Demographic and lifestyle factors and survival among patients with esophageal and gastric cancer: The Biobank Japan Project

BioBank Japan Cooperative Hospital Group

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: Several studies have evaluated associations between the characteristics of patients with esophageal and gastric cancer and survival, but these associations remain unclear. We described the distribution of demographic and lifestyle factors among patients with esophageal and gastric cancer in Japan, and investigated their potential effects on survival. Methods: Between 2003 and 2007, 24- to 95-year-old Japanese patients with esophageal and gastric cancer were enrolled in the BioBank Japan Project. The analysis included 365 patients with esophageal squamous cell carcinoma (ESCC) and 1574 patients with gastric cancer. Hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality were estimated using medical institution-stratified Cox proportional hazards models. Results: During follow-up, 213 patients with ESCC (median follow-up, 4.4 years) and 603 patients with gastric cancer (median follow-up, 6.1 years) died. Among patients with ESCC, the mortality risk was higher in ever drinkers versus never drinkers (multivariable HR = 2.37, 95% CI: 1.24, 4.53). Among patients with gastric cancer, the mortality risk was higher in underweight patients versus patients of normal weight (multivariable HR = 1.66, 95% CI: 1.34, 2.05). Compared to patients with gastric cancer with no physical exercise habit, those who exercised ≥ 3 times/week had a lower mortality risk (multivariate HR = 0.75, 95% CI = 0.61, 0.93). However, lack of stage in many cases was a limitation. Conclusions: Among patients with ESCC, alcohol drinkers have a poor prognosis. Patients with gastric cancer who are underweight also have a poor prognosis, whereas patients with physical exercise habits have a good prognosis.

Original languageEnglish
Pages (from-to)S29-S35
JournalJournal of epidemiology
Volume27
Issue number3
DOIs
Publication statusPublished - 01-01-2017

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Esophageal Neoplasms
Stomach Neoplasms
Life Style
Japan
Demography
Survival
Confidence Intervals
Mortality
Thinness
Habits
Exercise
Proportional Hazards Models

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

@article{7fed766a072f427a94add0b988060b38,
title = "Demographic and lifestyle factors and survival among patients with esophageal and gastric cancer: The Biobank Japan Project",
abstract = "Background: Several studies have evaluated associations between the characteristics of patients with esophageal and gastric cancer and survival, but these associations remain unclear. We described the distribution of demographic and lifestyle factors among patients with esophageal and gastric cancer in Japan, and investigated their potential effects on survival. Methods: Between 2003 and 2007, 24- to 95-year-old Japanese patients with esophageal and gastric cancer were enrolled in the BioBank Japan Project. The analysis included 365 patients with esophageal squamous cell carcinoma (ESCC) and 1574 patients with gastric cancer. Hazard ratios (HRs) and 95{\%} confidence intervals (CIs) for mortality were estimated using medical institution-stratified Cox proportional hazards models. Results: During follow-up, 213 patients with ESCC (median follow-up, 4.4 years) and 603 patients with gastric cancer (median follow-up, 6.1 years) died. Among patients with ESCC, the mortality risk was higher in ever drinkers versus never drinkers (multivariable HR = 2.37, 95{\%} CI: 1.24, 4.53). Among patients with gastric cancer, the mortality risk was higher in underweight patients versus patients of normal weight (multivariable HR = 1.66, 95{\%} CI: 1.34, 2.05). Compared to patients with gastric cancer with no physical exercise habit, those who exercised ≥ 3 times/week had a lower mortality risk (multivariate HR = 0.75, 95{\%} CI = 0.61, 0.93). However, lack of stage in many cases was a limitation. Conclusions: Among patients with ESCC, alcohol drinkers have a poor prognosis. Patients with gastric cancer who are underweight also have a poor prognosis, whereas patients with physical exercise habits have a good prognosis.",
author = "{BioBank Japan Cooperative Hospital Group} and Emiko Okada and Shigekazu Ukawa and Koshi Nakamura and Makoto Hirata and Akiko Nagai and Koichi Matsuda and Toshiharu Ninomiya and Yutaka Kiyohara and Kaori Muto and Yoichiro Kamatani and Zentaro Yamagata and Michiaki Kubo and Yusuke Nakamura and Akiko Tamakoshi and Rai Shimoyama and Shinichiro Makimoto and Hiromasa Harada and Tomoaki Fujikawa and Michiaki Kubo and Eiji Uchida and Masao Miyashita and Yoshiaki Kajiyama and Natsumi Tomita and Akihito Nagahara and Satoshi Asai and Mitsuhiko Moriyama and Yasuo Takahashi and Tomoaki Fujioka and Wataru Obara and Seijiro Mori and Hideki Ito and Satoshi Nagayama and Yoshio Miki and Akihide Masumoto and Akira Yamada and Yasuko Nishizawa and Ken Kodama and Hiromitsu Ban and Satoshi Murata and Yukihiro Koretsune and Motohiro Hirao and Hideo Ogata",
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language = "English",
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Demographic and lifestyle factors and survival among patients with esophageal and gastric cancer : The Biobank Japan Project. / BioBank Japan Cooperative Hospital Group.

In: Journal of epidemiology, Vol. 27, No. 3, 01.01.2017, p. S29-S35.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Demographic and lifestyle factors and survival among patients with esophageal and gastric cancer

T2 - The Biobank Japan Project

AU - BioBank Japan Cooperative Hospital Group

AU - Okada, Emiko

AU - Ukawa, Shigekazu

AU - Nakamura, Koshi

AU - Hirata, Makoto

AU - Nagai, Akiko

AU - Matsuda, Koichi

AU - Ninomiya, Toshiharu

AU - Kiyohara, Yutaka

AU - Muto, Kaori

AU - Kamatani, Yoichiro

AU - Yamagata, Zentaro

AU - Kubo, Michiaki

AU - Nakamura, Yusuke

AU - Tamakoshi, Akiko

AU - Shimoyama, Rai

AU - Makimoto, Shinichiro

AU - Harada, Hiromasa

AU - Fujikawa, Tomoaki

AU - Kubo, Michiaki

AU - Uchida, Eiji

AU - Miyashita, Masao

AU - Kajiyama, Yoshiaki

AU - Tomita, Natsumi

AU - Nagahara, Akihito

AU - Asai, Satoshi

AU - Moriyama, Mitsuhiko

AU - Takahashi, Yasuo

AU - Fujioka, Tomoaki

AU - Obara, Wataru

AU - Mori, Seijiro

AU - Ito, Hideki

AU - Nagayama, Satoshi

AU - Miki, Yoshio

AU - Masumoto, Akihide

AU - Yamada, Akira

AU - Nishizawa, Yasuko

AU - Kodama, Ken

AU - Ban, Hiromitsu

AU - Murata, Satoshi

AU - Koretsune, Yukihiro

AU - Hirao, Motohiro

AU - Ogata, Hideo

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Background: Several studies have evaluated associations between the characteristics of patients with esophageal and gastric cancer and survival, but these associations remain unclear. We described the distribution of demographic and lifestyle factors among patients with esophageal and gastric cancer in Japan, and investigated their potential effects on survival. Methods: Between 2003 and 2007, 24- to 95-year-old Japanese patients with esophageal and gastric cancer were enrolled in the BioBank Japan Project. The analysis included 365 patients with esophageal squamous cell carcinoma (ESCC) and 1574 patients with gastric cancer. Hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality were estimated using medical institution-stratified Cox proportional hazards models. Results: During follow-up, 213 patients with ESCC (median follow-up, 4.4 years) and 603 patients with gastric cancer (median follow-up, 6.1 years) died. Among patients with ESCC, the mortality risk was higher in ever drinkers versus never drinkers (multivariable HR = 2.37, 95% CI: 1.24, 4.53). Among patients with gastric cancer, the mortality risk was higher in underweight patients versus patients of normal weight (multivariable HR = 1.66, 95% CI: 1.34, 2.05). Compared to patients with gastric cancer with no physical exercise habit, those who exercised ≥ 3 times/week had a lower mortality risk (multivariate HR = 0.75, 95% CI = 0.61, 0.93). However, lack of stage in many cases was a limitation. Conclusions: Among patients with ESCC, alcohol drinkers have a poor prognosis. Patients with gastric cancer who are underweight also have a poor prognosis, whereas patients with physical exercise habits have a good prognosis.

AB - Background: Several studies have evaluated associations between the characteristics of patients with esophageal and gastric cancer and survival, but these associations remain unclear. We described the distribution of demographic and lifestyle factors among patients with esophageal and gastric cancer in Japan, and investigated their potential effects on survival. Methods: Between 2003 and 2007, 24- to 95-year-old Japanese patients with esophageal and gastric cancer were enrolled in the BioBank Japan Project. The analysis included 365 patients with esophageal squamous cell carcinoma (ESCC) and 1574 patients with gastric cancer. Hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality were estimated using medical institution-stratified Cox proportional hazards models. Results: During follow-up, 213 patients with ESCC (median follow-up, 4.4 years) and 603 patients with gastric cancer (median follow-up, 6.1 years) died. Among patients with ESCC, the mortality risk was higher in ever drinkers versus never drinkers (multivariable HR = 2.37, 95% CI: 1.24, 4.53). Among patients with gastric cancer, the mortality risk was higher in underweight patients versus patients of normal weight (multivariable HR = 1.66, 95% CI: 1.34, 2.05). Compared to patients with gastric cancer with no physical exercise habit, those who exercised ≥ 3 times/week had a lower mortality risk (multivariate HR = 0.75, 95% CI = 0.61, 0.93). However, lack of stage in many cases was a limitation. Conclusions: Among patients with ESCC, alcohol drinkers have a poor prognosis. Patients with gastric cancer who are underweight also have a poor prognosis, whereas patients with physical exercise habits have a good prognosis.

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U2 - 10.1016/j.je.2016.12.002

DO - 10.1016/j.je.2016.12.002

M3 - Article

C2 - 28190659

AN - SCOPUS:85016408779

VL - 27

SP - S29-S35

JO - Journal of Epidemiology

JF - Journal of Epidemiology

SN - 0917-5040

IS - 3

ER -