TY - JOUR
T1 - Demonstration of type II latency in T lymphocytes of Epstein-Barr Virus-associated hemophagocytic lymphohistiocytosis
AU - Ito, Yoshinori
AU - Kawamura, Yoshiki
AU - Iwata, Seiko
AU - Kawada, Jun ichi
AU - Yoshikawa, Tetsushi
AU - Kimura, Hiroshi
PY - 2013/2
Y1 - 2013/2
N2 - Epstein-Barr virus (EBV) is the most common infectious cause of non-genetic hemophagocytic lymphohistiocytosis (HLH). To investigate EBV-infected lymphocytes and immune dysfunction in EBV-associated HLH, blood samples from a 6-year-old boy were longitudinally analyzed using molecular techniques. EBV-positive lymphocytes were detected as CD5+, CD8+, and/or HLA DR+ lymphocytes on Day 25 of the disease, mostly disappearing thereafter. CD8+ cells specific for lytic antigen BRLF1 were detected, but cells specific for latent antigens EBNA3 and LMP2 were not. EBV genes EBNA1, LMP1, LMP2, EBER1, BARTs were detected, suggesting a latency type II gene expression pattern in this case.
AB - Epstein-Barr virus (EBV) is the most common infectious cause of non-genetic hemophagocytic lymphohistiocytosis (HLH). To investigate EBV-infected lymphocytes and immune dysfunction in EBV-associated HLH, blood samples from a 6-year-old boy were longitudinally analyzed using molecular techniques. EBV-positive lymphocytes were detected as CD5+, CD8+, and/or HLA DR+ lymphocytes on Day 25 of the disease, mostly disappearing thereafter. CD8+ cells specific for lytic antigen BRLF1 were detected, but cells specific for latent antigens EBNA3 and LMP2 were not. EBV genes EBNA1, LMP1, LMP2, EBER1, BARTs were detected, suggesting a latency type II gene expression pattern in this case.
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U2 - 10.1002/pbc.24319
DO - 10.1002/pbc.24319
M3 - Article
C2 - 22961815
AN - SCOPUS:84871109356
SN - 1545-5009
VL - 60
SP - 326
EP - 328
JO - Pediatric Blood and Cancer
JF - Pediatric Blood and Cancer
IS - 2
ER -