TY - JOUR
T1 - Degradation of Mitochondrial Phospholipids During Experimental Cerebral Ischemia in Rats
AU - Nakahara, Ichiro
AU - Kikuchi, Haruhiko
AU - Taki, Waro
AU - Nishi, Syogo
AU - Kito, Makoto
AU - Yonekawa, Yasuhiro
AU - Goto, Yasunobu
AU - Ogata, Nobuyoshi
PY - 1991/9
Y1 - 1991/9
N2 - Changes in content of brain mitochondrial phospholipids were examined in rats after 30 and 60 min of decapitation ischemia compared with controls, to explore the degradation of the mitochondrial membrane and its relation to dysfunction of mitochondria. Activities of respiratory functions and respiratory enzymes (cytochrome c oxidase; F0F1‐ATPase) decreased significantly during ischemia. Considerable decreases in cardiolipin and phosphatidylinositol content were observed after 60 min, and other phospholipids showed similar but nonsignificant decreases in content. The amount of polyunsaturated fatty acid chains, such as arachidonic and docosahexaenoic acids, was reduced in each phospholipid, in some cases significantly, after 30 and 60 min of ischemia in time‐dependent manners. Degradation of mitochondrial phospholipids during ischemia associated with the deterioration of mitochondrial respiratory functions suggested the significance of such changes in phospholipid content in disintegration of cellular energy metabolism during cerebral ischemia.
AB - Changes in content of brain mitochondrial phospholipids were examined in rats after 30 and 60 min of decapitation ischemia compared with controls, to explore the degradation of the mitochondrial membrane and its relation to dysfunction of mitochondria. Activities of respiratory functions and respiratory enzymes (cytochrome c oxidase; F0F1‐ATPase) decreased significantly during ischemia. Considerable decreases in cardiolipin and phosphatidylinositol content were observed after 60 min, and other phospholipids showed similar but nonsignificant decreases in content. The amount of polyunsaturated fatty acid chains, such as arachidonic and docosahexaenoic acids, was reduced in each phospholipid, in some cases significantly, after 30 and 60 min of ischemia in time‐dependent manners. Degradation of mitochondrial phospholipids during ischemia associated with the deterioration of mitochondrial respiratory functions suggested the significance of such changes in phospholipid content in disintegration of cellular energy metabolism during cerebral ischemia.
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U2 - 10.1111/j.1471-4159.1991.tb08227.x
DO - 10.1111/j.1471-4159.1991.tb08227.x
M3 - Article
C2 - 1650395
AN - SCOPUS:0026353722
SN - 0022-3042
VL - 57
SP - 839
EP - 844
JO - Journal of neurochemistry
JF - Journal of neurochemistry
IS - 3
ER -