking 0-4, 5-9, 10-14, 15-19 and ≥20 years before were 4.84, 3.19, 2.03, 1.29 and 0.99, respectively. The functions of 3.20×10^-7×(age)^4.5 and 1.96×10^-5×(age-29.6)^4.5 fitted the observed mortality rates (per 100 000 person-years) in non-smokers and continuing smokers, respectively. A greater decrease in lung cancer mortality was estimated among those who quit smoking at younger ages. Stopping smoking earlier in life appears preferable to keep the individual risk low. The absolute rate, however, substantially decreased after smoking cessation even in those who quit at ages 60-69, reflecting the high mortality rate among continuing smokers in the elderly.