Decreased interleukin-6 level in the cerebrospinal fluid of patients with Alzheimer-type dementia

Kiyofumi Yamada, Kazuhiko Kono, Hiroyuki Umegaki, Kazuyoshi Yamada, Akihisa Iguchi, Toshiaki Fukatsu, Nobou Nakashima, Hirotshi Nishiwaki, Yasuhiro Shimada, Yasuko Sugita, Takayuki Yamamoto, Takaaki Hasegawa, Toshitaka Nabeshima

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Abstract

We examined IL-6 levels in the cerebrospinal fluid (CSF) of patients clinically diagnosed with Alzheimer-type dementia (ATD) and with vascular dementia (VD) and of age-matched normal subjects. The IL-6 levels in the CSF of ATD, but not VD patients, were significantly decreased. In the early onset ATD patients (disease onset <65 years), IL-6 levels were reduced to 21% of the control level. The IL-6 levels in the CSF were not associated with the severity of the dementia or the duration of the disease since the identification of the first symptoms.

Original languageEnglish
Pages (from-to)219-221
Number of pages3
JournalNeuroscience Letters
Volume186
Issue number2-3
DOIs
Publication statusPublished - 17-02-1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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    Yamada, K., Kono, K., Umegaki, H., Yamada, K., Iguchi, A., Fukatsu, T., Nakashima, N., Nishiwaki, H., Shimada, Y., Sugita, Y., Yamamoto, T., Hasegawa, T., & Nabeshima, T. (1995). Decreased interleukin-6 level in the cerebrospinal fluid of patients with Alzheimer-type dementia. Neuroscience Letters, 186(2-3), 219-221. https://doi.org/10.1016/0304-3940(95)11318-Q