Demonstration of type II latency in T lymphocytes of Epstein-Barr Virus-associated hemophagocytic lymphohistiocytosis

Yoshinori Ito, Yoshiki Kawamura, Seiko Iwata, Jun ichi Kawada, Tetsushi Yoshikawa, Hiroshi Kimura

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Epstein-Barr virus (EBV) is the most common infectious cause of non-genetic hemophagocytic lymphohistiocytosis (HLH). To investigate EBV-infected lymphocytes and immune dysfunction in EBV-associated HLH, blood samples from a 6-year-old boy were longitudinally analyzed using molecular techniques. EBV-positive lymphocytes were detected as CD5+, CD8+, and/or HLA DR+ lymphocytes on Day 25 of the disease, mostly disappearing thereafter. CD8+ cells specific for lytic antigen BRLF1 were detected, but cells specific for latent antigens EBNA3 and LMP2 were not. EBV genes EBNA1, LMP1, LMP2, EBER1, BARTs were detected, suggesting a latency type II gene expression pattern in this case.

Original languageEnglish
Pages (from-to)326-328
Number of pages3
JournalPediatric Blood and Cancer
Volume60
Issue number2
DOIs
Publication statusPublished - 01-02-2013

Fingerprint

Hemophagocytic Lymphohistiocytosis
Human Herpesvirus 4
T-Lymphocytes
Lymphocytes
Antigens
HLA-DR Antigens
Gene Expression
Genes

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this

Ito, Yoshinori ; Kawamura, Yoshiki ; Iwata, Seiko ; Kawada, Jun ichi ; Yoshikawa, Tetsushi ; Kimura, Hiroshi. / Demonstration of type II latency in T lymphocytes of Epstein-Barr Virus-associated hemophagocytic lymphohistiocytosis. In: Pediatric Blood and Cancer. 2013 ; Vol. 60, No. 2. pp. 326-328.
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Demonstration of type II latency in T lymphocytes of Epstein-Barr Virus-associated hemophagocytic lymphohistiocytosis. / Ito, Yoshinori; Kawamura, Yoshiki; Iwata, Seiko; Kawada, Jun ichi; Yoshikawa, Tetsushi; Kimura, Hiroshi.

In: Pediatric Blood and Cancer, Vol. 60, No. 2, 01.02.2013, p. 326-328.

Research output: Contribution to journalArticle

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