Demethylation of the RB1 promoter concomitant with reactivation of TET2 and TET3 impairs gastric carcinogenesis in K19-Wnt1/C2mE transgenic mice

Keyphrases

• Aberrant Methylation 25%
• Arenes 25%
• Cell Cycle Regulators 25%
• Cell Viability 25%
• CpG Island 25%
• Curcumin 75%
• Demethylation 100%
• DNA Demethylation 25%
• Gastric Cancer 50%
• Gastric Cancer Surgery 50%
• Gastric Carcinoma 100%
• Gastric Cells 25%
• Gastric Tumor 25%
• Hydrogen Bonds (H-bonds) 50%
• Hypermethylated 25%
• Methylation Status 25%
• Molecular Docking 25%
• Oncogenesis 50%
• Tet Methylcytosine Dioxygenase 2 100%
• TET3 100%
• Therapeutic Strategies 25%
• Transgenic Mice 100%
• Tumor Suppressor Gene 50%
• Wnt1 100%

Biochemistry, Genetics and Molecular Biology

• Carcinogenesis 100%
• Cell Cycle 25%
• Cell Viability 25%
• CpG Island 25%
• Demethylation 100%
• DNA Demethylation 25%
• Docking (Molecular) 25%
• Enzyme 25%
• Hydrogen Bond 25%
• Methylation 50%
• Promoter Region 100%
• Transgenic Mouse 100%
• Tumor Suppressor Gene 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Carcinogenesis 100%
• Cell Viability 33%
• Curcumin 100%
• Hydrogen Bond 33%
• Malignant Neoplasm 33%
• Polycyclic Aromatic Hydrocarbon 33%
• Stomach Cancer 100%
• Stomach Tumor 33%
• Transgenic Mouse 100%
• Tumor Suppressor Protein 66%