Demographics and Outcomes of Patients with Pediatric Febrile Convulsive Status Epilepticus

Masahiro Nishiyama, Hiroaki Nagase, Tsukasa Tanaka, Kyoko Fujita, Azusa Maruyama, Daisaku Toyoshima, Taku Nakagawa, Mariko Ikeda, Ichiro Morioka, Naoya Morisada, Satoshi Takada, Kazumoto Iijima

Research output: Contribution to journalArticle

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Abstract

Background Convulsive status epilepticus with fever is common and may be related to neurological sequela in children. However, there are limited data on the demographics and risk factors of this phenomenon. Thus, we aimed to describe the demographics and risk factors of neurological sequela among children with convulsive status epilepticus with fever. Methods We reviewed convulsive status epilepticus with fever cases in the pediatric intensive care unit at Kobe Children's Hospital between 2002 and 2013. We included patients with intrinsic neurological disease, and excluded those with obvious central nervous system infection. Cases of neurological worsening were categorized as poor outcome using the pediatric cerebral performance category scale. Possible risk factors for poor outcome included age, sex, neurological medical history, seizure duration, body temperature, and level of consciousness. Results A total of 253 patients (128 males), aged 1 month to 15 years (mean 45 ± 40 months), were enrolled. Three patients (1.2%) died during hospitalization, and 32 (12.6%) patients had a poor outcome. A univariate analysis identified male sex, absence of epilepsy history, body temperature above 40°C on admission, seizure duration longer than 120 minutes, impaired consciousness at 12 hours after onset, and presence of nonconvulsive seizure as potential predictors of poor outcome. A multivariate analysis, revealed that an absence of epilepsy history (odds ratio = 11.18), body temperature above 40°C on admission (odds ratio = 3.39), or impaired consciousness at 12 hours after onset (odds ratio = 41.85) was associated with poor outcome. Conclusions Our study indicated that absence of epilepsy history, high temperature, and/or prolonged impaired consciousness were associated with brain injury.

Original languageEnglish
Pages (from-to)499-503
Number of pages5
JournalPediatric Neurology
Volume52
Issue number5
DOIs
Publication statusPublished - 01-05-2015

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Status Epilepticus
Consciousness
Absence Epilepsy
Fever
Body Temperature
Demography
Pediatrics
Seizures
Odds Ratio
Central Nervous System Infections
Pediatric Intensive Care Units
Brain Injuries
Hospitalization
Multivariate Analysis
Temperature

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology

Cite this

Nishiyama, M., Nagase, H., Tanaka, T., Fujita, K., Maruyama, A., Toyoshima, D., ... Iijima, K. (2015). Demographics and Outcomes of Patients with Pediatric Febrile Convulsive Status Epilepticus. Pediatric Neurology, 52(5), 499-503. https://doi.org/10.1016/j.pediatrneurol.2015.02.001
Nishiyama, Masahiro ; Nagase, Hiroaki ; Tanaka, Tsukasa ; Fujita, Kyoko ; Maruyama, Azusa ; Toyoshima, Daisaku ; Nakagawa, Taku ; Ikeda, Mariko ; Morioka, Ichiro ; Morisada, Naoya ; Takada, Satoshi ; Iijima, Kazumoto. / Demographics and Outcomes of Patients with Pediatric Febrile Convulsive Status Epilepticus. In: Pediatric Neurology. 2015 ; Vol. 52, No. 5. pp. 499-503.
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Nishiyama, M, Nagase, H, Tanaka, T, Fujita, K, Maruyama, A, Toyoshima, D, Nakagawa, T, Ikeda, M, Morioka, I, Morisada, N, Takada, S & Iijima, K 2015, 'Demographics and Outcomes of Patients with Pediatric Febrile Convulsive Status Epilepticus', Pediatric Neurology, vol. 52, no. 5, pp. 499-503. https://doi.org/10.1016/j.pediatrneurol.2015.02.001

Demographics and Outcomes of Patients with Pediatric Febrile Convulsive Status Epilepticus. / Nishiyama, Masahiro; Nagase, Hiroaki; Tanaka, Tsukasa; Fujita, Kyoko; Maruyama, Azusa; Toyoshima, Daisaku; Nakagawa, Taku; Ikeda, Mariko; Morioka, Ichiro; Morisada, Naoya; Takada, Satoshi; Iijima, Kazumoto.

In: Pediatric Neurology, Vol. 52, No. 5, 01.05.2015, p. 499-503.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Demographics and Outcomes of Patients with Pediatric Febrile Convulsive Status Epilepticus

AU - Nishiyama, Masahiro

AU - Nagase, Hiroaki

AU - Tanaka, Tsukasa

AU - Fujita, Kyoko

AU - Maruyama, Azusa

AU - Toyoshima, Daisaku

AU - Nakagawa, Taku

AU - Ikeda, Mariko

AU - Morioka, Ichiro

AU - Morisada, Naoya

AU - Takada, Satoshi

AU - Iijima, Kazumoto

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Background Convulsive status epilepticus with fever is common and may be related to neurological sequela in children. However, there are limited data on the demographics and risk factors of this phenomenon. Thus, we aimed to describe the demographics and risk factors of neurological sequela among children with convulsive status epilepticus with fever. Methods We reviewed convulsive status epilepticus with fever cases in the pediatric intensive care unit at Kobe Children's Hospital between 2002 and 2013. We included patients with intrinsic neurological disease, and excluded those with obvious central nervous system infection. Cases of neurological worsening were categorized as poor outcome using the pediatric cerebral performance category scale. Possible risk factors for poor outcome included age, sex, neurological medical history, seizure duration, body temperature, and level of consciousness. Results A total of 253 patients (128 males), aged 1 month to 15 years (mean 45 ± 40 months), were enrolled. Three patients (1.2%) died during hospitalization, and 32 (12.6%) patients had a poor outcome. A univariate analysis identified male sex, absence of epilepsy history, body temperature above 40°C on admission, seizure duration longer than 120 minutes, impaired consciousness at 12 hours after onset, and presence of nonconvulsive seizure as potential predictors of poor outcome. A multivariate analysis, revealed that an absence of epilepsy history (odds ratio = 11.18), body temperature above 40°C on admission (odds ratio = 3.39), or impaired consciousness at 12 hours after onset (odds ratio = 41.85) was associated with poor outcome. Conclusions Our study indicated that absence of epilepsy history, high temperature, and/or prolonged impaired consciousness were associated with brain injury.

AB - Background Convulsive status epilepticus with fever is common and may be related to neurological sequela in children. However, there are limited data on the demographics and risk factors of this phenomenon. Thus, we aimed to describe the demographics and risk factors of neurological sequela among children with convulsive status epilepticus with fever. Methods We reviewed convulsive status epilepticus with fever cases in the pediatric intensive care unit at Kobe Children's Hospital between 2002 and 2013. We included patients with intrinsic neurological disease, and excluded those with obvious central nervous system infection. Cases of neurological worsening were categorized as poor outcome using the pediatric cerebral performance category scale. Possible risk factors for poor outcome included age, sex, neurological medical history, seizure duration, body temperature, and level of consciousness. Results A total of 253 patients (128 males), aged 1 month to 15 years (mean 45 ± 40 months), were enrolled. Three patients (1.2%) died during hospitalization, and 32 (12.6%) patients had a poor outcome. A univariate analysis identified male sex, absence of epilepsy history, body temperature above 40°C on admission, seizure duration longer than 120 minutes, impaired consciousness at 12 hours after onset, and presence of nonconvulsive seizure as potential predictors of poor outcome. A multivariate analysis, revealed that an absence of epilepsy history (odds ratio = 11.18), body temperature above 40°C on admission (odds ratio = 3.39), or impaired consciousness at 12 hours after onset (odds ratio = 41.85) was associated with poor outcome. Conclusions Our study indicated that absence of epilepsy history, high temperature, and/or prolonged impaired consciousness were associated with brain injury.

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