Decreased interleukin-6 level in the cerebrospinal fluid of patients with Alzheimer-type dementia

Kiyofumi Yamada, Kazuhiko Kono, Hiroyuki Umegaki, Kazuyoshi Yamada, Akihisa Iguchi, Toshiaki Fukatsu, Nobou Nakashima, Hirotshi Nishiwaki, Yasuhiro Shimada, Yasuko Sugita, Takayuki Yamamoto, Takaaki Hasegawa, Toshitaka Nabeshima

Research output: Contribution to journalArticle

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Abstract

We examined IL-6 levels in the cerebrospinal fluid (CSF) of patients clinically diagnosed with Alzheimer-type dementia (ATD) and with vascular dementia (VD) and of age-matched normal subjects. The IL-6 levels in the CSF of ATD, but not VD patients, were significantly decreased. In the early onset ATD patients (disease onset <65 years), IL-6 levels were reduced to 21% of the control level. The IL-6 levels in the CSF were not associated with the severity of the dementia or the duration of the disease since the identification of the first symptoms.

Original languageEnglish
Pages (from-to)219-221
Number of pages3
JournalNeuroscience Letters
Volume186
Issue number2-3
DOIs
Publication statusPublished - 17-02-1995
Externally publishedYes

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Cerebrospinal Fluid
Interleukin-6
Alzheimer Disease
Vascular Dementia
Dementia

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Yamada, Kiyofumi ; Kono, Kazuhiko ; Umegaki, Hiroyuki ; Yamada, Kazuyoshi ; Iguchi, Akihisa ; Fukatsu, Toshiaki ; Nakashima, Nobou ; Nishiwaki, Hirotshi ; Shimada, Yasuhiro ; Sugita, Yasuko ; Yamamoto, Takayuki ; Hasegawa, Takaaki ; Nabeshima, Toshitaka. / Decreased interleukin-6 level in the cerebrospinal fluid of patients with Alzheimer-type dementia. In: Neuroscience Letters. 1995 ; Vol. 186, No. 2-3. pp. 219-221.
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author = "Kiyofumi Yamada and Kazuhiko Kono and Hiroyuki Umegaki and Kazuyoshi Yamada and Akihisa Iguchi and Toshiaki Fukatsu and Nobou Nakashima and Hirotshi Nishiwaki and Yasuhiro Shimada and Yasuko Sugita and Takayuki Yamamoto and Takaaki Hasegawa and Toshitaka Nabeshima",
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Yamada, K, Kono, K, Umegaki, H, Yamada, K, Iguchi, A, Fukatsu, T, Nakashima, N, Nishiwaki, H, Shimada, Y, Sugita, Y, Yamamoto, T, Hasegawa, T & Nabeshima, T 1995, 'Decreased interleukin-6 level in the cerebrospinal fluid of patients with Alzheimer-type dementia', Neuroscience Letters, vol. 186, no. 2-3, pp. 219-221. https://doi.org/10.1016/0304-3940(95)11318-Q

Decreased interleukin-6 level in the cerebrospinal fluid of patients with Alzheimer-type dementia. / Yamada, Kiyofumi; Kono, Kazuhiko; Umegaki, Hiroyuki; Yamada, Kazuyoshi; Iguchi, Akihisa; Fukatsu, Toshiaki; Nakashima, Nobou; Nishiwaki, Hirotshi; Shimada, Yasuhiro; Sugita, Yasuko; Yamamoto, Takayuki; Hasegawa, Takaaki; Nabeshima, Toshitaka.

In: Neuroscience Letters, Vol. 186, No. 2-3, 17.02.1995, p. 219-221.

Research output: Contribution to journalArticle

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T1 - Decreased interleukin-6 level in the cerebrospinal fluid of patients with Alzheimer-type dementia

AU - Yamada, Kiyofumi

AU - Kono, Kazuhiko

AU - Umegaki, Hiroyuki

AU - Yamada, Kazuyoshi

AU - Iguchi, Akihisa

AU - Fukatsu, Toshiaki

AU - Nakashima, Nobou

AU - Nishiwaki, Hirotshi

AU - Shimada, Yasuhiro

AU - Sugita, Yasuko

AU - Yamamoto, Takayuki

AU - Hasegawa, Takaaki

AU - Nabeshima, Toshitaka

PY - 1995/2/17

Y1 - 1995/2/17

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