Denervation of dopaminergic neurons with 6-hydroxydopamine increases nerve growth factor content in rat brain

Atsumi Nitta, Yoshiko Furukawa, Kyozo Hayashi, Masayuki Hiramatsu, Tsutomu Kameyama, Takaaki Hasegawa, Toshitaka Nabeshima

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Denervation of dopaminergic neurons by intra nigral injection of 6-hydroxydopamine (6-OHDA) increased nerve growth factor (NGF) content in the cortex and hippocampus, both of which are innervated by cholinergic neurons. The increase continued during an observation period of 0.5-28 days after the lesion. The time course of changes in NGF content was quite different from that of cholinergic neuron denervation. The decreased dopamine content produced in the striatum by 6-OHDA injection was not recovered during the observation period. These results suggest that dopaminergic neuron damage may affect NGF synthesis.

Original languageEnglish
Pages (from-to)152-156
Number of pages5
JournalNeuroscience Letters
Issue number1-2
Publication statusPublished - 14-09-1992
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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