Delay in red blood cell recovery after major ABO incompatible bone marrow transplantation

M. Fukuda, K. Matsumoto, S. Kojima, T. Matsuyama, H. Maeda, Y. Akatsuka, S. Tsuzuki, T. Sughara, S. Minami, Y. Kodera

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

In 6 of 27 patients in whom major ABO incompatible marrow was transplanted, the recovery of red blood cells (reticulocyte count greater than or equal to 1%) required more than 50 days after the transplantation. In 3 of them, more than 100 days were required. High titers of pre-transplant anti-A or anti-B agglutinin correlated with the delay in red blood cell recovery (IgM: p less than 0.01, IgG: p less than 0.05). In all of the patients whose pre-transplant IgM titers were 4 or less, and whose IgG titers were 32 or less, the red blood cells recovered within 50 days. Administration of cyclosporine did not correlate with the delay in red blood cell recovery. All the patients finally developed red cell production within 8 months without any treatment.

Original languageEnglish
Pages (from-to)24-28
Number of pages5
Journal[Rinshō ketsueki] The Japanese journal of clinical hematology
Volume32
Issue number1
Publication statusPublished - 01-1991

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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