TY - JOUR
T1 - Decreased interleukin-6 level in the cerebrospinal fluid of patients with Alzheimer-type dementia
AU - Yamada, Kiyofumi
AU - Kono, Kazuhiko
AU - Umegaki, Hiroyuki
AU - Yamada, Kazuyoshi
AU - Iguchi, Akihisa
AU - Fukatsu, Toshiaki
AU - Nakashima, Nobou
AU - Nishiwaki, Hirotshi
AU - Shimada, Yasuhiro
AU - Sugita, Yasuko
AU - Yamamoto, Takayuki
AU - Hasegawa, Takaaki
AU - Nabeshima, Toshitaka
N1 - Funding Information:
for Biomedical Reseæ:ch and Grants from the Japan Research Foundation for Clinical Pharmacology.
Funding Information:
This work was supported in part by a Grant-in-Aid for Gerontological Science Research (91A-2406) from the Ministry of Health and Welfare, Japan, by an SRF Grant
PY - 1995/2/17
Y1 - 1995/2/17
N2 - We examined IL-6 levels in the cerebrospinal fluid (CSF) of patients clinically diagnosed with Alzheimer-type dementia (ATD) and with vascular dementia (VD) and of age-matched normal subjects. The IL-6 levels in the CSF of ATD, but not VD patients, were significantly decreased. In the early onset ATD patients (disease onset <65 years), IL-6 levels were reduced to 21% of the control level. The IL-6 levels in the CSF were not associated with the severity of the dementia or the duration of the disease since the identification of the first symptoms.
AB - We examined IL-6 levels in the cerebrospinal fluid (CSF) of patients clinically diagnosed with Alzheimer-type dementia (ATD) and with vascular dementia (VD) and of age-matched normal subjects. The IL-6 levels in the CSF of ATD, but not VD patients, were significantly decreased. In the early onset ATD patients (disease onset <65 years), IL-6 levels were reduced to 21% of the control level. The IL-6 levels in the CSF were not associated with the severity of the dementia or the duration of the disease since the identification of the first symptoms.
UR - https://www.scopus.com/pages/publications/0028938729
UR - https://www.scopus.com/pages/publications/0028938729#tab=citedBy
U2 - 10.1016/0304-3940(95)11318-Q
DO - 10.1016/0304-3940(95)11318-Q
M3 - Article
C2 - 7777201
AN - SCOPUS:0028938729
SN - 0304-3940
VL - 186
SP - 219
EP - 221
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2-3
ER -