Denervation of dopaminergic neurons with 6-hydroxydopamine increases nerve growth factor content in rat brain

Atsumi Nitta, Yoshiko Furukawa, Kyozo Hayashi, Masayuki Hiramatsu, Tsutomu Kameyama, Takaaki Hasegawa, Toshitaka Nabeshima

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Denervation of dopaminergic neurons by intra nigral injection of 6-hydroxydopamine (6-OHDA) increased nerve growth factor (NGF) content in the cortex and hippocampus, both of which are innervated by cholinergic neurons. The increase continued during an observation period of 0.5-28 days after the lesion. The time course of changes in NGF content was quite different from that of cholinergic neuron denervation. The decreased dopamine content produced in the striatum by 6-OHDA injection was not recovered during the observation period. These results suggest that dopaminergic neuron damage may affect NGF synthesis.

Original languageEnglish
Pages (from-to)152-156
Number of pages5
JournalNeuroscience Letters
Volume144
Issue number1-2
DOIs
Publication statusPublished - 14-09-1992

Fingerprint

Oxidopamine
Dopaminergic Neurons
Nerve Growth Factor
Denervation
Cholinergic Neurons
Brain
Observation
Injections
Substantia Nigra
Hippocampus
Dopamine

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Nitta, Atsumi ; Furukawa, Yoshiko ; Hayashi, Kyozo ; Hiramatsu, Masayuki ; Kameyama, Tsutomu ; Hasegawa, Takaaki ; Nabeshima, Toshitaka. / Denervation of dopaminergic neurons with 6-hydroxydopamine increases nerve growth factor content in rat brain. In: Neuroscience Letters. 1992 ; Vol. 144, No. 1-2. pp. 152-156.
@article{2f17803f202745ccad0106f651bab52c,
title = "Denervation of dopaminergic neurons with 6-hydroxydopamine increases nerve growth factor content in rat brain",
abstract = "Denervation of dopaminergic neurons by intra nigral injection of 6-hydroxydopamine (6-OHDA) increased nerve growth factor (NGF) content in the cortex and hippocampus, both of which are innervated by cholinergic neurons. The increase continued during an observation period of 0.5-28 days after the lesion. The time course of changes in NGF content was quite different from that of cholinergic neuron denervation. The decreased dopamine content produced in the striatum by 6-OHDA injection was not recovered during the observation period. These results suggest that dopaminergic neuron damage may affect NGF synthesis.",
author = "Atsumi Nitta and Yoshiko Furukawa and Kyozo Hayashi and Masayuki Hiramatsu and Tsutomu Kameyama and Takaaki Hasegawa and Toshitaka Nabeshima",
year = "1992",
month = "9",
day = "14",
doi = "10.1016/0304-3940(92)90738-S",
language = "English",
volume = "144",
pages = "152--156",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1-2",

}

Denervation of dopaminergic neurons with 6-hydroxydopamine increases nerve growth factor content in rat brain. / Nitta, Atsumi; Furukawa, Yoshiko; Hayashi, Kyozo; Hiramatsu, Masayuki; Kameyama, Tsutomu; Hasegawa, Takaaki; Nabeshima, Toshitaka.

In: Neuroscience Letters, Vol. 144, No. 1-2, 14.09.1992, p. 152-156.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Denervation of dopaminergic neurons with 6-hydroxydopamine increases nerve growth factor content in rat brain

AU - Nitta, Atsumi

AU - Furukawa, Yoshiko

AU - Hayashi, Kyozo

AU - Hiramatsu, Masayuki

AU - Kameyama, Tsutomu

AU - Hasegawa, Takaaki

AU - Nabeshima, Toshitaka

PY - 1992/9/14

Y1 - 1992/9/14

N2 - Denervation of dopaminergic neurons by intra nigral injection of 6-hydroxydopamine (6-OHDA) increased nerve growth factor (NGF) content in the cortex and hippocampus, both of which are innervated by cholinergic neurons. The increase continued during an observation period of 0.5-28 days after the lesion. The time course of changes in NGF content was quite different from that of cholinergic neuron denervation. The decreased dopamine content produced in the striatum by 6-OHDA injection was not recovered during the observation period. These results suggest that dopaminergic neuron damage may affect NGF synthesis.

AB - Denervation of dopaminergic neurons by intra nigral injection of 6-hydroxydopamine (6-OHDA) increased nerve growth factor (NGF) content in the cortex and hippocampus, both of which are innervated by cholinergic neurons. The increase continued during an observation period of 0.5-28 days after the lesion. The time course of changes in NGF content was quite different from that of cholinergic neuron denervation. The decreased dopamine content produced in the striatum by 6-OHDA injection was not recovered during the observation period. These results suggest that dopaminergic neuron damage may affect NGF synthesis.

UR - http://www.scopus.com/inward/record.url?scp=0026666242&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026666242&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(92)90738-S

DO - 10.1016/0304-3940(92)90738-S

M3 - Article

C2 - 1436695

AN - SCOPUS:0026666242

VL - 144

SP - 152

EP - 156

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1-2

ER -